{
  "id": 16456,
  "label": "hypereosinophilic syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015691",
  "properties": {
    "xrefs": [
      "DOID:999",
      "EFO:1001467",
      "GARD:0002804",
      "ICD10CM:D72.11",
      "ICD9:288.3",
      "ICDO:9964/3",
      "MEDGEN:280990",
      "MESH:D017681",
      "MedDRA:10048643",
      "NANDO:2200805",
      "NANDO:2200806",
      "NCIT:C27038",
      "Orphanet:168956",
      "SCTID:419455006",
      "UMLS:C1540912",
      "icd11.foundation:110429919"
    ],
    "synonyms": [
      "HES",
      "hypereosinophilic disease",
      "hypereosinophilic disorder",
      "hypereosinophilic syndrome",
      "eosinophilia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6919
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020535",
          "MEDGEN:1843079",
          "NANDO:1200294",
          "Orphanet:217720",
          "UMLS:C5680885",
          "icd11.foundation:2097520643"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 7,
      "reference_id": "MONDO:0016345"
    },
    {
      "id": 23489,
      "label": "eosinophil disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:739396",
          "SCTID:417967008",
          "UMLS:C1691020"
        ],
        "synonyms": [
          "disease of eosinophil",
          "disease or disorder of eosinophil",
          "disorder of eosinophil",
          "eosinophil disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease or disorder that involves the eosinophil."
      },
      "child_count": 1,
      "reference_id": "MONDO:0044972"
    }
  ],
  "children": [
    {
      "id": 6566,
      "label": "pulmonary eosinophilia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9498",
          "GARD:0024108",
          "ICD9:518.3",
          "MEDGEN:46208",
          "MESH:D011657",
          "SCTID:367542003",
          "UMLS:C0034068",
          "icd11.foundation:544479555"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A condition characterized by infiltration of the lung with eosinophils due to inflammation or other disease processes. Major eosinophilic lung diseases are the eosinophilic pneumonias caused by infections, allergens, or toxic agents."
      },
      "child_count": 1,
      "reference_id": "MONDO:0004802"
    },
    {
      "id": 6567,
      "label": "disseminated eosinophilic collagen disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6394,
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9499",
          "GARD:0024109",
          "ICD9:710.8",
          "MEDGEN:538043",
          "SCTID:423486005",
          "UMLS:C0263662"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0004803"
    },
    {
      "id": 6687,
      "label": "eosinophilia-myalgia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:998",
          "EFO:1001316",
          "GARD:0006345",
          "ICD9:710.5",
          "MEDGEN:38987",
          "MESH:D016603",
          "NORD:1094",
          "SCTID:95416007",
          "UMLS:C0085179",
          "icd11.foundation:1361333197"
        ],
        "synonyms": [
          "eosinophilia myalgia syndrome",
          "EMS",
          "L-tryptophan induced EMS",
          "severe muscle pain and abnormally high eosinophils",
          "syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A complex systemic syndrome with inflammatory and autoimmune components that affect the skin, fascia, muscle, nerve, blood vessels, lung, and heart. Diagnostic features generally include eosinophilia, myalgia severe enough to limit usual activities of daily living, and the absence of coexisting infectious, autoimmune or other conditions that may induce eosinophilia. Biopsy of affected tissue reveals a microangiopathy associated with diffuse inflammation involving connective tissue. (From Spitzer et al., J Rheumatol Suppl 1996 Oct;46:73-9; Blackburn wd, Semin Arthritis Rheum 1997 Jun;26(6):788-93)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004941"
    },
    {
      "id": 12971,
      "label": "idiopathic hypereosinophilic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6836,
        16456,
        16880
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016625",
          "ICD10CM:D72.110",
          "MEDGEN:61525",
          "OMIM:607685",
          "Orphanet:3260",
          "SCTID:423294001",
          "UMLS:C0206141",
          "icd11.foundation:703101846"
        ],
        "synonyms": [
          "hypereosinophilic syndrome, idiopathic, resistant to imatinib, isolated cases, somatic mutation",
          "HES",
          "hypereosinophilic syndrome, idiopathic"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 3,
      "reference_id": "MONDO:0011895"
    },
    {
      "id": 18051,
      "label": "primary hypereosinophilic syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021395",
          "MEDGEN:1830089",
          "Orphanet:314950",
          "UMLS:C5679898"
        ],
        "synonyms": [
          "HES-M",
          "HES-N",
          "clonal hypereosinophilic syndrome",
          "neoplastic hypereosinophilic syndrome",
          "primary HES"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017833"
    },
    {
      "id": 18052,
      "label": "secondary hypereosinophilic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021396",
          "MEDGEN:1814441",
          "Orphanet:314962",
          "UMLS:C5679897"
        ],
        "synonyms": [
          "HES-R",
          "reactive hypereosinophilic syndrome",
          "secondary HES"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0017834"
    },
    {
      "id": 23811,
      "label": "hypereosinophilia of undetermined significance",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026029",
          "MEDGEN:1812275",
          "UMLS:C5666804"
        ],
        "synonyms": [
          "HEUS",
          "benign eosinophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Long-lasting, unexplained and asymptomatic blood hypereosinophilia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0100059"
    },
    {
      "id": 24375,
      "label": "episodic angioedema with eosinophilia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013029",
          "MEDGEN:725561",
          "UMLS:C1304198",
          "icd11.foundation:1511563398"
        ],
        "synonyms": [
          "EAE",
          "Gleich syndrome",
          "Gleich's syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disorder characterized by episodes of swelling under the skin (angioedema) and an elevated number of the white blood cells known as eosinophils (eosinophilia). During these episodes, symptoms of hives (urticaria), fever, swelling, weight gain and eosinophilia may occur. Symptoms usually appear every 3-4 weeks and resolve on their own within several days. Other cells may be elevated during the episodes, such as neutrophils and lymphocytes. Although the syndrome is often considered a subtype of the idiopathic hypereosinophilic syndromes, it does not typically have organ involvement or lead to other health concerns."
      },
      "child_count": 0,
      "reference_id": "MONDO:0500000"
    }
  ],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 16883,
      "label": "non-familial restrictive cardiomyopathy"
    },
    {
      "id": 23489,
      "label": "eosinophil disorder"
    }
  ]
}