{
  "id": 16680,
  "label": "cleft lip/palate",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016044",
  "properties": {
    "xrefs": [
      "GARD:0017092",
      "ICD10CM:Q35-Q37",
      "ICD9:749.20",
      "ICD9:749.25",
      "MEDGEN:57640",
      "MedDRA:10009260",
      "Orphanet:199306",
      "SCTID:66948001",
      "UMLS:C0158646"
    ],
    "synonyms": [
      "FLP",
      "alveolar cleft lip and palate",
      "cleft lip and palate",
      "cleft lip-alveolus-palate syndrome"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      }
    ],
    "definition": "Cleft lip and palate is a fissure type embryopathy extending across the upper lip, nasal base, alveolar ridge and the hard and soft palate."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 2863,
      "label": "orofacial cleft",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5714,
        21213
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050567",
          "MEDGEN:472000",
          "OMIMPS:119530",
          "SCTID:449790007",
          "UMLS:C3266076"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "A disorder of facial skeleton that is characterized by cleft lip and/or cleft palate that result in feeding, speech and hearing problems caused by failures during development."
      },
      "child_count": 32,
      "reference_id": "MONDO:0000358"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 12039,
      "label": "orofacial cleft 11",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080404",
          "GARD:0018303",
          "MEDGEN:436944",
          "OMIM:600625",
          "UMLS:C2677434"
        ],
        "synonyms": [
          "BMP4 orofacial cleft",
          "orofacial cleft 11",
          "orofacial cleft caused by mutation in BMP4",
          "orofacial cleft type 11",
          "OFC11",
          "cleft Lip, congenital Healed",
          "cleft lip with or without cleft palate, nonsyndromic, 11",
          "congenital Healed cleft lip"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any orofacial cleft in which the cause of the disease is a mutation in the BMP4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0010906"
    },
    {
      "id": 13206,
      "label": "orofacial cleft 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16269,
        16679,
        16680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080399",
          "GARD:0018305",
          "MEDGEN:373280",
          "MESH:C563843",
          "OMIM:608874",
          "UMLS:C1837210"
        ],
        "synonyms": [
          "MSX1 orofacial cleft",
          "orofacial cleft 5",
          "orofacial cleft caused by mutation in MSX1",
          "orofacial cleft type 5",
          "OFC5",
          "cleft lip with or without cleft palate, nonsyndromic, 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any orofacial cleft in which the cause of the disease is a mutation in the MSX1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0012142"
    },
    {
      "id": 14411,
      "label": "orofacial cleft 10",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080403",
          "GARD:0018306",
          "MEDGEN:355621",
          "MESH:C566605",
          "OMIM:613705",
          "UMLS:C1866070"
        ],
        "synonyms": [
          "SUMO1 orofacial cleft",
          "orofacial cleft 10",
          "orofacial cleft 10, isolated cases",
          "orofacial cleft caused by mutation in SUMO1",
          "orofacial cleft type 10",
          "OFC10",
          "cleft lip with or without cleft palate, nonsyndromic, 10"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any orofacial cleft in which the cause of the disease is a mutation in the SUMO1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0013378"
    },
    {
      "id": 15761,
      "label": "orofacial cleft 15",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16680
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080408",
          "GARD:0018307",
          "MEDGEN:909661",
          "OMIM:616788",
          "UMLS:C4225209"
        ],
        "synonyms": [
          "DLX4 cleft lip/palate",
          "OFC15",
          "cleft lip/palate caused by mutation in DLX4",
          "orofacial cleft 15",
          "orofacial cleft type 15"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          }
        ],
        "definition": "Any cleft lip/palate in which the cause of the disease is a mutation in the DLX4 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0014772"
    }
  ],
  "roots": [
    {
      "id": 2863,
      "label": "orofacial cleft"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}