{
  "id": 16613,
  "label": "acquired peripheral neuropathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015923",
  "properties": {
    "xrefs": [
      "MEDGEN:1842976",
      "Orphanet:182086",
      "UMLS:C5680596"
    ],
    "synonyms": [
      "acquired peripheral neuropathy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An instance of peripheral neuropathy that is acquired during the lifetime of the individual."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 12,
  "parents": [
    {
      "id": 6950,
      "label": "peripheral neuropathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5512,
        18957
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:870",
          "EFO:0003100",
          "MEDGEN:18386",
          "MedDRA:10034606",
          "NCIT:C119734",
          "NCIT:C4731",
          "SCTID:302226006",
          "SCTID:386033004",
          "UMLS:C0031117"
        ],
        "synonyms": [
          "neuropathy",
          "peripheral nerve disorder",
          "peripheral neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder affecting the peripheral nervous system. It manifests with pain, tingling, numbness, and muscle weakness. It may be the result of physical injury, toxic substances, viral diseases, diabetes, renal failure, cancer, and drugs."
      },
      "child_count": 60,
      "reference_id": "MONDO:0005244"
    }
  ],
  "children": [
    {
      "id": 16770,
      "label": "axonal polyneuropathy associated with IgG/IgM/IgA monoclonal gammopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020415",
          "MEDGEN:1876718",
          "Orphanet:209004",
          "UMLS:C6012217"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016176"
    },
    {
      "id": 16906,
      "label": "cranial neuralgia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5469,
        16613,
        20717
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020542",
          "MEDGEN:507603",
          "Orphanet:221109",
          "SCTID:23096007",
          "UMLS:C0010269"
        ],
        "synonyms": [
          "cranial neuron projection bundle neuralgia",
          "neuralgia of cranial neuron projection bundle",
          "facial neuralgia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A neuralgia that involves the cranial neuron projection bundle."
      },
      "child_count": 12,
      "reference_id": "MONDO:0016374"
    },
    {
      "id": 17678,
      "label": "neuralgic amyotrophy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0004228",
          "ICD10CM:G54.5",
          "MEDGEN:307145",
          "MedDRA:10063020",
          "NORD:1560",
          "Orphanet:2901",
          "UMLS:C1510479",
          "icd11.foundation:302246011"
        ],
        "synonyms": [
          "brachial plexus neuritis",
          "Parsonage Turner Syndrome",
          "acute brachial plexus neuritis",
          "immune brachial plexus neuropathy",
          "mononeuritis multiplex with brachial predilection",
          "neuralgic shoulder amyotrophy"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Neuralgic amyotrophy (NA) is an uncommon disorder of the peripheral nervous system characterized by the sudden onset of extreme pain in the upper extremity followed by rapid multifocal motor weakness and atrophy and a slow recovery in months to years. NA includes both an idiopathic (INA, also known as Parsonage-Turner syndrome) and hereditary (HNA) form."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017362"
    },
    {
      "id": 17680,
      "label": "POEMS syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6569,
        16613,
        18348,
        24647,
        24648
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14039",
          "EFO:1001115",
          "GARD:0007411",
          "MEDGEN:39276",
          "MESH:D016878",
          "MedDRA:10053869",
          "NANDO:1200033",
          "NCIT:C80303",
          "NORD:1586",
          "Orphanet:2905",
          "SCTID:79268002",
          "UMLS:C0085404",
          "icd11.foundation:1555299114"
        ],
        "synonyms": [
          "Crow-Fukase syndrome",
          "PEP syndrome",
          "POEMS syndrome",
          "Takatsuki syndrome",
          "osteosclerotic myeloma",
          "polyneuropathy-endocrinopathy-plasma cell dyscrasia syndrome",
          "polyneuropathy organomegaly",
          "polyneuropathy, organomegaly, endocrinopathy, M protein, and skin changes syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "POEMS syndrome is a paraneoplastic syndrome characterized by polyradiculoneuropathy (P), organomegaly (O), endocrinopathy (E), clonal plasma cell disorder (M), and skin changes (S). Other features include papilledema, extravascular volume overload, sclerotic bone lesions, thrombocytosis/erythrocytosis, and elevated VEGF levels."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017364"
    },
    {
      "id": 18590,
      "label": "non-recovering obstetric brachial plexus lesion",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021826",
          "MEDGEN:1810145",
          "Orphanet:439202",
          "UMLS:C5680048"
        ],
        "synonyms": [
          "chronic obstetric brachial plexus injury",
          "chronic obstetric brachial plexus palsy",
          "non-recovering OBPI",
          "non-recovering OBPL"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018587"
    },
    {
      "id": 18805,
      "label": "anterior cutaneous nerve entrapment syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018843",
          "MEDGEN:581659",
          "Orphanet:51890",
          "UMLS:C0393899"
        ],
        "synonyms": [
          "ACNES",
          "intercostal nerve syndrome",
          "rectus abdominis syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anterior cutaneous nerve entrapment syndrome (ACNES) is a chronic neuropathic pain syndrome of the abdominal wall caused by entrapment of anterior cutaneous branches of 7 to 12th intercostal nerves along the lateral border of the anterior rectus abdominis fascia causing severe pain and tenderness of the involved dermatome."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018873"
    },
    {
      "id": 18879,
      "label": "pudendal neuralgia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613,
        20717
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010713",
          "ICD9:729.2",
          "MEDGEN:372681",
          "MESH:D060545",
          "Orphanet:60039",
          "SCTID:427972000",
          "UMLS:C1997249",
          "icd11.foundation:1492963618"
        ],
        "synonyms": [
          "Alcock syndrome",
          "Pudendalgia",
          "neuralgia of pudendal nerve",
          "pudendal algia",
          "pudendal nerve entrapment syndrome",
          "pudendal nerve neuralgia",
          "pudendal neuralgia by pudendal nerve entrapment"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Pudendal neuralgia (PN) is a chronic neuropathic pain, aggravated by sitting and for which no organic cause can be found by imaging studies. It is often associated with pelvic dysfunction."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018957"
    },
    {
      "id": 18896,
      "label": "polyneuropathy associated with IgM monoclonal gammapathy with anti-MAG",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013173",
          "MEDGEN:1434346",
          "Orphanet:639",
          "UMLS:C1736154"
        ],
        "synonyms": [
          "anti-MAG neuropathy",
          "neuropathy associated with monoclonal IgM antibodies to myelin-associated glycoprotein"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Polyneuropathy associated with IgM monoclonal gammapathy (MG) with anti-MAG (myelin-associated-glycoprotein) activity is a demyelinating polyneuropathy characterized clinically by sensory ataxia, tremor, paresthesia, and impaired gait."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018977"
    },
    {
      "id": 18898,
      "label": "multifocal motor neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0011011",
          "ICD10CM:G61.82",
          "ICD9:357.89",
          "MEDGEN:581615",
          "NANDO:1200031",
          "NORD:1952",
          "Orphanet:641",
          "SCTID:230591002",
          "UMLS:C0393847"
        ],
        "synonyms": [
          "MMN",
          "MMNCB",
          "multifocal motor neuropathy with conduction block"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Multifocal motor neuropathy (MMN) is a rare acquired immune-mediatedneuropathy characterized clinically by a purely motor deficit with conduction block and asymmetric multifocal weakness, fasciculations, and cramping."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018979"
    },
    {
      "id": 18994,
      "label": "CANOMAD syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009778",
          "MEDGEN:419872",
          "MESH:C537980",
          "Orphanet:71279",
          "SCTID:715624006",
          "UMLS:C2931684"
        ],
        "synonyms": [
          "chronic ataxic neuropathy-ophthalmoplegia-IgM paraprotein-cold agglutinins-disialosyl antibodies syndrome",
          "chronic sensory ataxic neuropathy with anti-dyalosyl IgM antibodies",
          "chronic ataxic neuropathy ophthalmoplegia M-protein agglutination disialosyl antibodies syndrome",
          "chronic sensory ataxic neuropathy with anti-disialosyl antibodies"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "CANOMAD syndrome (Chronic Ataxic Neuropathy, Ophthalmoplegia, Monoclonal IgM protein, cold Agglutinins and Disialosyl antibodies) is a rare chronic immune-mediated demyelinating polyneuropathy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019109"
    },
    {
      "id": 19399,
      "label": "simple cryoglobulinemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025143",
          "MEDGEN:1383731",
          "Orphanet:91139",
          "SCTID:723674005",
          "UMLS:C4510006"
        ],
        "synonyms": [
          "cryoglobulinemia type 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Simple (monoclonal) cryoglobulinemia or type I cryoglobulinemia refers to the presence in the serum of one isotype or subclass of immunoglobulin (Ig) that precipitates reversibly below 37°C."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019606"
    },
    {
      "id": 22746,
      "label": "radiation-induced plexopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16613,
        21410,
        24354
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022137",
          "MEDGEN:1809151",
          "Orphanet:521123",
          "UMLS:C5681446"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare radiation-induced disorder characterized by impairment of the peripheral nervous system at the level of the brachial or lumbosacral plexus following radiation therapy. Onset of symptoms can occur between several months up to decades after the last dose of radiation. Patients with radiation-induced brachial plexopathy typically present with mostly unilateral progressive paresthesia, followed by weakness, atrophy, and pain. Symptoms in radiation-induced lumbosacral plexopathy include more variable combinations of numbness, paresthesia, pain, and weakness, and are more often bilateral."
      },
      "child_count": 0,
      "reference_id": "MONDO:0033838"
    }
  ],
  "roots": [
    {
      "id": 6950,
      "label": "peripheral neuropathy"
    }
  ]
}