{
  "id": 16658,
  "label": "toluene embryopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016016",
  "properties": {
    "xrefs": [
      "GARD:0018751",
      "MEDGEN:444131",
      "MESH:C538114",
      "Orphanet:1920",
      "UMLS:C2931737",
      "icd11.foundation:1446076607"
    ],
    "synonyms": [
      "toluene embryopathy",
      "Hersh Podruch Weisskopk syndrome",
      "microcephaly, central nervous system dysfunction, minor craniofacial and limb anomalies, and variable growth deficiency"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Toluene embryopathy is a neurodevelopmental teratologic syndrome due to prenatal exposure to toluene. The disease is characterized by prematurity, low birth weight, dysmorphic features (short palpebral fissures, deep set eyes, low set ears, mid-facial hypoplasia, flat nasal bridge, thin upper lip, micrognathia, spatulate fingertips and small fingernails), central nervous system dysfunctions (intellectual disability, microcephaly, language impairment, hyperactivity, visual dysfunction) and postnatal growth delay. Prenatal exposure to toluene occurs as a result of incidental occupational exposure or solvent abuse during pregnancy. The features of toluene embryopathy often overlap with those seen in fetal alcohol syndrome."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17143,
      "label": "toxic or drug-related embryofetopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19507
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:1843068",
          "MESH:D000014",
          "Orphanet:251529",
          "UMLS:C5680710",
          "icd11.foundation:293076727"
        ],
        "definition": "Congenital abnormalities caused by medicinal substances or drugs of abuse given to or taken by the mother, or to which she is inadvertently exposed during the manufacture of such substances. The concept excludes abnormalities resulting from exposure to non-medicinal chemicals in the environment."
      },
      "child_count": 22,
      "reference_id": "MONDO:0016677"
    },
    {
      "id": 24488,
      "label": "neurodevelopmental disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0010642",
          "MEDGEN:453059",
          "MESH:D065886",
          "MedDRA:10064062",
          "NCIT:C89338",
          "SCTID:700364009",
          "UMLS:C1535926"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A behavioral and cognitive disorder with onset during the developmental period that involves impaired or aberrant development of intellectual, motor, or social functions."
      },
      "child_count": 18,
      "reference_id": "MONDO:0700092"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17143,
      "label": "toxic or drug-related embryofetopathy"
    },
    {
      "id": 24488,
      "label": "neurodevelopmental disorder"
    }
  ]
}