{
  "id": 16517,
  "label": "T-cell non-Hodgkin lymphoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015760",
  "properties": {
    "xrefs": [
      "DOID:0081312",
      "GARD:0020133",
      "ICD9:202.70",
      "MEDGEN:86957",
      "MESH:D016399",
      "MedDRA:10042971",
      "NCIT:C3466",
      "Orphanet:171918",
      "SCTID:109978004",
      "UMLS:C0079772"
    ],
    "synonyms": [
      "T cell lymphoma",
      "T-cell NHL",
      "T-cell and NK-cell non-Hodgkin lymphoma",
      "T-cell and NK-cell non-Hodgkin's lymphoma",
      "T-cell lymphoma",
      "T-cell non-Hodgkin lymphoma",
      "T-cell non-Hodgkin's lymphoma",
      "non-Hodgkin's T-cell lymphoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "A non-Hodgkin lymphoma of T-cell lineage. It includes the T lymphoblastic lymphoma and the mature T- and NK-cell lymphomas. -- 2003"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 9,
  "parents": [
    {
      "id": 18836,
      "label": "non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6792
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060060",
          "EFO:0005952",
          "ICDO:9591/3",
          "MEDGEN:6160",
          "MESH:D008228",
          "MedDRA:10029547",
          "NCIT:C3211",
          "ONCOTREE:NHL",
          "Orphanet:547",
          "UMLS:C0024305"
        ],
        "synonyms": [
          "NHL",
          "non-Hodgkin lymphoma",
          "non-Hodgkin's lymphoma",
          "non-Hodgkin's lymphoma (NHL)",
          "non-Hodgkins lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Distinct from Hodgkin lymphoma both morphologically and biologically, non-Hodgkin lymphoma (NHL) is characterized by the absence of Reed-Sternberg cells, can occur at any age, and usually presents as a localized or generalized lymphadenopathy associated with fever and weight loss. The clinical course varies according to the morphologic type. NHL is clinically classified as indolent, aggressive, or having a variable clinical course. NHL can be of B-or T-/NK-cell lineage."
      },
      "child_count": 10,
      "reference_id": "MONDO:0018908"
    }
  ],
  "children": [
    {
      "id": 2906,
      "label": "mature T-cell and NK-cell non-Hodgkin lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6891,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050743",
          "DOID:0050749",
          "GARD:0007368",
          "ICD10CM:C84.4",
          "ICDO:9702/3",
          "MEDGEN:1790498",
          "MESH:D016411",
          "NCIT:C3468",
          "SCTID:109977009",
          "UMLS:C5551485"
        ],
        "synonyms": [
          "PTCL",
          "mature T-and NK-cell lymphoma",
          "mature T-cell and NK-cell lymphoma",
          "mature T-cell and NK-cell non-Hodgkin lymphoma",
          "mature T-cell and NK-cell non-Hodgkin's lymphoma",
          "mature T-cell lymphoma",
          "mature T-cell non-Hodgkin's lymphoma",
          "peripheral T-cell lymphoma",
          "NK-T cell lymphoma",
          "mature T-cell and natural killer cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "This type of lymphoma is not frequently seen in the western hemisphere. Clinically, with the exception of anaplastic large cell lymphoma, mature T- and NK-cell lymphomas are among the most aggressive of all hematopoietic neoplasms. Representative disease entities include mycosis fungoides, angioimmunoblastic T-cell lymphoma, hepatosplenic T-cell lymphoma, and anaplastic large cell lymphoma."
      },
      "child_count": 16,
      "reference_id": "MONDO:0000430"
    },
    {
      "id": 16515,
      "label": "primary cutaneous T-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16517,
        18826
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006226",
          "MEDGEN:36336",
          "MedDRA:10011677",
          "Orphanet:171901",
          "UMLS:C0079773"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0015758"
    },
    {
      "id": 19292,
      "label": "CD4+/CD56+ hematodermic neoplasm",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4907,
        6892,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081076",
          "EFO:0010580",
          "GARD:0010556",
          "ICD10CM:C86.4",
          "ICD9:202.80",
          "ICDO:9727/3",
          "MEDGEN:220972",
          "NCIT:C7203",
          "ONCOTREE:BPDCN",
          "Orphanet:86870",
          "SCTID:445105005",
          "UMLS:C1301363",
          "icd11.foundation:783045723"
        ],
        "synonyms": [
          "BPDCN",
          "CD4+/CD56+ hematodermic neoplasm",
          "agranular CD4+ CD56+ hematodermic neoplasm/tumor",
          "agranular CD4+ natural Killer cell leukaemia",
          "agranular CD4+ natural Killer cell leukemia",
          "blastic NK-cell lymphoma",
          "blastic natural Killer leukemia/lymphoma",
          "blastic plasmacytoid Dendritic cell neoplasm",
          "blastic plasmacytoid dendritic cell neoplasm",
          "early plasmacytoid Dendritic cell leukemia/lymphoma",
          "lymphoblastoid variant of NK-cell lymphoma",
          "monomorphic NK-cell lymphoma",
          "primary cutaneous CD4+/CD56+ hematolymphoid neoplasm",
          "blastic plasmacytoid dendritic cell"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aggressive immature hematologic neoplasm formerly known as blastic NK cell lymphoma, composed of cells with a lymphoblast-like morphology. Recent evidence suggests derivation from a plasmacytoid monocyte. Patients present with cutaneous tumors and bone marrow involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019467"
    },
    {
      "id": 19296,
      "label": "adult T-cell leukemia/lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5547,
        7179,
        7417,
        16517,
        17658,
        20413
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050523",
          "GARD:0019076",
          "ICD9:204.80",
          "ICDO:9827/3",
          "MEDGEN:44128",
          "MedDRA:10001413",
          "NCIT:C3184",
          "ONCOTREE:ATLL",
          "Orphanet:86875",
          "SCTID:110007008",
          "UMLS:C0023493",
          "icd11.foundation:430573082"
        ],
        "synonyms": [
          "ATLL",
          "T-cell leukaemia of adults",
          "T-cell leukemia of adults",
          "adult T-cell leukaemia",
          "adult T-cell leukemia",
          "adult T-cell leukemia/lymphoma",
          "HTLV-1 associated adult T-cell lymphoma/leukemia",
          "HTLV-I associated adult T-cell leukemia/lymphoma",
          "adult T cell lymphoma/leukemia",
          "adult T-cell leukemia/lymphoma (HTLV-1 positive)",
          "adult T-cell lymphoma",
          "adult T-cell lymphoma/leukemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A peripheral (mature) T-cell neoplasm linked to the human T-cell leukemia virus type 1 (HTLV-1), adult T-cell leukemia/lymphoma is endemic in several regions of the world, in particular Japan, the Caribbean, and parts of Central Africa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019471"
    },
    {
      "id": 19298,
      "label": "enteropathy-associated T-cell lymphoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009809",
          "ICD10CM:C86.2",
          "ICD9:202.70",
          "ICDO:9717/3",
          "MEDGEN:96832",
          "MESH:D058527",
          "MedDRA:10022703",
          "NCIT:C4737",
          "ONCOTREE:EATL",
          "Orphanet:86880",
          "SCTID:277654008",
          "UMLS:C0456889",
          "icd11.foundation:958629729"
        ],
        "synonyms": [
          "EATL",
          "EATL, type I",
          "ETTL",
          "enteropathy associated T-cell lymphoma",
          "enteropathy-associated T-cell lymphoma, type I",
          "enteropathy-type T-cell lymphoma",
          "intestinal T-cell lymphoma",
          "EATCL",
          "high-grade pleomorphic peripheral T-cell lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An uncommon mature T-cell lymphoma of intraepithelial lymphocytes. It usually arises from the small intestine, most commonly the jejunum or ileum. Other less frequent primary anatomic sites include the duodenum, stomach, colon, or outside the gastrointestinal tract. It is seen with increased frequency in regions with a high prevalence of celiac disease."
      },
      "child_count": 1,
      "reference_id": "MONDO:0019473"
    },
    {
      "id": 19299,
      "label": "hepatosplenic T-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081049",
          "GARD:0019077",
          "ICD10CM:C86.1",
          "ICD9:202.80",
          "ICDO:9716/3",
          "MEDGEN:272711",
          "MedDRA:10066957",
          "NCIT:C8459",
          "ONCOTREE:HSTCL",
          "Orphanet:86882",
          "SCTID:445406001",
          "UMLS:C1333984",
          "icd11.foundation:1301206942"
        ],
        "synonyms": [
          "Hepatosplenic gamma/Delta T-cell lymphoma",
          "HSTCL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An extranodal, mature T-cell non-Hodgkin lymphoma that originates from cytotoxic T-cells, usually of gamma/delta T-cell type. It is characterized by the presence of medium-size neoplastic lymphocytes infiltrating the hepatic sinusoids. A similar infiltrating pattern is also present in the spleen and bone marrow that are usually involved at the time of the diagnosis."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019474"
    },
    {
      "id": 23479,
      "label": "T-lymphoblastic lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        3163,
        5443,
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025922",
          "MEDGEN:266232",
          "NANDO:2200023",
          "NCIT:C6919",
          "SCTID:421246008",
          "UMLS:C1292758"
        ],
        "synonyms": [
          "Precur. T-lymphoblastic lymphoma",
          "T Lymphoblastic lymphoma",
          "T-Lymphoblastic lymphoma",
          "T-lymphoblastic lymphoma",
          "precursor T Lymphoblastic lymphoma",
          "precursor T-Lymphoblastic lymphoma",
          "precursor T-cell Lymphoblastic lymphoma",
          "precursor T-lymphoblastic lymphoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "The most frequent type of lymphoblastic lymphoma. It comprises approximately 85-90% of cases. It is more frequently seen in adolescent males. It frequently presents with a mass lesion in the mediastinum. Pleural effusions are common. (WHO, 2001)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0044917"
    },
    {
      "id": 25817,
      "label": "Nodal T-follicular helper cell lymphoma, follicular type",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026926",
          "MEDGEN:398050",
          "NCIT:C80375",
          "Orphanet:652650",
          "UMLS:C2700204"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958095"
    },
    {
      "id": 25818,
      "label": "monomorphic epitheliotropic intestinal T-cell lymphoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16517
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026927",
          "MEDGEN:474158",
          "NCIT:C96058",
          "Orphanet:652658",
          "UMLS:C3272525"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0958096"
    }
  ],
  "roots": [
    {
      "id": 18836,
      "label": "non-Hodgkin lymphoma"
    }
  ]
}