{
  "id": 16676,
  "label": "harlequin syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016040",
  "properties": {
    "xrefs": [
      "GARD:0008610",
      "ICD9:705.89",
      "MEDGEN:384475",
      "MESH:C535634",
      "Orphanet:199282",
      "SCTID:14070001000004105",
      "UMLS:C2029348"
    ],
    "synonyms": [
      "progressive isolated segmental anhidrosis",
      "sudden onset of unilateral flushing and sweating",
      "unilateral loss of facial flushing and sweating with contralateral anhidrosis"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Harlequin syndrome (HSD) is an autonomic disorder occurring at any age and characterized by unilateral flushing and sweating, involving the face and sometimes arm and chest, in condition of thermal, exercise or emotional stress without sympathetic ocular manifestations. However, tonic pupils, parasympathetic oculomotor lesion and pre- or postganglionic sudomotor sympathetic deficit can rarely occur."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3525,
      "label": "autonomic nervous system disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4657,
        5512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:11465",
          "EFO:0009532",
          "ICD9:337.1",
          "ICD9:337.9",
          "MEDGEN:218837",
          "MESH:D001342",
          "SCTID:128123007",
          "SCTID:15241006",
          "UMLS:C1145628",
          "icd11.foundation:1397803237"
        ],
        "synonyms": [
          "autonomic nervous disease",
          "autonomic nervous system disease",
          "autonomic nervous system disease or disorder",
          "disease of autonomic nervous system",
          "disease or disorder of autonomic nervous system",
          "disorder of autonomic nervous system",
          "disorder of peripheral autonomic nervous system",
          "disorder of the autonomic nervous system",
          "autonomic peripheral nervous system diseases",
          "dysautonomia",
          "peripheral autonomic nervous system diseases",
          "ANS (autonomic nervous system) diseases",
          "ANS disease",
          "ANS diseases",
          "autonomic central nervous system diseases",
          "autonomic disease",
          "autonomic diseases",
          "autonomic dysfunction, segmental",
          "autonomic dysfunctions, segmental",
          "autonomic nervous system disorders",
          "central autonomic nervous system diseases",
          "disorders of the autonomic nervous system",
          "nervous system diseases, autonomic",
          "nervous system diseases, sympathetic",
          "segmental autonomic dysfunction",
          "segmental autonomic dysfunctions"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disease involving the autonomic nervous system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0001292"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3525,
      "label": "autonomic nervous system disorder"
    }
  ]
}