{
  "id": 16801,
  "label": "Guillain-Barre syndrome",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016218",
  "properties": {
    "xrefs": [
      "DOID:12842",
      "EFO:0007292",
      "GARD:0006554",
      "ICD10CM:G61.0",
      "MEDGEN:5399",
      "MESH:D020275",
      "MedDRA:10018767",
      "NCIT:C116345",
      "Orphanet:2103",
      "SCTID:40956001",
      "UMLS:C0018378"
    ],
    "synonyms": [
      "GBS",
      "Guillain Barre syndrome",
      "Guillain Barré syndrome",
      "Guillain-Barre-Strohl syndrome",
      "Guillain-Barré syndrome",
      "Guillain-Barré-Strohl syndrome",
      "post-infectious polyneuritis",
      "post-infective polyneuritis",
      "postinfectious polyneuritis",
      "Landry's ascending paralysis",
      "Landry-Guillain-Barre-Strohl syndrome",
      "acute autoimmune peripheral neuropathy",
      "acute immune-mediated polyneuropathy",
      "acute inflammatory demyelinating polyneuropathy",
      "acute inflammatory neuropathy"
    ],
    "categories": [
      {
        "ref": "MONDO:0002254",
        "name": "syndromic disease"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A spectrum of rare post-infectious neuropathies that usually occur in otherwise healthy patients. GBS is clinically heterogeneous and encompasses acute inflammatory demyelinating polyradiculoneuropathy (AIDP), acute motor axonal neuropathy (AMAN) and acute motor-sensory axonal neuropathy (AMSAN), Miller-Fisher syndrome (MFS) and some other regional variants."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 11,
  "parents": [
    {
      "id": 3006,
      "label": "autoimmune disorder of peripheral nervous system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4981,
        5512
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060033"
        ],
        "synonyms": [
          "peripheral nervous system autoimmune disease",
          "peripheral nervous system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the peripheral nervous system."
      },
      "child_count": 8,
      "reference_id": "MONDO:0000590"
    },
    {
      "id": 4370,
      "label": "syndromic disease",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        29379
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:225",
          "MEDGEN:11688",
          "MESH:D013577",
          "NCIT:C28193",
          "OGMS:0000086",
          "UMLS:C0039082"
        ],
        "synonyms": [
          "cluster, symptom",
          "clusters, symptom",
          "symptom cluster",
          "symptom clusters",
          "syndrome",
          "syndrome associated with disease or disorder",
          "syndromes",
          "syndromic disease",
          "syndromic disease or disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          }
        ],
        "definition": "A group of signs, symptoms, and clinicopathological characteristics that may or may not have a genetic basis and collectively define an abnormal condition."
      },
      "child_count": 1182,
      "reference_id": "MONDO:0002254"
    }
  ],
  "children": [
    {
      "id": 9047,
      "label": "Guillain-Barre syndrome, familial",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0009538",
          "GARD:0018211",
          "MEDGEN:901636",
          "MedDRA:10057645",
          "NANDO:1200030",
          "NANDO:2100251",
          "NANDO:2200905",
          "OMIM:139393",
          "SCTID:716723000",
          "UMLS:C4083008"
        ],
        "synonyms": [
          "AIDP",
          "Guillain-Barre syndrome, familial",
          "neuropathy, inflammatory demyelinating",
          "polyneuropathy, inflammatory demyelinating, acute",
          "GBS"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A form of Guillain-Barre syndrome (GBS) that occurs in persons or families with a genetic predisposition to the acute or chronic forms of GBS. Note that GBS is considered to be a complex multifactorial disorder with both genetic and environmental factors, and families with clear Mendelian inheritance have been rarely reported: a mutation in the PMP22 gene (601097) on chromosome 17 was identified in a single family with the acute (AIDP) and chronic (CIDP) forms of inflammatory demyelinating polyneuropathy."
      },
      "child_count": 0,
      "reference_id": "MONDO:0007691"
    },
    {
      "id": 17001,
      "label": "pharyngeal-cervical-brachial variant of Guillain-Barre syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020614",
          "MEDGEN:1682775",
          "Orphanet:231426",
          "UMLS:C5190783"
        ],
        "synonyms": [
          "PCB variant of GBS",
          "PCB variant of Guillain-Barre syndrome",
          "PCB variant of Guillain-Barré syndrome",
          "pharyngeal-cervical-brachial weakness",
          "pharyngo-cervico-brachial variant of GBS",
          "pharyngo-cervico-brachial variant of Guillain-Barre syndrome",
          "pharyngo-cervico-brachial variant of Guillain-Barré syndrome",
          "pharyngeal-cervical-brachial variant of Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016496"
    },
    {
      "id": 17002,
      "label": "paraparetic variant of Guillain-Barre syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020615",
          "MEDGEN:1644763",
          "Orphanet:231445",
          "UMLS:C4707803"
        ],
        "synonyms": [
          "paraparetic variant of GBS",
          "paraparetic variant of Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Paraparetic variant of Guillain-Barré syndrome is a rare variant of Guillain-Barré syndrome characterized by isolated leg weakness, areflexia and radicular leg pain that may simulate a cauda equina or spinal cord syndrome. The arms, ocular, facial, and oropharyngeal muscles are spared, and sphincteric function is normal."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016497"
    },
    {
      "id": 17003,
      "label": "acute pure sensory neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020616",
          "MEDGEN:1682724",
          "Orphanet:231450",
          "UMLS:C5190881"
        ],
        "synonyms": [
          "acute pure sensory GBS",
          "acute pure sensory Guillain-Barre syndrome",
          "acute pure sensory Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016498"
    },
    {
      "id": 17004,
      "label": "autoimmune autonomic ganglionopathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020617",
          "MEDGEN:746161",
          "Orphanet:231457",
          "SCTID:430042004",
          "UMLS:C2315246"
        ],
        "synonyms": [
          "AAG",
          "acute panautonomic GBS",
          "acute panautonomic Guillain-Barre syndrome",
          "acute panautonomic Guillain-Barré syndrome",
          "acute panautonomic neuropathy",
          "acute pandysautonomia",
          "autoimmune autonomic neuropathy",
          "idiopathic subacute autonomic neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare variant of Guillain-Barré syndrome characterized by acute post-ganglionic sympathetic and parasympathetic failure presenting several weeks after acute infection with gastrointestinal symptoms (abdominal pain, vomiting, constipation, diarrhea, gastroparesis, ileus), orthostatic hypotension, erectile dysfunction, urinary frequency, urgency or retention, vasomotor instability with acrocyanosis and reduced salivation, lacrimation and sweating."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016499"
    },
    {
      "id": 17005,
      "label": "acute sensory ataxic neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020618",
          "MEDGEN:1641312",
          "Orphanet:231466",
          "SCTID:766049000",
          "UMLS:C4707661",
          "icd11.foundation:1951716831"
        ],
        "synonyms": [
          "ASAN",
          "acute sensory ataxic GBS",
          "acute sensory ataxic Guillain-Barre syndrome",
          "acute sensory ataxic Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute sensory ataxic neuropathy is a rare variant of Guillain-Barré syndrome characterized by acute onset monophasic sensory neuropathy with diminished or absent tendon reflexes, loss of proprioception, positive Romberg sign and nerve conduction features of demyelination. It presents several weeks after acute infection with paresthesias, ataxia and neuropathic pain."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016500"
    },
    {
      "id": 18761,
      "label": "facial diplegia with paresthesias",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021984",
          "MEDGEN:1798949",
          "Orphanet:480701",
          "UMLS:C5567526"
        ],
        "synonyms": [
          "facial diplegia with paresthesias variant of GBS",
          "facial diplegia with paresthesias variant of Guillain-Barre syndrome",
          "facial diplegia with paresthesias variant of Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018818"
    },
    {
      "id": 19810,
      "label": "acute inflammatory demyelinating polyradiculoneuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0016873",
          "MEDGEN:1648220",
          "NCIT:C116926",
          "Orphanet:98916",
          "UMLS:C4551910",
          "icd11.foundation:1196874419"
        ],
        "synonyms": [
          "AIDP",
          "GBS, acute inflammatory demyelinating polyradiculoneuropathic form",
          "Guillain-Barre syndrome, acute inflammatory demyelinating polyradiculoneuropathic form",
          "Guillain-Barré syndrome, acute inflammatory demyelinating polyradiculoneuropathic form",
          "acute idiopathic demyelinating polyneuropathy",
          "acute inflammatory demyelinating polyradiculopathy",
          "acute inflammatory polyneuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An inflammatory neuropathy belonging to the clinical spectrum of Guillain-Barre syndrome (GBS)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020347"
    },
    {
      "id": 19811,
      "label": "acute motor and sensory axonal neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019601",
          "MEDGEN:859705",
          "NCIT:C116927",
          "Orphanet:98917",
          "SCTID:716722005",
          "UMLS:C3900111"
        ],
        "synonyms": [
          "AMSAN",
          "acute motor-sensory axonal GBS",
          "acute motor-sensory axonal Guillain-Barre syndrome",
          "acute motor-sensory axonal Guillain-Barré syndrome",
          "acute motor-sensory axonal neuropathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute motor-sensory axonal neuropathy (AMSAN) is a motor-sensory, axonal form of Guillain-Barre syndrome (GBS)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020348"
    },
    {
      "id": 19812,
      "label": "acute motor axonal neuropathy",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801,
        20092
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019602",
          "MEDGEN:855842",
          "NCIT:C116929",
          "Orphanet:98918",
          "SCTID:715770009",
          "UMLS:C3890941",
          "icd11.foundation:745197078"
        ],
        "synonyms": [
          "AMAN",
          "acute pure motor GBS",
          "acute pure motor Guillain-Barre syndrome",
          "acute pure motor Guillain-Barré syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Acute motor axonal neuropathy (AMAN) is a pure motor axonal form of Guillain-Barre syndrome (GBS)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020349"
    },
    {
      "id": 23911,
      "label": "polyneuropathy, inflammatory demyelinating, chronic",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16801
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0026072"
        ],
        "synonyms": [
          "CIDP"
        ],
        "categories": [
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0100169"
    }
  ],
  "roots": [
    {
      "id": 3006,
      "label": "autoimmune disorder of peripheral nervous system"
    },
    {
      "id": 4370,
      "label": "syndromic disease"
    }
  ]
}