{
  "id": 16666,
  "label": "erythromelalgia",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016028",
  "properties": {
    "xrefs": [
      "DOID:9240",
      "ICD10CM:I73.81",
      "ICD9:443.82",
      "MEDGEN:8687",
      "MESH:D004916",
      "MedDRA:10015284",
      "NCIT:C34593",
      "Orphanet:1956",
      "SCTID:37151006",
      "UMLS:C0014804",
      "icd11.foundation:838760425"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ],
    "definition": "A rare neurovascular peripheral pain disorder due to the intermittent blockage of the blood vessels, usually in the lower extremities or hands. This causes hyperemia and inflammation at the origin of burning pain and skin redness. The attacks are periodic and are commonly triggered by heat, pressure, mild activity, exertion, insomnia or stress. Erythromelalgia may occur either as a primary or secondary disorder. Primary erythromelalgia is caused by gene mutations. Secondary erythromelalgia can result from small fiber peripheral neuropathy of any cause, essential thrombocytemia, hypercholesterolemia, mushroom or mercury poisoning, and some autoimmune disorders."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 6988,
      "label": "peripheral vascular disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:341",
          "EFO:0003875",
          "ICD9:443.81",
          "MEDGEN:38790",
          "MESH:D016491",
          "NCIT:C35136",
          "UMLS:C0085096",
          "icd11.foundation:426429380"
        ],
        "synonyms": [
          "disease, peripheral vascular",
          "peripheral vascular disorder",
          "vascular disease, peripheral"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Any disorder affecting blood flow through the veins or arteries outside of the heart."
      },
      "child_count": 11,
      "reference_id": "MONDO:0005294"
    }
  ],
  "children": [
    {
      "id": 8949,
      "label": "primary erythermalgia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006377",
          "MEDGEN:8688",
          "NCIT:C125383",
          "OMIM:133020",
          "Orphanet:90026",
          "UMLS:C0014805",
          "icd11.foundation:327001486"
        ],
        "synonyms": [
          "PERYTHM",
          "primary erythromelalgia",
          "Mitchell disease (formerly)",
          "erythermalgia, primary",
          "erythromelalgia, familial",
          "erythromelalgia, primary",
          "neuropathy, small fiber",
          "neuropathy, small fibre",
          "small fiber neuropathy",
          "small fibre neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Primary erythermalgia is characterized by intermittent attacks of red, warm, painful burning extremities. It spontaneously arises during early childhood and adolescence in the absence of any detectable underlying disorder."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007571"
    },
    {
      "id": 22805,
      "label": "secondary erythromelalgia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16666
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022201",
          "ICD10CM:I73.8",
          "MEDGEN:639378",
          "Orphanet:529864",
          "UMLS:C0543820",
          "icd11.foundation:1009405597"
        ],
        "synonyms": [
          "Secondary erythermalgia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0035149"
    }
  ],
  "roots": [
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 6988,
      "label": "peripheral vascular disease"
    }
  ]
}