{
  "id": 16828,
  "label": "autoimmune hepatitis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016264",
  "properties": {
    "xrefs": [
      "DOID:2048",
      "EFO:0005676",
      "GARD:0005871",
      "ICD10CM:K75.4",
      "ICD9:571.42",
      "MEDGEN:1666753",
      "MESH:D019693",
      "MedDRA:10003827",
      "NANDO:1200441",
      "NANDO:1200442",
      "NANDO:2100264",
      "NCIT:C27029",
      "NORD:1897",
      "Orphanet:2137",
      "SCTID:408335007",
      "UMLS:C4721555",
      "icd11.foundation:1235727122"
    ],
    "synonyms": [
      "autoimmune liver disease",
      "autoimmune hepatitis",
      "autoimmune chronic active hepatitis",
      "autoimmune hepatitis with centrilobular necrosis",
      "chronic autoimmune hepatitis",
      "AIH",
      "autoimmune chronic hepatitis"
    ],
    "categories": [
      {
        "ref": "MONDO:0004335",
        "name": "digestive system disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Hepatitis caused by autoantibodies. Drugs, infections, and toxins may trigger the production of the autoantibodies against the liver parenchyma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6875,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060005",
          "ICD9:279.49",
          "MEDGEN:575099",
          "SCTID:237822008",
          "UMLS:C0342552"
        ],
        "synonyms": [
          "endocrine system autoimmune disease",
          "endocrine system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the endocrine system."
      },
      "child_count": 26,
      "reference_id": "MONDO:0000569"
    },
    {
      "id": 3002,
      "label": "autoimmune disorder of exocrine system",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060029"
        ],
        "synonyms": [
          "exocrine system autoimmune disease",
          "exocrine system hypersensitivity reaction type II disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the exocrine system."
      },
      "child_count": 3,
      "reference_id": "MONDO:0000586"
    },
    {
      "id": 3004,
      "label": "autoimmune disorder of gastrointestinal tract",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6151,
        8586
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060031"
        ],
        "synonyms": [
          "alimentary part of gastrointestinal system autoimmune disease",
          "alimentary part of gastrointestinal system hypersensitivity reaction type II disease",
          "autoimmune disease of alimentary part of gastrointestinal system"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A hypersensitivity reaction type II disease that involves the alimentary part of gastrointestinal system."
      },
      "child_count": 14,
      "reference_id": "MONDO:0000588"
    },
    {
      "id": 4367,
      "label": "hepatitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6878,
        20399
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2237",
          "ICD9:570",
          "ICD9:571.4",
          "ICD9:571.40",
          "ICD9:571.41",
          "MEDGEN:5515",
          "MESH:D006505",
          "NCIT:C3095",
          "SCTID:197268000",
          "UMLS:C0019158"
        ],
        "synonyms": [
          "Hepatitis",
          "hepatitis",
          "inflammation of liver",
          "liver inflammation",
          "acute and subacute liver necrosis",
          "acute hepatitis",
          "acute/subac. necrosis of liver",
          "animal hepatitis",
          "chronic hepatitis",
          "chronic persistent hepatitis",
          "Hepatitides"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An active inflammatory process affecting the liver for more than six months. Causes include viral infections, autoimmune disorders, drugs, and metabolic disorders."
      },
      "child_count": 18,
      "reference_id": "MONDO:0002251"
    }
  ],
  "children": [
    {
      "id": 7195,
      "label": "autoimmune hepatitis type 1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022251",
          "ICD9:571.49",
          "MEDGEN:928833",
          "Orphanet:563576",
          "SCTID:197284004",
          "SCTID:721711009",
          "UMLS:C4303164",
          "icd11.foundation:260422751"
        ],
        "synonyms": [
          "autoimmune hepatitis type 1",
          "type 1 AIH"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Autoimmune hepatitis characterized by the presence of antinuclear antibody (ANA) and antismooth-muscle antibody (ASMA)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0005543"
    },
    {
      "id": 20406,
      "label": "autoimmune hepatitis type 2",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022252",
          "MEDGEN:928832",
          "Orphanet:563581",
          "SCTID:721712002",
          "UMLS:C4303163",
          "icd11.foundation:61111843"
        ],
        "synonyms": [
          "autoimmune hepatitis type 2",
          "type 2 AIH"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Autoimmune hepatitis characterized by the presence of anti-liver kidney microsomal antibody type 1 (anti-LKM1) and/or anti-liver cytosol type 1 (anti-LC1) autoantibodies."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021176"
    },
    {
      "id": 20407,
      "label": "autoimmune hepatitis type 3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025298",
          "MEDGEN:928831",
          "SCTID:721713007",
          "UMLS:C4303162",
          "icd11.foundation:607786920"
        ],
        "synonyms": [
          "autoimmune hepatitis type 3"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Autoimmune hepatitis characterized by the presence of antibodies to soluble liver or liver-pancreas antigens."
      },
      "child_count": 0,
      "reference_id": "MONDO:0021177"
    },
    {
      "id": 22780,
      "label": "primary biliary cholangitis/primary sclerosing cholangitis and autoimmune hepatitis overlap syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6556,
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022250",
          "MEDGEN:1812237",
          "Orphanet:562639",
          "UMLS:C5680117"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0034189"
    },
    {
      "id": 22832,
      "label": "seronegative autoimmune hepatitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0022253",
          "MEDGEN:1804383",
          "Orphanet:563589",
          "UMLS:C5680121"
        ],
        "synonyms": [
          "Seronegative AIH",
          "autoantibody-negative autoimmune hepatitis"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A form of autoimmune hepatitis characterized by the features of classic autoimmune hepatitis (i. e. clinical presentation as acute or chronic cryptogenic hepatitis, interface hepatitis on histological examination, elevated serum aspartate aminotransferase and alanine aminotransferase levels, hypergammaglobulinemia/elevated immunoglobulin G, therapeutic response to corticosteroids) in the absence of serum autoantibodies. Clinical manifestations include fatigue, malaise, arthralgia, jaundice, at later stages also signs of advanced chronic liver disease, such as spider nevi, caput medusae, splenomegaly, ascites, and palmar erythema. Presence of concurrent autoimmune diseases is frequently observed."
      },
      "child_count": 0,
      "reference_id": "MONDO:0035400"
    },
    {
      "id": 25178,
      "label": "autoimmune cholangitis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6556,
        16828
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080742",
          "GARD:0026594",
          "MEDGEN:881331",
          "UMLS:C4075851"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An autoimmune hepatitis that is characterized by primary biliary cirrhosis clinical, biochemical, and histologic characteristics with antinuclear antibody positive sera."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850225"
    },
    {
      "id": 29332,
      "label": "giant cell hepatitis with autoimmune hemolytic anemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16828,
        19736
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0028171"
        ],
        "synonyms": [
          "GCH-AHA",
          "giant cell hepatitis associated with autoimmune hemolytic anemia",
          "giant cell hepatitis with autoimmune haemolytic anaemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0004335",
            "name": "digestive system disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A rare autoimmune disease of early childhood, marked by the simultaneous or sequential immune attack on red blood cells and liver cells."
      },
      "child_count": 0,
      "reference_id": "MONDO:1060166"
    }
  ],
  "roots": [
    {
      "id": 2997,
      "label": "autoimmune disorder of endocrine system"
    },
    {
      "id": 3002,
      "label": "autoimmune disorder of exocrine system"
    },
    {
      "id": 3004,
      "label": "autoimmune disorder of gastrointestinal tract"
    },
    {
      "id": 4367,
      "label": "hepatitis"
    }
  ]
}