{
  "id": 16513,
  "label": "myeloid hemopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015756",
  "properties": {
    "xrefs": [
      "GARD:0020130",
      "MEDGEN:1842523",
      "Orphanet:171895",
      "UMLS:C5680514"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4440,
      "label": "hematopoietic and lymphoid system neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6798,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2531",
          "GARD:0023120",
          "MEDGEN:268180",
          "MESH:D019337",
          "NCIT:C35813",
          "SCTID:129154003",
          "UMLS:C1512393"
        ],
        "synonyms": [
          "haematopoietic neoplasm",
          "haematopoietic neoplasm (morphologic abnormality)",
          "hematologic neoplasm",
          "hematopoietic neoplasm",
          "hematopoietic neoplasm (morphologic abnormality)",
          "blood neoplasm (disease)",
          "blood tumor",
          "blood tumour",
          "haematological tumours",
          "haematopoietic and lymphoid system tumour",
          "haematopoietic system neoplasm",
          "haematopoietic system tumour",
          "haematopoietic tumours",
          "hematopoietic and lymphoid system neoplasm",
          "hematopoietic and lymphoid system tumor",
          "hematopoietic system neoplasm",
          "hematopoietic system tumor",
          "neoplasm of blood",
          "neoplasm of haematopoietic system",
          "neoplasm of hematopoietic system",
          "tumor of blood",
          "tumor of hematopoietic system",
          "tumour of blood",
          "tumour of haematopoietic system",
          "blood cancer",
          "haematopoietic cancer",
          "hematologic malignancy",
          "hematopoietic cancer",
          "malignant haematopoietic neoplasm (morphologic abnormality)",
          "malignant hematopoietic neoplasm (morphologic abnormality)",
          "hematologic cancer",
          "malignant haematopoietic neoplasm"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Neoplasms of the hematopoietic system, including hematopoietic cell neoplasms (e.g. leukemias, lymphomas) and non-hematopoietic cell neoplasms that can affect the hematopoietic system (e.g. lymph node and splenic sarcomas). --2003"
      },
      "child_count": 18,
      "reference_id": "MONDO:0002334"
    }
  ],
  "children": [
    {
      "id": 16453,
      "label": "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513,
        23467
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080164",
          "GARD:0020105",
          "MEDGEN:417664",
          "NCIT:C84270",
          "Orphanet:168943",
          "UMLS:C2827356"
        ],
        "synonyms": [
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, and FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and abnormalities of PDGFRA, PDGFRB, or FGFR1",
          "myeloid and lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2",
          "myeloid/lymphoid neoplasms associated with eosinophilia and abnormality of PDGFRA, PDGFRB, FGFR1 or JAK2",
          "myeloid/lymphoid neoplasms with eosinophilia and gene rearrangement",
          "myeloid/lymphoid neoplasms with eosinophilia and rearrangement of PDGFRA, PDGFRB, or FGFR1, or with PCM1-JAK2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0015688"
    },
    {
      "id": 18812,
      "label": "myelodysplastic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513,
        20301
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050908",
          "EFO:0000198",
          "GARD:0007132",
          "ICD10CM:D46",
          "ICD9:238.7",
          "ICD9:238.75",
          "ICDO:9989/3",
          "MEDGEN:483005",
          "MedDRA:10028532",
          "NANDO:2100003",
          "NANDO:2200019",
          "NCIT:C3247",
          "NORD:1480",
          "OMIM:614286",
          "ONCOTREE:MDS",
          "Orphanet:52688",
          "SCTID:109995007",
          "UMLS:C3463824"
        ],
        "synonyms": [
          "MDS",
          "MDS, unclassifiable",
          "MDS-U",
          "Myelodysplastic Syndromes",
          "dysmyelopoietic syndrome",
          "hematopoeitic - myelodysplastic syndrome (MDS)",
          "myelodysplasia",
          "myelodysplastic neoplasm",
          "myelodysplastic syndrome",
          "myelodysplastic syndrome, somatic",
          "myelodysplastic syndrome, unclassifiable",
          "myelodysplastic syndrome/neoplasm",
          "myelodysplastic syndromes",
          "oligoblastic leukaemia",
          "oligoblastic leukemia",
          "preleukemia",
          "smoldering leukemia",
          "smouldering leukaemia",
          "myelodysplastic syndrome, susceptibility to"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic disorder characterized by dysplasia and ineffective hematopoiesis in one or more of the hematopoietic cell lines. The dysplasia may be accompanied by an increase in myeloblasts, but the number is less than 20%, which, according to the WHO guidelines, is the requisite threshold for the diagnosis of acute myeloid leukemia. It may occur de novo or as a result of exposure to alkylating agents and/or radiotherapy. (WHO, 2001)"
      },
      "child_count": 16,
      "reference_id": "MONDO:0018881"
    },
    {
      "id": 19727,
      "label": "myeloproliferative neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6892,
        16513,
        20376
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2226",
          "EFO:0002428",
          "GARD:0009319",
          "ICD9:238.79",
          "ICDO:9960/3",
          "ICDO:9975/1",
          "MEDGEN:220955",
          "MedDRA:10028576",
          "NCIT:C4345",
          "ONCOTREE:MPN",
          "Orphanet:98274",
          "SCTID:425333006",
          "UMLS:C1292778"
        ],
        "synonyms": [
          "CMPD",
          "MPD",
          "MPN",
          "chronic myeloproliferative disease",
          "chronic myeloproliferative disorder",
          "chronic myeloproliferative neoplasm",
          "myeloproliferative disorder",
          "myeloproliferative neoplasm",
          "myeloproliferative neoplasm, chronic",
          "myeloproliferative tumor",
          "myeloproliferative tumour",
          "CMPD, U",
          "chronic myeloproliferative disorders",
          "myeloproliferative neoplasms"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A clonal hematopoietic stem cell disorder, characterized by proliferation in the bone marrow of one or more of the myeloid (i.e., granulocytic, erythroid, megakaryocytic, and mast cell) lineages. It is primarily a neoplasm of adults. (WHO 2008)"
      },
      "child_count": 39,
      "reference_id": "MONDO:0020076"
    },
    {
      "id": 19728,
      "label": "myelodysplastic/myeloproliferative disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16513
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009351",
          "MESH:D054437",
          "Orphanet:98275"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Clonal myeloid disorders that possess both dysplastic and proliferative features but are not properly classified as either MYELODYSPLASTIC SYNDROMES or MYELOPROLIFERATIVE disorderS."
      },
      "child_count": 2,
      "reference_id": "MONDO:0020077"
    }
  ],
  "roots": [
    {
      "id": 4440,
      "label": "hematopoietic and lymphoid system neoplasm"
    }
  ]
}