{
  "id": 16890,
  "label": "diffuse cutaneous systemic sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016356",
  "properties": {
    "xrefs": [
      "GARD:0009751",
      "NANDO:1201010",
      "NCIT:C116791",
      "Orphanet:220393"
    ],
    "synonyms": [
      "dSSc",
      "diffuse cutaneous systemic scleroderma",
      "progressive cutaneous systemic scleroderma",
      "progressive cutaneous systemic sclerosis",
      "DcSSc"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Diffuse cutaneous systemic sclerosis (dcSSc) is a subtype of Systemic Sclerosis (SSc) characterized by truncal and acral skin fibrosis with an early and significant incidence of diffuse involvement (interstitial lung disease, oliguric renal failure, diffuse gastrointestinal disease, and myocardial involvement)."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 6827,
      "label": "systemic sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        19180
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:418",
          "EFO:0000717",
          "GARD:0009748",
          "ICD10CM:M34",
          "ICD10WHO:M34",
          "ICD9:710.1",
          "MEDGEN:19897",
          "MESH:D012595",
          "MedDRA:10042953",
          "NANDO:1200277",
          "NANDO:2200429",
          "NCIT:C72070",
          "NORD:2007",
          "Orphanet:90291",
          "SCTID:89155008",
          "UMLS:C0036421",
          "icd11.foundation:1084365812"
        ],
        "synonyms": [
          "Scleroderma",
          "PSS (progressive systemic sclerosis)",
          "SSc",
          "SSc, diffuse sclerosis",
          "Scleroderma (& [systemic sclerosis])",
          "Scleroderma, diffuse",
          "Scleroderma, systemic",
          "Systemic Scleroderma",
          "diffuse Scleroderma",
          "diffuse sclerosis",
          "systemic Scleroderma",
          "systemic scleroderma",
          "systemic sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005100"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 6827,
      "label": "systemic sclerosis"
    }
  ]
}