{
  "id": 16668,
  "label": "Evans syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016030",
  "properties": {
    "xrefs": [
      "DOID:8931",
      "GARD:0006389",
      "ICD10CM:D69.41",
      "ICD9:287.32",
      "MEDGEN:75773",
      "MESH:C536380",
      "MedDRA:10053873",
      "NANDO:1200310",
      "NCIT:C61284",
      "NORD:1112",
      "Orphanet:1959",
      "SCTID:75331009",
      "UMLS:C0272126",
      "icd11.foundation:1048228553"
    ],
    "synonyms": [
      "Evans' syndrome",
      "autoimmune hemolytic anaemia and autoimmune thrombocytopenia",
      "autoimmune hemolytic anemia and autoimmune thrombocytopenia",
      "immune pancytopenia",
      "Evan syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Evans syndrome is a rare chronic hematologic disorder characterized by the simultaneous or sequential association of autoimmune hemolytic anemia (AIHA; a disorder in which auto-antibodies are directed against red blood cells causing anemia of varying degrees of severity) with immune thrombocytopenic purpura (ITP; a coagulation disorder in which auto-antibodies are directed against platelets causing hemorrhagic episodes) and occasionally autoimmune neutropenia, in the absence of a known underlying etiology."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    },
    {
      "id": 6463,
      "label": "primary thrombocytopenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3016
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8925",
          "GARD:0024085",
          "ICD9:287.3",
          "ICD9:287.30",
          "ICD9:287.39",
          "MEDGEN:675208",
          "SCTID:267534000",
          "UMLS:C0701157"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ]
      },
      "child_count": 2,
      "reference_id": "MONDO:0004680"
    },
    {
      "id": 18985,
      "label": "autoimmune thrombocytopenia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4196,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018906",
          "MEDGEN:116621",
          "MedDRA:10050245",
          "Orphanet:71203",
          "SCTID:128091003",
          "UMLS:C0242584"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "An autoimmune form of thrombocytopenia."
      },
      "child_count": 4,
      "reference_id": "MONDO:0019098"
    },
    {
      "id": 19736,
      "label": "autoimmune hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3016,
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:0427-1178",
          "DOID:718",
          "EFO:1001264",
          "GARD:0005870",
          "ICD9:283.0",
          "MEDGEN:1918",
          "MESH:D000744",
          "MedDRA:10002046",
          "NANDO:1200305",
          "NANDO:2100181",
          "NCIT:C34378",
          "NORD:774",
          "OMIM:205700",
          "Orphanet:98375",
          "SCTID:413603009",
          "UMLS:C0002880",
          "icd11.foundation:1834341306"
        ],
        "synonyms": [
          "AHA",
          "AIHA",
          "Anemia, Hemolytic, Acquired Autoimmune",
          "autoimmune haemolytic anemia",
          "autoimmune hemolytic anemia",
          "acquired autoimmune hemolytic anaemia",
          "acquired autoimmune hemolytic anemia",
          "anaemia hemolytic autoimmune",
          "anemia hemolytic autoimmune",
          "anemia, autoimmune hemolytic",
          "familial auto-immune hemolytic anaemia (subtype)",
          "familial auto-immune hemolytic anemia (subtype)",
          "idiopathic autoimmune hemolytic anaemia",
          "idiopathic autoimmune hemolytic anemia",
          "immuno-hemolytic anaemia",
          "immuno-hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia."
      },
      "child_count": 14,
      "reference_id": "MONDO:0020108"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4370,
      "label": "syndromic disease"
    },
    {
      "id": 6463,
      "label": "primary thrombocytopenia"
    },
    {
      "id": 18985,
      "label": "autoimmune thrombocytopenia"
    },
    {
      "id": 19736,
      "label": "autoimmune hemolytic anemia"
    }
  ]
}