{
  "id": 16678,
  "label": "late-onset isolated ACTH deficiency",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016042",
  "properties": {
    "xrefs": [
      "GARD:0020331",
      "MEDGEN:1651973",
      "Orphanet:199299",
      "UMLS:C4751433",
      "icd11.foundation:1651831896"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Late-onset isolated ACTH deficiency is a rare, acquired, pituitary hormone deficiency characterized by secondary adrenal insufficiency, with normal secretion of anterior pituitary hormones, except for ACTH. Patients present with weakness, fatigue, weight loss, anorexia, vomiting/nausea, hypoglycemia, and abnormally low serum ACTH and cortisol levels. Association with autoimmune disease such as Hashimoto's thyroiditis has been described."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19567,
      "label": "acquired pituitary hormone deficiency",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6876,
        16072
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019278",
          "MEDGEN:1843262",
          "NANDO:2200313",
          "Orphanet:95502",
          "UMLS:C5681569"
        ],
        "synonyms": [
          "acquired hypopituitarism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of hypopituitarism that is acquired during the lifetime of the individual."
      },
      "child_count": 8,
      "reference_id": "MONDO:0019832"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19567,
      "label": "acquired pituitary hormone deficiency"
    }
  ]
}