{
  "id": 16455,
  "label": "myeloid neoplasm associated with PDGFRB rearrangement",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015690",
  "properties": {
    "xrefs": [
      "DOID:0080166",
      "GARD:0020107",
      "ICDO:9966/3",
      "MEDGEN:758646",
      "NCIT:C84276",
      "ONCOTREE:MLNPDGFRB",
      "Orphanet:168950",
      "SCTID:724642009",
      "UMLS:C3472621",
      "icd11.foundation:625932159"
    ],
    "synonyms": [
      "myeloid and lymphoid neoplasms with PDGFRB rearrangement",
      "myeloid neoplasms associated with PDGFRB rearrangement",
      "myeloid neoplasms with PDGFRB rearrangement",
      "myeloid/lymphoid neoplasms with PDGFRB rearrangement",
      "myeloid/lymphoid neoplasm associated with PDGFRB rearrangement"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A rare, malignant, neoplastic disease characterized by clonal proliferation of myeloid and/or lymphoid precursors harboring rearrangements in the PDGFRB gene, in the blood, bone marrow and often other tissues as well (spleen, lymph nodes, skin, etc.). It usually presents as chronic myelomonocytic leukemia with eosinophilia, chronic eosinophilic leukemia, atypical chronic myelogenous leukemia, juvenile myelomonocytic leukemia, myelodysplastic syndrome, acute myeloid leukemia or acute lymphoblastic leukemia. Patients usually present with anemia, leukocytosis, monocytosis, eosinophilia and/or splenomegaly, or systemic symptoms, such as fever, sweating and/or weight loss."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 16453,
      "label": "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080164",
          "GARD:0020105",
          "MEDGEN:417664",
          "NCIT:C84270",
          "Orphanet:168943",
          "UMLS:C2827356"
        ],
        "synonyms": [
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2",
          "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
          "myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement",
          "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0015688"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 16453,
      "label": "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2"
    }
  ]
}