{
  "id": 16438,
  "label": "sporadic fetal brain disruption sequence",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015660",
  "properties": {
    "xrefs": [
      "GARD:0018734",
      "MEDGEN:1636968",
      "Orphanet:1665",
      "SCTID:763717004",
      "UMLS:C4706553"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Sporadic fetal brain disruption sequence is a rare, non-syndromic, central nervous system malformation disorder characterized by severe microcephaly (average occipitofrontal circumference -5.8 SD), overlapping sutures, keel-like occipital bone prominence, scalp rugae with normal hair pattern and signs of neurological impairment. Brain imaging may show ventriculomegaly, cortical tissue deficit, and hydranencephaly."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 4657,
      "label": "central nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:331",
          "EFO:0009386",
          "MEDGEN:892343",
          "MESH:D002493",
          "NCIT:C2934",
          "SCTID:23853001",
          "UMLS:C4021765"
        ],
        "synonyms": [
          "CNS disorder",
          "central nervous disease",
          "central nervous system disease",
          "central nervous system disease or disorder",
          "central nervous system disorder",
          "disease of central nervous system",
          "disease of the central nervous system",
          "disease or disorder of central nervous system",
          "disorder of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the central nervous system."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002602"
    }
  ],
  "children": [
    {
      "id": 12604,
      "label": "NDE1-related microhydranencephaly",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16438,
        24511
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010216",
          "MEDGEN:341899",
          "MESH:C537555",
          "OMIM:605013",
          "Orphanet:443162",
          "UMLS:C1857977"
        ],
        "synonyms": [
          "MHAC",
          "hydranencephaly and microcephaly",
          "microhydranencephaly"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "NDE1-related microhydranencephaly is a rare, hereditary syndrome with a central nervous system malformation as major feature characterized by extreme microcephaly and growth restriction, severe motor delay and mental retardation, and typical radiological findings of gross dilation of the ventricles resulting from the absence (or severe delay in the development) of cerebral hemispheres, hypoplasia of the corpus callosum, cerebellum, and brainstem. Associated features are thin bones and scalp rugae."
      },
      "child_count": 0,
      "reference_id": "MONDO:0011504"
    }
  ],
  "roots": [
    {
      "id": 4657,
      "label": "central nervous system disorder"
    }
  ]
}