{
  "id": 16390,
  "label": "classic paraneoplastic limbic encephalitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015590",
  "properties": {
    "xrefs": [
      "GARD:0025066",
      "Orphanet:163898"
    ],
    "synonyms": [
      "classic paraneoplastic limbic encephalitis, with or without intracellular antigens"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Classic paraneoplastic limbic encephalitis is a rare neuroimmunological disorder characterized by the sudden onset of seizures, progressive memory impairment (which may develop into dementia) and psychiatric manifestations (e.g. depression, personality changes, loss of social inhibition) associated with cancer (most commonly small-cell carcinoma of the lung) in the absence of tumor cell invasion of the nervous system. Other reported features include ataxia, dystonia, paresthesia, tremors, paranoid ideation, and hallucinations. The presence of antibodies that act on neuronal antigens (such as anti-Hu, anti-Ma2, anti-amphiphysin) are typically observed."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16389,
      "label": "paraneoplastic limbic encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16388,
        18348
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025065",
          "ICD9:323.81",
          "NCIT:C4350",
          "Orphanet:163895",
          "SCTID:445014002",
          "icd11.foundation:1147819644"
        ],
        "synonyms": [
          "limbic encephalitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare disorder characterized by degenerative changes in the limbic area of the brain. Causes include infections and autoimmune conditions; it may also manifest as a paraneoplastic syndrome, most often caused by small cell lung carcinoma. Signs and symptoms include behavioral changes, hallucinations and dementia."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015589"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16389,
      "label": "paraneoplastic limbic encephalitis"
    }
  ]
}