{
  "id": 16610,
  "label": "aplastic anemia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015909",
  "properties": {
    "xrefs": [
      "DOID:12449",
      "GARD:0020234",
      "ICD9:284.8",
      "ICD9:284.9",
      "MEDGEN:8063",
      "MESH:D000741",
      "NANDO:1200295",
      "NANDO:1200301",
      "NANDO:2100201",
      "NANDO:2200693",
      "NCIT:C2870",
      "OMIM:609135",
      "Orphanet:182040",
      "SCTID:306058006",
      "UMLS:C0002874"
    ],
    "categories": [
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Anemia resulting from bone marrow failure (aplastic or hypoplastic bone marrow). The production of erythroblasts and red cells is markedly decreased, and it may be associated with decreased production of granulocytes (granulocytopenia) and platelets (thrombocytopenia) as well. Aplastic anemia may be idiopathic or secondary due to bone marrow damage by toxins, radiation, or immunologic factors."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 4394,
      "label": "anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2355",
          "HP:0001903",
          "ICD9:285.8",
          "ICD9:285.9",
          "MEDGEN:1526",
          "MESH:D000740",
          "NCIT:C2869",
          "SCTID:271737000",
          "UMLS:C0002871"
        ],
        "synonyms": [
          "anaemia (disease)",
          "anemia",
          "anemia (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A reduction in the number of red blood cells, the amount of hemoglobin, and/or the volume of packed red blood cells. Clinically, anemia represents a reduction in the oxygen-transporting capacity of a designated volume of blood, resulting from an imbalance between blood loss (through hemorrhage or hemolysis) and blood production. Signs and symptoms of anemia may include pallor of the skin and mucous membranes, shortness of breath, palpitations of the heart, soft systolic murmurs, lethargy, and fatigability."
      },
      "child_count": 19,
      "reference_id": "MONDO:0002280"
    }
  ],
  "children": [
    {
      "id": 3901,
      "label": "inherited aplastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:1342",
          "GARD:0018889",
          "ICD10CM:D61.0",
          "ICD9:284.0",
          "ICD9:284.09",
          "MEDGEN:1826154",
          "MESH:D029502",
          "NANDO:1200302",
          "NANDO:2201275",
          "Orphanet:397692",
          "Orphanet:68383",
          "SCTID:28975000",
          "UMLS:C5681331"
        ],
        "synonyms": [
          "constitutional aplastic anaemia",
          "constitutional aplastic anemia",
          "hereditary aplastic anaemia",
          "hereditary aplastic anemia",
          "rare constitutional aplastic anaemia",
          "rare constitutional aplastic anemia",
          "congenital aplastic anaemia",
          "congenital aplastic anemia",
          "congenital hypoplastic anaemia",
          "congenital hypoplastic anemia",
          "hypoplastic anaemia - familial",
          "hypoplastic anemia - familial"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An inborn condition characterized by deficiencies of red cell precursors that sometimes also includes leukopenia and thrombocytopenia."
      },
      "child_count": 10,
      "reference_id": "MONDO:0001713"
    },
    {
      "id": 7476,
      "label": "myelophthisic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2354",
          "EFO:0007388",
          "GARD:0024247",
          "ICD10CM:D61.82",
          "ICD9:285.8",
          "MEDGEN:1529",
          "MESH:D000750",
          "SCTID:2694001",
          "UMLS:C0002890"
        ],
        "synonyms": [
          "anaemia LEUKOERYTHROBLASTIC",
          "anemia LEUKOERYTHROBLASTIC",
          "leukoerythroblastic reaction"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An aplastic anemia that is characterized by displacement of hemopoietic bone-marrow tissue either by fibrosis, tumors or granulomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005868"
    },
    {
      "id": 13259,
      "label": "idiopathic aplastic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16610,
        24405
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0005836",
          "ICD10CM:D61.3",
          "MEDGEN:87595",
          "MESH:C538494",
          "NANDO:1200296",
          "NANDO:2201276",
          "NCIT:C61230",
          "Orphanet:88",
          "SCTID:191256002",
          "UMLS:C0348890",
          "icd11.foundation:1615519452"
        ],
        "synonyms": [
          "idiopathic aplastic aplasia",
          "idiopathic bone marrow failure",
          "anaemia aplastic",
          "anemia aplastic",
          "aplastic Anemia, susceptibility to",
          "aplastic anaemia",
          "aplastic anaemia idiopathic",
          "aplastic anemia",
          "aplastic anemia idiopathic",
          "secondary aplastic anaemia",
          "secondary aplastic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Aplastic anemia without a known cause."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012197"
    },
    {
      "id": 16404,
      "label": "acquired aplastic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16610
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020058",
          "MEDGEN:543648",
          "NANDO:2201277",
          "Orphanet:164823",
          "SCTID:55907008",
          "UMLS:C0271907"
        ],
        "synonyms": [
          "acquired aplastic anemia",
          "rare acquired aplastic anaemia",
          "rare acquired aplastic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An instance of aplastic anemia that is acquired during the lifetime of the individual."
      },
      "child_count": 3,
      "reference_id": "MONDO:0015610"
    }
  ],
  "roots": [
    {
      "id": 4394,
      "label": "anemia"
    }
  ]
}