{
  "id": 16723,
  "label": "malignant non-dysgerminomatous germ cell tumor of ovary",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016096",
  "properties": {
    "xrefs": [
      "GARD:0020349",
      "MEDGEN:1826164",
      "NCIT:C102870",
      "Orphanet:206538",
      "UMLS:C5679783"
    ],
    "synonyms": [
      "non-dysgerminomatous germ cell cancer of ovary",
      "ovarian Nondysgerminomatous germ cell tumor",
      "ovarian Nondysgerminomatous germ cell tumour",
      "ovarian non-dysgerminomatous germ cell tumor",
      "ovarian non-dysgerminomatous germ cell tumour"
    ],
    "categories": [
      {
        "ref": "MONDO:0005039",
        "name": "reproductive system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor other than dysgerminoma that arises from the ovary."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 5339,
      "label": "ovarian primitive germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18315
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5351",
          "GARD:0023506",
          "MEDGEN:275291",
          "NCIT:C39986",
          "UMLS:C1518727"
        ],
        "synonyms": [
          "ovarian primitive germ cell tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant tumor that arises from the ovary and is characterized by the presence of malignant germ cell components but lacks a teratoma component."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003408"
    },
    {
      "id": 20708,
      "label": "nongerminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0010165",
          "MEDGEN:220426",
          "NCIT:C121619",
          "ONCOTREE:NSGCT",
          "UMLS:C1266158"
        ],
        "synonyms": [
          "Nongerminomatous germ cell tumor",
          "Nongerminomatous germ cell tumor Including central nervous system",
          "Nongerminomatous germ cell tumour",
          "Nongerminomatous germ cell tumour Including central nervous system",
          "non-dysgerminomatous germ cell tumor",
          "non-dysgerminomatous germ cell tumour",
          "non-germinomatous germ cell tumor",
          "non-germinomatous germ cell tumour",
          "non-seminomatous germ cell tumor",
          "non-seminomatous germ cell tumour",
          "NSGCT"
        ],
        "definition": "A term that refers to teratoma, embryonal carcinoma, yolk sac tumor, choriocarcinoma, or mixed forms of these tumors."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021656"
    }
  ],
  "children": [
    {
      "id": 5477,
      "label": "ovarian embryonal carcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7107,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5681",
          "EFO:1000415",
          "GARD:0023568",
          "MEDGEN:91090",
          "NCIT:C8108",
          "ONCOTREE:OEC",
          "SCTID:254872007",
          "UMLS:C0346183"
        ],
        "synonyms": [
          "embryonal carcinoma of ovary",
          "embryonal carcinoma of the ovary",
          "ovarian embryonal carcinoma",
          "ovary embryonal carcinoma",
          "embryonal carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An embryonal carcinoma arising from the ovary. Signs and symptoms include the presence of an abdominal mass and abdominal pain."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003581"
    },
    {
      "id": 5842,
      "label": "polyembryoma of the ovary",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16595,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6774",
          "GARD:0023764",
          "MEDGEN:271323",
          "NCIT:C39990",
          "ONCOTREE:OPE",
          "UMLS:C1514199"
        ],
        "synonyms": [
          "ovarian polyembryoma",
          "polyembryoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare, malignant germ cell tumor arising from the ovary. It is characterized by the presence of embryoid bodies which resemble early embryos."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003989"
    },
    {
      "id": 6111,
      "label": "gestational ovarian choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5421,
        16723,
        19993
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7591",
          "GARD:0023917",
          "MEDGEN:274586",
          "NCIT:C40442",
          "UMLS:C1517538"
        ],
        "synonyms": [
          "gestational ovarian choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A rare malignant trophoblastic tumor that arises from the ovary as a result of ectopic ovarian pregnancy. There is no germ cell component present."
      },
      "child_count": 0,
      "reference_id": "MONDO:0004294"
    },
    {
      "id": 7870,
      "label": "ovarian yolk sac tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7365,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5350",
          "EFO:1000437",
          "GARD:0024374",
          "MEDGEN:83415",
          "NCIT:C8107",
          "ONCOTREE:OYST",
          "SCTID:254876005",
          "UMLS:C0346188"
        ],
        "synonyms": [
          "endodermal sinus neoplasm of ovary",
          "endodermal sinus neoplasm of the ovary",
          "endodermal sinus tumor of ovary",
          "endodermal sinus tumor of the ovary",
          "endodermal sinus tumour of the ovary",
          "germ cell endodermal sinus neoplasm of ovary",
          "germ cell endodermal sinus neoplasm of the ovary",
          "germ cell endodermal sinus tumor of ovary",
          "germ cell endodermal sinus tumor of the ovary",
          "germ cell endodermal sinus tumour of ovary",
          "germ cell endodermal sinus tumour of the ovary",
          "ovarian endodermal sinus neoplasm",
          "ovarian endodermal sinus tumor",
          "ovarian germ cell endodermal sinus neoplasm",
          "ovarian germ cell endodermal sinus tumor",
          "ovarian germ cell endodermal sinus tumour",
          "ovarian yolk Sac neoplasm",
          "ovarian yolk sac tumor",
          "ovary yolk sac tumor",
          "ovary yolk sac tumour",
          "yolk Sac neoplasm of ovary",
          "yolk Sac neoplasm of the ovary",
          "yolk Sac tumor of ovary",
          "yolk Sac tumor of the ovary",
          "yolk Sac tumour of ovary",
          "yolk Sac tumour of the ovary",
          "yolk sac tumor",
          "yolk sac tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A usually rapidly growing malignant germ cell tumor arising from the ovary. It usually occurs in children and adolescents. Signs and symptoms include abdominal pain and a large abdominal or pelvic mass. The serum alpha-fetoprotein is almost always elevated preoperatively. Morphologically, there is marked heterogeneity due to numerous patterns of differentiation coexisting in the same tumor. The most common pattern is reticular."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006344"
    },
    {
      "id": 18450,
      "label": "immature ovarian teratoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5427,
        5691,
        16723
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6331",
          "GARD:0021654",
          "MEDGEN:138044",
          "NCIT:C39995",
          "NCIT:C8111",
          "ONCOTREE:OIMT",
          "Orphanet:398987",
          "SCTID:254871000",
          "UMLS:C0346182",
          "icd11.foundation:551209361"
        ],
        "synonyms": [
          "immature germ cell teratoma of ovary",
          "immature germ cell teratoma of the ovary",
          "immature ovarian teratoma",
          "immature teratoma of ovary",
          "immature teratoma of the ovary",
          "malignant germ cell teratoma of ovary",
          "malignant germ cell teratoma of the ovary",
          "malignant ovarian germ cell teratoma",
          "malignant ovarian teratoma",
          "malignant teratoma of ovary",
          "malignant teratoma of the ovary",
          "ovarian germ cell immature teratoma",
          "ovarian immature germ cell teratoma",
          "ovarian immature teratoma",
          "ovarian malignant teratoma",
          "ovary malignant teratoma",
          "immature teratoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A malignant germ cell tumor arising from the ovary. It usually affects females in their first two decades of life. It contains variable amounts of immature embryonal tissues. Based on the amount of immature neuroepithelial component, immature teratomas are graded from 1 to 3. The stage and grade of the tumor and the grade of the metastatic tumor are the important factors that predict prognosis. The use of cisplatin-based combination chemotherapy has significantly improved the survival rates of the patients."
      },
      "child_count": 6,
      "reference_id": "MONDO:0018369"
    }
  ],
  "roots": [
    {
      "id": 5339,
      "label": "ovarian primitive germ cell tumor"
    },
    {
      "id": 20708,
      "label": "nongerminomatous germ cell tumor"
    }
  ]
}