{
  "id": 16870,
  "label": "progressive multifocal leukoencephalopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016318",
  "properties": {
    "xrefs": [
      "DOID:643",
      "EFO:0007455",
      "GARD:0007468",
      "ICD10CM:A81.2",
      "ICD9:046.3",
      "MEDGEN:7327",
      "MESH:D007968",
      "MedDRA:10036807",
      "NANDO:1200205",
      "NCIT:C26815",
      "NORD:1616",
      "Orphanet:217260",
      "SCTID:22255007",
      "UMLS:C0023524",
      "icd11.foundation:902939755"
    ],
    "synonyms": [
      "PML",
      "progressive multifocal leukoencephalitis",
      "leukoencephalopathy, progressive multifocal"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Progressive multifocal leukoencephalopathy (PML) is a neurological disorder that damages the myelin that covers and protects nerves in the white matter of the brain. It is caused by the JC virus (JCV). By age 10, most people have been infected with this virus, but itrarelycauses symptoms unless the immune system becomes severely weakened.The disease occurs, rarely, in organ transplant patients; people undergoing chronic corticosteroid or immunosuppressive therapy; and individuals with cancer, such as Hodgkins disease, lymphoma, and sarcoidosis. PML is most common among individuals with acquired immune deficiency syndrome (AIDS)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19721,
      "label": "infectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025151",
          "ICD9:049.8",
          "ICD9:323.4",
          "MEDGEN:108917",
          "MESH:D000069544",
          "NCIT:C79550",
          "SCTID:312215006",
          "UMLS:C0596773"
        ],
        "synonyms": [
          "encephalitis infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020067"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19721,
      "label": "infectious encephalitis"
    }
  ]
}