{
  "id": 16457,
  "label": "refractory anemia with excess blasts in transformation",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015692",
  "properties": {
    "xrefs": [
      "GARD:0020108",
      "ICD9:238.73",
      "ICDO:9984/3",
      "MEDGEN:124692",
      "MedDRA:10038271",
      "NCIT:C27080",
      "Orphanet:168960",
      "SCTID:110000005",
      "UMLS:C0280028"
    ],
    "synonyms": [
      "RAEB-T",
      "RAEB-t"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Refractory anemia with excess blasts in transformation (RAEB-T) is characterized by dysplastic features of the myeloid and usually erythroid progenitor cells in the bone marrow and an increased number of myeloblasts in the peripheral blood. The peripheral blood blast count ranges from 20% to 30%. RAEB-T used to be a subcategory of myelodysplastic syndromes in the past. Recently, the term has been eliminated from the WHO based classification of myelodysplastic syndromes. The reason is that the percentage of peripheral blood blasts required for the diagnosis of acute myeloid leukemia has been reduced to 20%. The elimination of the RAEB-T term by the WHO experts has created confusion and ongoing arguments. Currently, according to WHO classification, the vast majority of RAEB-T cases are best classified as acute leukemias (acute leukemias with multilineage dysplasia following myelodysplastic syndrome). A minority of cases are part of RAEB-2."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 5945,
      "label": "refractory hematologic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:712",
          "GARD:0023831",
          "MEDGEN:233400",
          "NCIT:C27357",
          "UMLS:C1335724"
        ],
        "synonyms": [
          "refractory hematologic cancer",
          "refractory hematologic malignancy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A hematologic malignancy that is resistant to treatment."
      },
      "child_count": 6,
      "reference_id": "MONDO:0004111"
    },
    {
      "id": 18812,
      "label": "myelodysplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513,
        20301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050908",
          "EFO:0000198",
          "GARD:0007132",
          "ICD10CM:D46",
          "ICD9:238.7",
          "ICD9:238.75",
          "ICDO:9989/3",
          "MEDGEN:483005",
          "MedDRA:10028532",
          "NANDO:2100003",
          "NANDO:2200019",
          "NCIT:C3247",
          "NORD:1480",
          "OMIM:614286",
          "ONCOTREE:MDS",
          "Orphanet:52688",
          "SCTID:109995007",
          "UMLS:C3463824"
        ],
        "synonyms": [
          "MDS",
          "MDS, unclassifiable",
          "MDS-U",
          "Myelodysplastic Syndromes",
          "dysmyelopoietic syndrome",
          "hematopoeitic - myelodysplastic syndrome (MDS)",
          "myelodysplasia",
          "myelodysplastic neoplasm",
          "myelodysplastic syndrome",
          "myelodysplastic syndrome, somatic",
          "myelodysplastic syndrome, unclassifiable",
          "myelodysplastic syndrome/neoplasm",
          "myelodysplastic syndromes",
          "oligoblastic leukaemia",
          "oligoblastic leukemia",
          "preleukemia",
          "smoldering leukemia",
          "smouldering leukaemia",
          "myelodysplastic syndrome, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)"
      },
      "child_count": 16,
      "reference_id": "MONDO:0018881"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 5945,
      "label": "refractory hematologic cancer"
    },
    {
      "id": 18812,
      "label": "myelodysplastic syndrome"
    }
  ]
}