{
  "id": 16616,
  "label": "pneumoconiosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0015926",
  "properties": {
    "xrefs": [
      "DOID:10316",
      "GARD:0020245",
      "ICD9:505",
      "MEDGEN:19360",
      "MESH:D011009",
      "MedDRA:10035653",
      "NCIT:C26861",
      "Orphanet:182098",
      "SCTID:40122008",
      "UMLS:C0032273",
      "icd11.foundation:611962875"
    ],
    "synonyms": [
      "Black lung disease",
      "coal worker's pneumoconiosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005087",
        "name": "respiratory system disorder"
      }
    ],
    "definition": "An occupational lung disorder caused by inhalation of dust particles. It is characterized by bilateral interstitial lung infiltrates. Representative examples include asbestosis, silicosis, anthracosis, and talc pneumoconiosis."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 14,
  "parents": [
    {
      "id": 16615,
      "label": "interstitial lung disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6971
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3082",
          "EFO:0004244",
          "ICD10CM:J80-J84",
          "MEDGEN:1788738",
          "MESH:D017563",
          "MedDRA:10022611",
          "NCIT:C164315",
          "Orphanet:182095",
          "SCTID:233703007",
          "UMLS:C5441745"
        ],
        "synonyms": [
          "ILD",
          "interstitial lung disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A diverse group of lung diseases that affect the lung parenchyma. They are characterized by an initial inflammation of pulmonary alveoli that extends to the interstitium and beyond leading to diffuse pulmonary fibrosis. Interstitial lung diseases are classified by their etiology (known or unknown causes), and radiological-pathological features."
      },
      "child_count": 14,
      "reference_id": "MONDO:0015925"
    }
  ],
  "children": [
    {
      "id": 3264,
      "label": "mixed mineral dust pneumoconiosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10319",
          "GARD:0022861",
          "ICD9:503",
          "MEDGEN:137937",
          "NCIT:C27559",
          "SCTID:233759002",
          "UMLS:C0340184"
        ],
        "synonyms": [
          "mineral duct pneumoconiosis",
          "mineral dust pneumoconiosis",
          "mixed mineral dust pneumoconiosis",
          "pneumoconiosis from mineral dust"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Pneumoconiosis caused by the inhalation of mixed mineral dust particles."
      },
      "child_count": 1,
      "reference_id": "MONDO:0001000"
    },
    {
      "id": 3265,
      "label": "baritosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10321",
          "GARD:0008371",
          "ICD9:503",
          "MEDGEN:87399",
          "MESH:C537080",
          "NCIT:C34410",
          "SCTID:50076003",
          "UMLS:C0340177"
        ],
        "synonyms": [
          "deposition of barium in the lungs",
          "inhalation of barytes"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A rare type of pneumoconiosis caused by long standing exposure to barium dust. It is characterized by the formation of fine dense lesions in the lung parenchyma. The lesions do not affect the lung function and disappear without treatment after the exposure to barium dust stops."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001001"
    },
    {
      "id": 3266,
      "label": "pneumoconiosis due to talc",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10329",
          "GARD:0022862",
          "ICD9:502",
          "MEDGEN:65961",
          "NCIT:C27026",
          "SCTID:73144008",
          "UMLS:C0238377",
          "icd11.foundation:29181140"
        ],
        "synonyms": [
          "talc pneumoconiosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Pneumoconiosis caused by exposure to talc. It is characterized by fibrosis and granulomatous changes in the lung parenchyma. Chest x-rays reveal diffuse lung opacities and pleural abnormalities."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001003"
    },
    {
      "id": 3267,
      "label": "slate pneumoconiosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10330",
          "GARD:0022863",
          "ICD9:502",
          "MEDGEN:83300",
          "NCIT:C35397",
          "SCTID:1259003",
          "UMLS:C0340186"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Pneumoconiosis caused by exposure to slate dust."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001004"
    },
    {
      "id": 7321,
      "label": "Caplan syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10326",
          "EFO:0007192",
          "GARD:0024218",
          "MEDGEN:743",
          "MESH:D002205",
          "SCTID:398640008",
          "UMLS:C0006915"
        ],
        "synonyms": [
          "Caplan's syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A combination of rheumatoid arthritis (RA) and pneumoconiosis that manifests as intrapulmonary nodules, which appear homogenous and well-defined on chest X-ray."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005690"
    },
    {
      "id": 7552,
      "label": "silicosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10325",
          "EFO:0007485",
          "GARD:0007647",
          "ICD9:502",
          "MEDGEN:20758",
          "MESH:D012829",
          "NCIT:C3369",
          "SCTID:805002",
          "UMLS:C0037116"
        ],
        "synonyms": [
          "pneumoconiosis due to silica",
          "silicosis",
          "silicotuberculosis",
          "accelerated silicosis",
          "acute silicosis",
          "chronic silicosis",
          "experimental silicosis",
          "nodular silicosis",
          "pneumoconiosis caused by silica",
          "silicatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Silicosis is a respiratory disease caused by breathing in (inhaling) silica dust. There are three types of silicosis: Simple chronic silicosis, the most common type of silicosis, results from long-term exposure (usually more than 20years) to low amounts of silica dust. Simple chronic silicosismay causepeople to have difficulty breathing. Accelerated silicosis occurs after 5 to 15 yearsof exposure of higher levels of silica.Swelling of the lungsand other symptoms occur faster in this type of silicosis than in the simple chronic form. Acute silicosis results from short-term exposure (weeks or months) of large amounts of silica.The lungs become very inflamed and can fill with fluid, causing severe shortness of breath and low blood oxygen levels. A cough, weight loss, and fatigue may also be present. Acute silicosis progresses rapidly and can be fatal within months. People who work in jobs where they are exposed to silica dust (mining, quarrying, construction, sand blasting, stone cutting) are at risk of developing this condition."
      },
      "child_count": 2,
      "reference_id": "MONDO:0005960"
    },
    {
      "id": 8125,
      "label": "anthracosilicosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2596-4484",
          "DOID:10324",
          "EFO:1000813",
          "GARD:0024453",
          "MEDGEN:1958",
          "MESH:D000874",
          "MedDRA:10050363",
          "NCIT:C34389",
          "SCTID:33548005",
          "UMLS:C0003164"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Fibrosis of the lung parenchyma caused by inhalation of carbon and silica dust. It manifests as shortness of breath."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006653"
    },
    {
      "id": 8126,
      "label": "anthracosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10327",
          "EFO:1000814",
          "GARD:0024454",
          "ICD10CM:J60",
          "ICD9:500",
          "MEDGEN:8107",
          "MESH:D055008",
          "MedDRA:10073051",
          "NCIT:C34390",
          "SCTID:29422001",
          "UMLS:C0003165"
        ],
        "synonyms": [
          "coal dust pneumoconiosis",
          "coal miner's pneumoconiosis",
          "coal workers' pneumoconiosis",
          "pneumoconiosis from coal dust"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A chronic lung disorder characterized by deposition of coal dust in the lung parenchyma leading to the formation of black nodules and emphysema. It occurs in coal miners."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006654"
    },
    {
      "id": 8155,
      "label": "byssinosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10323",
          "EFO:1000851",
          "GARD:0005976",
          "ICD10CM:J66.0",
          "ICD9:504",
          "MEDGEN:2769",
          "MESH:D002095",
          "MedDRA:10006822",
          "NCIT:C84605",
          "SCTID:13151001",
          "UMLS:C0006542"
        ],
        "synonyms": [
          "cotton dust pneumoconiosis",
          "pneumoconiosis from cotton dust",
          "textile worker's lung",
          "Monday morning fever"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "An occupational lung disorder caused by exposure to cotton dust. It occurs more commonly in workers in the textile industry. Signs and symptoms include chest tightness, cough and wheezing. The symptoms tend to get worse at the beginning of the week and subside by the end of the week."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006688"
    },
    {
      "id": 9649,
      "label": "pulmonary hemosiderosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3654,
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10328",
          "DOID:12118",
          "GARD:0006763",
          "ICD10CM:J84.03",
          "ICD9:516.1",
          "MEDGEN:9403",
          "MESH:D012806",
          "NANDO:1200751",
          "NANDO:2100037",
          "NANDO:2200207",
          "NORD:91174",
          "OMIM:178550",
          "Orphanet:99931",
          "SCTID:40527005",
          "UMLS:C0020807",
          "icd11.foundation:1542272036"
        ],
        "synonyms": [
          "Idiopathic Pulmonary Hemosiderosis",
          "idiopathic pulmonary hemosiderosis",
          "pulmonary hemosiderosis",
          "pulmonary siderosis",
          "alveolar hypoventilation syndrome",
          "siderosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A respiratory disease due to repeated episodes of diffuse alveolar hemorrhage without any underlying apparent cause, most often in children. Anemia, cough, and pulmonary infiltrates on chest radiographs are found in majority of the patients."
      },
      "child_count": 4,
      "reference_id": "MONDO:0008346"
    },
    {
      "id": 16157,
      "label": "chronic beryllium disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:10322",
          "EFO:0007168",
          "GARD:0000867",
          "ICD9:503",
          "MEDGEN:67440",
          "MESH:D001607",
          "MedDRA:10004485",
          "Orphanet:133",
          "SCTID:18121009",
          "UMLS:C0221052",
          "icd11.foundation:212013370"
        ],
        "synonyms": [
          "berylliosis",
          "chronic berylliosis",
          "chronic beryllium lung disease",
          "Beryllliosis",
          "Subacute berylliosis",
          "acute berylliosis",
          "beryllium disease",
          "chronic pulmonary berylliosis",
          "reversible berylliosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "Chronic beryllium disease (CBD) is a granulomatous, interstitial lung disease that occurs in individuals who develop beryllium sensitization (BeS), a cell-mediated immune response to environmental and occupational beryllium exposure. BeS precedes the lung disease that may present with chronic dry cough, fatigue, weight loss, chest pain, and increasing dyspnea."
      },
      "child_count": 0,
      "reference_id": "MONDO:0015274"
    },
    {
      "id": 16976,
      "label": "asbestosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:2596-4484",
          "DOID:10320",
          "EFO:0007153",
          "GARD:0005852",
          "ICD9:501",
          "MEDGEN:2462",
          "MESH:D001195",
          "NCIT:C84573",
          "Orphanet:2302",
          "SCTID:22607003",
          "UMLS:C0003949",
          "icd11.foundation:898495881"
        ],
        "synonyms": [
          "asbestos dust pneumoconiosis",
          "asbestos pneumoconiosis",
          "asbestosis",
          "pneumoconiosis from asbestos dust",
          "asbestos intoxication",
          "idiopathic interstitial pneumonitis - from asbestos exposure",
          "pulmonary fibrosis - from asbestos exposure"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ],
        "definition": "A lung disorder caused by inhalation of asbestos fibers. It results in fibrosis of the lung parenchyma. Signs and symptoms include coughing, shortness of breath and chest pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016466"
    },
    {
      "id": 20961,
      "label": "mixed dust pneumoconiosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008374",
          "ICD9:504",
          "MEDGEN:78109",
          "SCTID:32139003",
          "UMLS:C0264436"
        ],
        "synonyms": [
          "mixed dust pneumoconiosis",
          "Mixed dust pneumoconiosis",
          "labrador lung"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0022745"
    },
    {
      "id": 21207,
      "label": "graphite pneumoconiosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4804,
        16616
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0008359",
          "ICD9:503",
          "MEDGEN:120502",
          "SCTID:17385007",
          "UMLS:C0264439"
        ],
        "synonyms": [
          "graphite fibrosis of lung",
          "graphite pneumoconiosis",
          "carbon pneumoconiosis",
          "graphite fibrosis",
          "graphite lung disease",
          "graphitosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005087",
            "name": "respiratory system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0023286"
    }
  ],
  "roots": [
    {
      "id": 16615,
      "label": "interstitial lung disease"
    }
  ]
}