{
  "id": 16404,
  "label": "acquired aplastic anemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015610",
  "properties": {
    "xrefs": [
      "GARD:0020058",
      "MEDGEN:543648",
      "NANDO:2201277",
      "Orphanet:164823",
      "SCTID:55907008",
      "UMLS:C0271907"
    ],
    "synonyms": [
      "acquired aplastic anemia",
      "rare acquired aplastic anaemia",
      "rare acquired aplastic anemia"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An instance of aplastic anemia that is acquired during the lifetime of the individual."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 16610,
      "label": "aplastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4394
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12449",
          "GARD:0020234",
          "ICD9:284.8",
          "ICD9:284.9",
          "MEDGEN:8063",
          "MESH:D000741",
          "NANDO:1200295",
          "NANDO:1200301",
          "NANDO:2100201",
          "NANDO:2200693",
          "NCIT:C2870",
          "OMIM:609135",
          "Orphanet:182040",
          "SCTID:306058006",
          "UMLS:C0002874"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015909"
    }
  ],
  "children": [
    {
      "id": 10906,
      "label": "primary myelofibrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16404,
        19727
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4971",
          "EFO:0002430",
          "GARD:0008618",
          "ICD10CM:D47.4",
          "ICD9:238.76",
          "ICD9:289.83",
          "ICDO:9961/3",
          "MEDGEN:7929",
          "MESH:D055728",
          "NCIT:C2862",
          "NORD:1611",
          "OMIM:254450",
          "ONCOTREE:PMF",
          "Orphanet:824",
          "UMLS:C0001815",
          "icd11.foundation:1407285327",
          "icd11.foundation:336704235"
        ],
        "synonyms": [
          "AMM",
          "Agnogenic myeloid metaplasia",
          "CIMF",
          "chronic idiopathic myelofibrosis",
          "idiopathic bone marrow fibrosis",
          "idiopathic myelofibrosis",
          "myelofibrosis with myeloid metaplasia, somatic",
          "myelofibrosis, somatic",
          "myelosclerosis with myeloid metaplasia",
          "osteomyelofibrosis",
          "primary myelofibrosis",
          "myelofibrosis with myeloid metaplasia",
          "myelofibrosis",
          "myeloid metaplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Myelofibrosis with myeloid metaplasia is a myeloproliferative disease with annual incidence of approximately 1 case per 100,000 individuals and age at diagnosis around 60 (an increased prevalence is noted in Ashkenazi Jews). Clinical manifestations depend on the type of blood cell affected and may include anemia, pallor, splenomegaly, hypermetabolic state, petechiae, ecchymosis, bleeding, lymphadenopathy, hepatomegaly, portal hypertension."
      },
      "child_count": 8,
      "reference_id": "MONDO:0009692"
    },
    {
      "id": 19739,
      "label": "primary acquired red cell aplasia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16404
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019465",
          "MedDRA:10038184",
          "Orphanet:98421"
        ],
        "synonyms": [
          "red cell aplasia",
          "primary autoimmune red cell aplasia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0020113"
    },
    {
      "id": 23983,
      "label": "paroxysmal nocturnal hemoglobinuria",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5544,
        5550,
        7996,
        16404,
        21353
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060284",
          "GARD:0007337",
          "HGNC:8957",
          "HP:0004818",
          "ICD10CM:D59.5",
          "MEDGEN:7471",
          "MedDRA:10034042",
          "NCIT:C61233",
          "NORD:1557",
          "OMIMPS:300818",
          "Orphanet:447",
          "SCTID:1963002",
          "UMLS:C0024790",
          "icd11.foundation:859588467"
        ],
        "synonyms": [
          "Marchiafava-Micheli disease",
          "PNH",
          "acquired paroxysmal nocturnal hemoglobinuria",
          "hereditary paroxysmal nocturnal hemoglobinuria",
          "inherited paroxysmal nocturnal hemoglobinuria",
          "paroxysmal hemoglobinuria"
        ],
        "categories": [
          {
            "ref": "MONDO:0002118",
            "name": "urinary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Paroxysmal nocturnal hemoglobinuria (PNH) is an acquired clonal hematopoietic stem cell disorder characterized by corpuscular hemolytic anemia, bone marrow failure and frequent thrombotic events."
      },
      "child_count": 10,
      "reference_id": "MONDO:0100244"
    }
  ],
  "roots": [
    {
      "id": 16610,
      "label": "aplastic anemia"
    }
  ]
}