{
  "id": 16615,
  "label": "interstitial lung disease",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015925",
  "properties": {
    "xrefs": [
      "DOID:3082",
      "EFO:0004244",
      "ICD10CM:J80-J84",
      "MEDGEN:1788738",
      "MESH:D017563",
      "MedDRA:10022611",
      "NCIT:C164315",
      "Orphanet:182095",
      "SCTID:233703007",
      "UMLS:C5441745"
    ],
    "synonyms": [
      "ILD",
      "interstitial lung disease"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 6971,
      "label": "lung disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        2809
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:850",
          "EFO:0003818",
          "ICD9:518.89",
          "MEDGEN:7399",
          "MESH:D008171",
          "NCIT:C3198",
          "SCTID:19829001",
          "UMLS:C0024115"
        ],
        "synonyms": [
          "disease of lung",
          "disease or disorder of lung",
          "disorder of lung",
          "lung disease",
          "lung disease or disorder",
          "lung disorder",
          "lung disorders",
          "pulmonary disease",
          "pulmonary diseases",
          "pulmonary disorder",
          "pulmonary disorders"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A disease involving the lung."
      },
      "child_count": 33,
      "reference_id": "MONDO:0005275"
    }
  ],
  "children": [
    {
      "id": 4804,
      "label": "pulmonary fibrosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3770",
          "EFO:0009448",
          "GARD:0023241",
          "MEDGEN:11028",
          "MESH:D011658",
          "NCIT:C26869",
          "SCTID:51615001",
          "UMLS:C0034069"
        ],
        "synonyms": [
          "pulmonary interstitial fibrosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Chronic progressive interstitial lung disorder characterized by the replacement of the lung tissue by connective tissue, leading to progressive dyspnea, respiratory failure, or right heart failure. Causes include chronic inflammatory processes, exposure to environmental irritants, radiation therapy, autoimmune disorders, certain drugs, or it may be idiopathic (no identifiable cause)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002771"
    },
    {
      "id": 16149,
      "label": "bronchiolitis obliterans syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4545,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2799",
          "EFO:0007183",
          "GARD:0005961",
          "HP:0011946",
          "ICD9:466.19",
          "ICD9:491.8",
          "MEDGEN:665",
          "NANDO:1200745",
          "NANDO:2100039",
          "NANDO:2200209",
          "Orphanet:1303",
          "SCTID:40100001",
          "UMLS:C0006272",
          "icd11.foundation:592711730"
        ],
        "synonyms": [
          "BOOP",
          "constrictive bronchiolitis",
          "organised pneumonia",
          "organized pneumonia",
          "bronchiolitis obliterans with obstructive pulmonary disease",
          "BO",
          "bronchiolitis exudativa",
          "bronchiolitis obliterans",
          "obliterative bronchiolitis",
          "organising pneumonia",
          "organizing pneumonia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung disorder that is mainly associated with chronic allograft dysfunction after lung transplantation and that is characterized by inflammation and fibrosis of bronchiolar walls that reduce the diameter of the bronchioles and result in progressive and irreversible airflow obstruction."
      },
      "child_count": 4,
      "reference_id": "MONDO:0015265"
    },
    {
      "id": 16616,
      "label": "pneumoconiosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10316",
          "GARD:0020245",
          "ICD9:505",
          "MEDGEN:19360",
          "MESH:D011009",
          "MedDRA:10035653",
          "NCIT:C26861",
          "Orphanet:182098",
          "SCTID:40122008",
          "UMLS:C0032273",
          "icd11.foundation:611962875"
        ],
        "synonyms": [
          "Black lung disease",
          "coal worker's pneumoconiosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An occupational lung disorder caused by inhalation of dust particles. It is characterized by bilateral interstitial lung infiltrates. Representative examples include asbestosis, silicosis, anthracosis, and talc pneumoconiosis."
      },
      "child_count": 14,
      "reference_id": "MONDO:0015926"
    },
    {
      "id": 16797,
      "label": "pulmonary fibrosis-hepatic hyperplasia-bone marrow hypoplasia syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020449",
          "MEDGEN:1385709",
          "Orphanet:210136",
          "UMLS:C4510085"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Pulmonary fibrosis - hepatic hyperplasia - bone marrow hypoplasia, also named Btrimorphic syndromeB (i.e. three (inherited) morbidities, pulmonary, hepatic and cytopenia), is a rare disease reported in 4 cases to date, manifesting with idiopathic pulmonary fibrosis, hepatic nodular regenerative hyperplasia leading to portal hypertension and thrombocytopenia due to bone marrow hypoplasia. The condition was associated with 100% mortality."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016214"
    },
    {
      "id": 17416,
      "label": "interstitial lung disease specific to childhood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842412",
          "Orphanet:264656",
          "SCTID:328661000119108",
          "UMLS:C5679752"
        ],
        "synonyms": [
          "ILD specific to childhood",
          "chILD",
          "chILD syndrome",
          "childhood interstitial lung disease",
          "interstitial lung disease of childhood",
          "paediatric interstitial lung disease",
          "pediatric interstitial lung disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A interstitial lung disease that occurs during childhood."
      },
      "child_count": 5,
      "reference_id": "MONDO:0017014"
    },
    {
      "id": 17418,
      "label": "isolated pulmonary capillaritis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020924",
          "ICD9:448.9",
          "MEDGEN:842738",
          "Orphanet:264691",
          "SCTID:707436001",
          "UMLS:C3873357",
          "icd11.foundation:1607123556",
          "icd11.foundation:1610022220"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Isolated pauciimmune pulmonary capillaritis is a small vessel vasculitis restricted to the lungs that may induce diffuse alveolar hemorrhage with dyspnea, anemia, chest pain, hemoptysis, bilateral and diffuse alveolar infiltrates at chest X-rays, without any underlying systemic disease. ANCA are frequently positive but could be negative."
      },
      "child_count": 0,
      "reference_id": "MONDO:0017018"
    },
    {
      "id": 17421,
      "label": "interstitial lung disease specific to adulthood",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1842399",
          "Orphanet:264735",
          "UMLS:C5679743"
        ],
        "synonyms": [
          "ILD specific to adulthood"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0017026"
    },
    {
      "id": 17423,
      "label": "drug or radiation exposure-related interstitial lung disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020942",
          "MEDGEN:1843006",
          "Orphanet:264978",
          "UMLS:C5680746"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017039"
    },
    {
      "id": 18069,
      "label": "hypersensitivity pneumonitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3133,
        16615,
        23261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:841",
          "GARD:0000012",
          "ICD9:495",
          "ICD9:495.8",
          "ICD9:495.9",
          "MEDGEN:1446",
          "MESH:D000542",
          "MedDRA:10001890",
          "NCIT:C34369",
          "NORD:761",
          "Orphanet:31740",
          "SCTID:37471005",
          "UMLS:C0002390"
        ],
        "synonyms": [
          "HP",
          "allergic form of pneumonitis",
          "allergic pneumonitis",
          "exogen allergic alveolitis",
          "extrinsic allergic alveolitis",
          "hypersensitivity pneumonitis",
          "allergic interstitial pneumonitis",
          "alveolitis, extrinsic allergic",
          "extrinsic allergic pneumonia hypersensitivity pneumonitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Hypersensitivity pneumonitis (HP) is a pulmonary disease with symptoms of dyspnea and cough resulting from the inhalation of an antigen to which the subject has been previously sensitized."
      },
      "child_count": 42,
      "reference_id": "MONDO:0017853"
    },
    {
      "id": 19995,
      "label": "secondary pulmonary hemosiderosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019713",
          "MEDGEN:909854",
          "Orphanet:99930",
          "SCTID:716712004",
          "UMLS:C4274326",
          "icd11.foundation:878618614"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Secondary pulmonary hemosiderosis is a respiratory disease due to the deposition of hemosiderin-laden macrophages in lungs as a result of repeated alveolar hemorrhage secondary to another disease, especially dysimmunitary disorders (i.e. Heiner syndrome, autoimmune diseases), thrombotic disorders and cardiovascular disorders such as mitral stenosis. It manifests as a triad of hemoptysis, anemia and diffuse parenchymal infiltrates on chest radiography"
      },
      "child_count": 1,
      "reference_id": "MONDO:0020553"
    },
    {
      "id": 22225,
      "label": "inherited interstitial lung disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027936",
          "OMIMPS:619611"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An instance of interstitial lung disease that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 26,
      "reference_id": "MONDO:0031199"
    },
    {
      "id": 23262,
      "label": "radiation pneumonitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16615,
        23212,
        23261
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025873",
          "MESH:D017564",
          "SCTID:84004001",
          "icd11.foundation:1914397767"
        ],
        "synonyms": [
          "radiation pneumonitis",
          "Pneumonias, radiation",
          "Pneumonitides, radiation",
          "fibrosis, radiation",
          "pneumonia, radiation",
          "pneumonitis, radiation",
          "pulmonary radiation alveolitis",
          "radiation Pneumonias",
          "radiation Pneumonitides",
          "radiation fibrosis",
          "radiation pneumonia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Inflammation of the lung due to harmful effects of ionizing or non-ionizing radiation."
      },
      "child_count": 0,
      "reference_id": "MONDO:0043919"
    },
    {
      "id": 24829,
      "label": "bronchiolocentric pattern of interstitial pneumonia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6953,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026442"
        ],
        "synonyms": [
          "BPIP"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An interstitial lung disease characterized histologically by fibrosis and/or inflammation confined to the alveolar interstitium around bronchovascular bundles, overlapping with peribronchial metaplasia, fibrosis in some series and the lack of interstitial granulomas."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800123"
    },
    {
      "id": 25088,
      "label": "idiopathic pulmonary fibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4517,
        16615
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050156",
          "GARD:0028067",
          "ICD10CM:J84.112",
          "MEDGEN:321462",
          "MESH:D054990",
          "NCIT:C35716",
          "Orphanet:2032",
          "UMLS:C1800706",
          "icd11.foundation:1074069640"
        ],
        "synonyms": [
          "IPF"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An interstitial lung disease with a poor prognosis, that is characterized by the progressive formation of scar tissue within the lungs in the absence of any known cause."
      },
      "child_count": 0,
      "reference_id": "MONDO:0800504"
    }
  ],
  "roots": [
    {
      "id": 6971,
      "label": "lung disorder"
    }
  ]
}