{
  "id": 16702,
  "label": "hereditary gingival fibromatosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016070",
  "properties": {
    "xrefs": [
      "DOID:0060466",
      "GARD:0016582",
      "MEDGEN:140775",
      "OMIMPS:135300",
      "Orphanet:2024",
      "SCTID:109620006",
      "UMLS:C0399440",
      "icd11.foundation:1911315646"
    ],
    "synonyms": [
      "autosomal dominant gingival fibromatosis",
      "autosomal dominant gingival hyperplasia",
      "hereditary gingival fibromatosis",
      "hereditary gingival hyperplasia"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0006858",
        "name": "mouth disorder"
      }
    ],
    "definition": "Hereditary gingival fibromatosis (HGF) is a rare benign, slowly progressive, non-inflammatory fibrous hyperplasia of the maxillary and mandibular gingivae that generally occurs with the eruption of the permanent (or more rarely the primary) dentition or even at birth. It presents as a localized or generalized, smooth or nodular overgrowth of the gingival tissues of varying severity. It can be isolated, with autosomal dominant inheritance, or as part of a syndrome."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 6,
  "parents": [
    {
      "id": 4579,
      "label": "gingival overgrowth",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4170
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3086",
          "ICD10CM:K06.1",
          "ICD9:523.8",
          "MEDGEN:87712",
          "MESH:D019214",
          "SCTID:54711002",
          "UMLS:C0376480"
        ],
        "synonyms": [
          "gingival enlargement"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Excessive growth of the gingiva either by an increase in the size of the constituent cells (gingival hypertrophy) or by an increase in their number (gingival hyperplasia). (From Jablonski's Dictionary of Dentistry, 1992, p574)"
      },
      "child_count": 3,
      "reference_id": "MONDO:0002507"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "ICD10CM:Q00-Q99",
          "MEDGEN:1843482",
          "UMLS:C0694457"
        ],
        "definition": "Any disease or disorder that disrupts the process development of an anatomical structure. Can be due to genetic or environmental causes. Typically happens during embryogenesis, but also includes post-embryonic development."
      },
      "child_count": 190,
      "reference_id": "MONDO:0021147"
    }
  ],
  "children": [
    {
      "id": 8977,
      "label": "fibromatosis, gingival, 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006509",
          "MEDGEN:1647111",
          "OMIM:135300",
          "UMLS:C4551558"
        ],
        "synonyms": [
          "SOS1 gingival fibromatosis",
          "SOS1 hereditary gingival fibromatosis",
          "fibromatosis, gingival, 1",
          "fibromatosis, gingival, type 1",
          "gingival fibromatosis caused by mutation in SOS1",
          "hereditary gingival fibromatosis caused by mutation in SOS1",
          "GGF1",
          "GINGF",
          "GINGF1",
          "HGF1",
          "fibromatosis gingival, hereditary, 1",
          "fibromatosis, gingival, hereditary",
          "gingival fibromatosis, 1",
          "hereditary gingival fibromatosis, 1"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ],
        "definition": "Any gingival fibromatosis in which the cause of the disease is a mutation in the SOS1 gene."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007609"
    },
    {
      "id": 12659,
      "label": "fibromatosis, gingival, 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002474",
          "MEDGEN:344226",
          "MESH:C565323",
          "OMIM:605544",
          "UMLS:C1854181"
        ],
        "synonyms": [
          "GINGF2",
          "fibromatosis, gingival, 2",
          "GGF2",
          "HGF2",
          "fibromatosis gingival, hereditary, 2",
          "fibromatosis, gingival, hereditary, 2",
          "gingival fibromatosis, 2",
          "hereditary gingival fibromatosis, 2"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0011563"
    },
    {
      "id": 13429,
      "label": "fibromatosis, gingival, 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0009911",
          "MEDGEN:351261",
          "MESH:C537928",
          "OMIM:609955",
          "UMLS:C1864960"
        ],
        "synonyms": [
          "GINGF3",
          "fibromatosis, gingival, 3",
          "GGF3",
          "HGF3",
          "fibromatosis gingival, hereditary, 3",
          "fibromatosis, gingival, hereditary, 3",
          "gingival fibromatosis, 3",
          "hereditary gingival fibromatosis, 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012378"
    },
    {
      "id": 13645,
      "label": "fibromatosis, gingival, 4",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002475",
          "MEDGEN:370209",
          "MESH:C567028",
          "OMIM:611010",
          "UMLS:C1970245"
        ],
        "synonyms": [
          "GINGF4",
          "fibromatosis, gingival, 4",
          "GGF4",
          "HGF4",
          "fibromatosis gingival, hereditary, 4",
          "fibromatosis, gingival, hereditary, 4",
          "gingival fibromatosis, 4",
          "hereditary gingival fibromatosis, 4"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0012598"
    },
    {
      "id": 22665,
      "label": "fibromatosis, gingival, 5",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080280",
          "GARD:0018357",
          "MEDGEN:1624392",
          "OMIM:617626",
          "UMLS:C4539942"
        ],
        "synonyms": [
          "fibromatosis, gingival, 5",
          "GGF5",
          "GINGF5",
          "fibromatosis, gingival, hereditary, 5",
          "gingival fibromatosis 5"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0033493"
    },
    {
      "id": 26131,
      "label": "fibromatosis, gingival, 6",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16702
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0027331",
          "MEDGEN:1875031",
          "OMIM:620999",
          "UMLS:C5975501"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0006858",
            "name": "mouth disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0975841"
    }
  ],
  "roots": [
    {
      "id": 4579,
      "label": "gingival overgrowth"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    },
    {
      "id": 20383,
      "label": "disorder of development or morphogenesis"
    }
  ]
}