{
  "id": 16765,
  "label": "hereditary hyperparathyroidism",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016166",
  "properties": {
    "xrefs": [
      "GARD:0020408",
      "MEDGEN:1843372",
      "OMIMPS:145000",
      "Orphanet:208596",
      "UMLS:C5680826"
    ],
    "synonyms": [
      "genetic hyperparathyroidism"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An instance of hyperparathyroidism that is caused by an inherited genomic modification in an individual."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 3927,
      "label": "hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3463
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13543",
          "EFO:0008506",
          "ICD9:252.0",
          "ICD9:252.00",
          "MEDGEN:6967",
          "MESH:D006961",
          "NANDO:2100123",
          "NANDO:2200343",
          "NCIT:C48259",
          "SCTID:66999008",
          "UMLS:C0020502",
          "icd11.foundation:9633776"
        ],
        "synonyms": [
          "hyperparathyroidism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Hyperfunction of the parathyroid glands resulting in the overproduction of parathyroid hormone. It may be primary or secondary; primary hyperparathyroidism is caused by parathyroid adenoma, parathyroid hyperplasia, parathyroid carcinoma, and multiple endocrine neoplasia. It is associated with hypercalcemia and hypophosphatemia. Signs and symptoms include weakness, fatigue, nausea, vomiting, constipation, depression, bone pain, osteoporosis, cystic bone lesions, and kidney stones. Secondary hyperparathyroidism is caused by the chronic stimulation of the parathyroid glands in patients with chronic renal failure, rickets, and malabsorption syndromes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001741"
    },
    {
      "id": 5714,
      "label": "hereditary disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29382
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:630",
          "EFO:0000508",
          "ICD9:799.89",
          "MEDGEN:5527",
          "MESH:D030342",
          "NCIT:C3101",
          "SCTID:32895009",
          "UMLS:C0019247"
        ],
        "synonyms": [
          "genetic condition",
          "genetic disease",
          "genetic disorder",
          "hereditary disease",
          "hereditary disease or disorder",
          "hereditary diseases",
          "inherited disease",
          "inherited genetic disease",
          "molecular disease",
          "Mendelian disease",
          "familial disorder",
          "inborn disorder"
        ],
        "definition": "A disease that is caused by genetic modifications where those modifications are inherited from a parent's genome."
      },
      "child_count": 1925,
      "reference_id": "MONDO:0003847"
    }
  ],
  "children": [
    {
      "id": 16897,
      "label": "familial primary hyperparathyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        11973,
        16765,
        20525
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002837",
          "MEDGEN:543605",
          "Orphanet:2207",
          "UMLS:C0271846",
          "icd11.foundation:1186866066"
        ],
        "synonyms": [
          "hereditary primary hyperparathyroidism (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An instance of primary hyperparathyroidism (disease) that is caused by an inherited modification of the individual's genome."
      },
      "child_count": 15,
      "reference_id": "MONDO:0016365"
    },
    {
      "id": 22278,
      "label": "hyperparathyroidism, transient neonatal",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16765,
        24807
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016304",
          "MEDGEN:722059",
          "OMIM:618188",
          "UMLS:C1300287"
        ],
        "synonyms": [
          "HRPTTN",
          "hyperparathyroidism, transient neonatal"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0032591"
    }
  ],
  "roots": [
    {
      "id": 3927,
      "label": "hyperparathyroidism"
    },
    {
      "id": 5714,
      "label": "hereditary disease"
    }
  ]
}