{
  "id": 16883,
  "label": "non-familial restrictive cardiomyopathy",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016345",
  "properties": {
    "xrefs": [
      "GARD:0020535",
      "MEDGEN:1843079",
      "NANDO:1200294",
      "Orphanet:217720",
      "UMLS:C5680885",
      "icd11.foundation:2097520643"
    ],
    "categories": [
      {
        "ref": "MONDO:0002081",
        "name": "musculoskeletal system disorder"
      },
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 7,
  "parents": [
    {
      "id": 6919,
      "label": "restrictive cardiomyopathy",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:397",
          "EFO:0002630",
          "GARD:0020531",
          "ICD9:425.4",
          "MEDGEN:40111",
          "MESH:D002313",
          "MedDRA:10038748",
          "NANDO:1200292",
          "NANDO:1200293",
          "NANDO:2100058",
          "NANDO:2200233",
          "NCIT:C62798",
          "Orphanet:217632",
          "SCTID:415295002",
          "UMLS:C0007196",
          "icd11.foundation:316495940"
        ],
        "synonyms": [
          "restrictive cardiomyopathy",
          "familial restrictive cardiomyopathy"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A type of heart disorder referring to the inability of the ventricles to fill with blood because the myocardium (heart muscle) stiffens and looses its flexibility. Causes include replacement of the myocardium with scar tissue, abnormal cellular infiltration of the myocardium, or deposition of a substance (e.g., amyloid) in the myocardium."
      },
      "child_count": 3,
      "reference_id": "MONDO:0005201"
    }
  ],
  "children": [
    {
      "id": 3895,
      "label": "cardiac sarcoidosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16883,
        19178
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:13405",
          "GARD:0022992",
          "MEDGEN:140260",
          "NCIT:C35589",
          "SCTID:75403004",
          "UMLS:C0392077"
        ],
        "synonyms": [
          "heart sarcoidosis",
          "sarcoidosis of heart"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Sarcoidosis affecting the tissues of the heart."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001707"
    },
    {
      "id": 16456,
      "label": "hypereosinophilic syndrome",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4370,
        16883,
        23489
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:999",
          "EFO:1001467",
          "GARD:0002804",
          "ICD10CM:D72.11",
          "ICD9:288.3",
          "ICDO:9964/3",
          "MEDGEN:280990",
          "MESH:D017681",
          "MedDRA:10048643",
          "NANDO:2200805",
          "NANDO:2200806",
          "NCIT:C27038",
          "Orphanet:168956",
          "SCTID:419455006",
          "UMLS:C1540912",
          "icd11.foundation:110429919"
        ],
        "synonyms": [
          "HES",
          "hypereosinophilic disease",
          "hypereosinophilic disorder",
          "hypereosinophilic syndrome",
          "eosinophilia"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hypereosinophilic syndrome (HES) constitutes a rare and heterogeneous group of disorders, defined as persistent and marked blood eosinophilia and/or tissue eosinophilia associated with a wide range of clinical manifestations reflecting eosinophil-induced tissue/organ damage."
      },
      "child_count": 24,
      "reference_id": "MONDO:0015691"
    },
    {
      "id": 18192,
      "label": "wild type ATTR amyloidosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16883,
        18960
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080937",
          "GARD:0021501",
          "ICD10CM:E85.82",
          "ICD9:277.39",
          "MEDGEN:87446",
          "NANDO:1200212",
          "Orphanet:330001",
          "SCTID:237877004",
          "UMLS:C0342623",
          "icd11.foundation:25699053"
        ],
        "synonyms": [
          "ATTRwt amyloidosis",
          "ATTRwt-related amyloidosis",
          "SSA",
          "Senile systemic amyloidosis",
          "wild type ATTR-related amyloidosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0018018"
    },
    {
      "id": 19035,
      "label": "tropical endomyocardial fibrosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16883
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0018928",
          "MEDGEN:909153",
          "Orphanet:75565",
          "SCTID:715626008",
          "UMLS:C2882252"
        ],
        "synonyms": [
          "Davies disease",
          "TEMF"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Tropical endomyocardial fibrosis is a restrictive cardiopathy, occurring almost exclusively in children and young adults in tropical and subtropical regions, characterized by endocardial fibrosis, affecting the apices and the inflow tract of the right or left ventricle (or both) and manifesting with a restrictive cardimyopathy and atrioventricular regurgitation leading to severe pulmonary hypertension, very high systemic venous pressure and congestive cardiac failure. Suspected etiologies include helminth and protozoal infestation and malnutrition."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019158"
    },
    {
      "id": 19036,
      "label": "Loeffler endocarditis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16883
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:396",
          "GARD:0018929",
          "MEDGEN:104788",
          "MedDRA:10052841",
          "NCIT:C27044",
          "Orphanet:75566",
          "SCTID:449829009",
          "UMLS:C0206143",
          "icd11.foundation:1223390562"
        ],
        "synonyms": [
          "eosinophilic endocarditis",
          "eosinophilic endomyocardial disease"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "Loeffler's endocarditis is a rare restrictive cardiomyopathy characterized by hypereosinophilia and fibrous thickening of the endocardium, with usually large thrombi against the ventricle walls, that can lead to cardiovascular complications such as heart failure and thromboembolism. It manifests with symptoms like edema, fatigue and shortness of breath. It is usually secondary to eosinophil-associated tissue damage and is associated with idiopathic hypereosinophilic syndrome, chronic eosinophilic leukemia, carcinoma, or lymphoma."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019159"
    },
    {
      "id": 19265,
      "label": "AL amyloidosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        7996,
        16875,
        16883,
        18960
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080933",
          "GARD:0005797",
          "MEDGEN:75674",
          "MESH:C531616",
          "MedDRA:10036673",
          "NANDO:1200211",
          "NCIT:C158963",
          "Orphanet:85443",
          "UMLS:C0268381",
          "icd11.foundation:1061366491",
          "icd11.foundation:113043090"
        ],
        "synonyms": [
          "Light-chain amyloidosis",
          "primary amyloidosis",
          "Light chain amyloidosis",
          "amyloidosis AL",
          "amyloidosis primary systemic",
          "primary AL amyloidosis",
          "primary systemic AL amyloidosis",
          "primary systemic amyloidosis",
          "systemic AL amyloidsis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "AL Amyloidosis is a plasma cell disorder characterized by the aggregation and deposition of insoluble amyloid fibrils derived from misfolding of monoclonal immunoglobulin light chains usually produced by a plasma cell tumor. It usually presents as primary systemic amyloidosis (PSA) with multiple organ involvement and less frequently as primary localized amyloidosis (PLA) restricted to a single organ."
      },
      "child_count": 10,
      "reference_id": "MONDO:0019438"
    },
    {
      "id": 19266,
      "label": "AA amyloidosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        6799,
        16883,
        18960
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080936",
          "GARD:0010560",
          "ICD9:277.39",
          "MEDGEN:782429",
          "MedDRA:10039811",
          "NCIT:C3818",
          "Orphanet:85445",
          "SCTID:281034005",
          "UMLS:C3536715",
          "icd11.foundation:570181034"
        ],
        "synonyms": [
          "inflammatory amyloidosis",
          "reactive amyloidosis",
          "secondary amyloidosis",
          "amyloid A amyloidosis",
          "amyloidosis AA"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Secondary amyloidosis is a form of amyloidosis, that complicates chronic inflammatory disorders (mainly rheumatoid arthritis) and is characterized by the aggregation and deposition of amyloid fibrils composed of serum amyloid A protein, an acute phase reactant. Although spleen, suprarenal gland, liver and gut are frequent sites of amyloid deposition, the clinical picture is dominated by renal involvement."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019439"
    }
  ],
  "roots": [
    {
      "id": 6919,
      "label": "restrictive cardiomyopathy"
    }
  ]
}