{
  "id": 16516,
  "label": "B-cell non-Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015759",
  "properties": {
    "xrefs": [
      "EFO:1001938",
      "GARD:0020132",
      "NANDO:2200020",
      "NCIT:C3457",
      "Orphanet:171915"
    ],
    "synonyms": [
      "B-cell NHL",
      "B-cell lymphoma",
      "B-cell non Hodgkin's lymphoma",
      "B-cell non-Hodgkin lymphoma",
      "B-cell non-Hodgkin's lymphoma",
      "lymphomas non-Hodgkin's B-cell",
      "non-Hodgkin's B-cell lymphoma",
      "non-Hodgkin's lymphoma B-cell"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "The most common type of non-Hodgkin lymphoma. It includes the most frequently seen morphologic variants which are: diffuse large B-cell lymphoma, follicular lymphoma, small lymphocytic lymphoma and marginal zone B-cell lymphoma. -- 2003"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 5930,
      "label": "B-cell neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6569,
        6792
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:707",
          "GARD:0005877",
          "MEDGEN:86953",
          "MESH:D016393",
          "NCIT:C27907",
          "UMLS:C0079731"
        ],
        "synonyms": [
          "B-cell neoplasm",
          "B-cell lymphoma",
          "lymphoma, B-cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A group of heterogeneous lymphoid tumors generally expressing one or more B-cell antigens or representing malignant transformations of B-lymphocytes."
      },
      "child_count": 10,
      "reference_id": "MONDO:0004095"
    },
    {
      "id": 18836,
      "label": "non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6792
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060060",
          "EFO:0005952",
          "ICDO:9591/3",
          "MEDGEN:6160",
          "MESH:D008228",
          "MedDRA:10029547",
          "NCIT:C3211",
          "ONCOTREE:NHL",
          "Orphanet:547",
          "UMLS:C0024305"
        ],
        "synonyms": [
          "NHL",
          "non-Hodgkin lymphoma",
          "non-Hodgkin's lymphoma",
          "non-Hodgkin's lymphoma (NHL)",
          "non-Hodgkins lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage."
      },
      "child_count": 10,
      "reference_id": "MONDO:0018908"
    }
  ],
  "children": [
    {
      "id": 6692,
      "label": "B-cell acute lymphoblastic leukemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6710,
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080630",
          "DOID:7061",
          "EFO:0000094",
          "GARD:0024135",
          "MEDGEN:226949",
          "NCIT:C8936",
          "SCTID:277571004",
          "UMLS:C1292769"
        ],
        "synonyms": [
          "B lymphoblastic leukemia/lymphoma",
          "precursor B lymphoblastic leukemia/lymphoma",
          "precursor B-lymphoblastic lymphoma/leukemia",
          "precursor B lymphoblastic lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm of lymphoblasts committed to the B-cell lineage, typically composed of small to medium-sized blast cells. When the neoplasm involves predominantly the bone marrow and the peripheral blood, it is called B acute lymphoblastic leukemia. When it involves nodal or extranodal sites, it is called B lymphoblastic lymphoma. (WHO, 2001)"
      },
      "child_count": 32,
      "reference_id": "MONDO:0004947"
    },
    {
      "id": 17874,
      "label": "indolent B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021244",
          "MEDGEN:1741600",
          "NCIT:C171299",
          "Orphanet:300842",
          "UMLS:C5419078"
        ],
        "synonyms": [
          "indolent B-cell NHL",
          "B cell lymphoma, indolent",
          "indolent B cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017594"
    },
    {
      "id": 17875,
      "label": "aggressive B-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021245",
          "MEDGEN:1791561",
          "NCIT:C178541",
          "Orphanet:300846",
          "UMLS:C5555120"
        ],
        "synonyms": [
          "aggressive B-cell NHL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 6,
      "reference_id": "MONDO:0017595"
    },
    {
      "id": 18680,
      "label": "plasma cell leukemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6702,
        6710,
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9513",
          "EFO:0006475",
          "GARD:0009373",
          "ICD10CM:C90.1",
          "ICD9:203.1",
          "ICD9:203.10",
          "ICDO:9733/3",
          "MEDGEN:9733",
          "MESH:D007952",
          "NCIT:C3180",
          "Orphanet:454714",
          "SCTID:95210003",
          "UMLS:C0023484",
          "icd11.foundation:2048216430"
        ],
        "synonyms": [
          "PCL",
          "leukaemia plasmacytic",
          "leukemia plasmacytic",
          "plasma cell leukemia",
          "plasmacytic leukaemia",
          "plasmacytic leukemia",
          "leukemia, plasma cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive plasma cell neoplasm characterized by the presence of neoplastic plasma cells in the peripheral blood. It is characterized by the presence of a circulating clonal plasma cell count that exceeds 2x10^9/L or is 20% of the leukocyte differential count."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018689"
    },
    {
      "id": 23470,
      "label": "central nervous system non-hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4634,
        16516
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025918",
          "MEDGEN:745669",
          "NCIT:C114779",
          "SCTID:448254007",
          "UMLS:C2213246"
        ],
        "synonyms": [
          "Central nervous system non-Hodgkin lymphoma",
          "Primary Central nervous system non-Hodgkin lymphoma",
          "central nervous system non-Hodgkin lymphoma",
          "non-Hodgkin lymphoma of central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A non-Hodgkin lymphoma that arises from the central nervous system."
      },
      "child_count": 4,
      "reference_id": "MONDO:0044887"
    }
  ],
  "roots": [
    {
      "id": 5930,
      "label": "B-cell neoplasm"
    },
    {
      "id": 18836,
      "label": "non-Hodgkin lymphoma"
    }
  ]
}