{
  "id": 16892,
  "label": "limited cutaneous systemic sclerosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016358",
  "properties": {
    "xrefs": [
      "DOID:1577",
      "GARD:0001053",
      "MEDGEN:148187",
      "MESH:D045745",
      "NANDO:1201011",
      "Orphanet:220402",
      "SCTID:298285004",
      "SCTID:299276009",
      "UMLS:C0748540"
    ],
    "synonyms": [
      "limited cutaneous systemic scleroderma",
      "limited scleroderma"
    ],
    "categories": [
      {
        "ref": "MONDO:0002051",
        "name": "integumentary system disorder"
      },
      {
        "ref": "MONDO:0003900",
        "name": "connective tissue disorder"
      },
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      }
    ],
    "definition": "Limited cutaneous systemic sclerosis (lcSSc) is a subtype of systemic sclerosis (SSc) characterized by the association of Raynaud's phenomenon with skin fibrosis limited to the hands, face, feet and forearms."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 6827,
      "label": "systemic sclerosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6820,
        19180
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:418",
          "EFO:0000717",
          "GARD:0009748",
          "ICD10CM:M34",
          "ICD10WHO:M34",
          "ICD9:710.1",
          "MEDGEN:19897",
          "MESH:D012595",
          "MedDRA:10042953",
          "NANDO:1200277",
          "NANDO:2200429",
          "NCIT:C72070",
          "NORD:2007",
          "Orphanet:90291",
          "SCTID:89155008",
          "UMLS:C0036421",
          "icd11.foundation:1084365812"
        ],
        "synonyms": [
          "Scleroderma",
          "PSS (progressive systemic sclerosis)",
          "SSc",
          "SSc, diffuse sclerosis",
          "Scleroderma (& [systemic sclerosis])",
          "Scleroderma, diffuse",
          "Scleroderma, systemic",
          "Systemic Scleroderma",
          "diffuse Scleroderma",
          "diffuse sclerosis",
          "systemic Scleroderma",
          "systemic scleroderma",
          "systemic sclerosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "A chronic disorder, possibly autoimmune, marked by excessive production of collagen which results in hardening and thickening of body tissues. The two types of systemic scleroderma, limited cutaneous and diffuse cutaneous are classified with focus on the extent of affected skin. A relationship exists between the extent of skin area affected and degree of internal organ/system involvement. Systemic scleroderma can manifest itself in pulmonary fibrosis, Raynaud's syndrome, digestive system telangiectasias, renal hypertension and/or pulmonary hypertension."
      },
      "child_count": 12,
      "reference_id": "MONDO:0005100"
    }
  ],
  "children": [
    {
      "id": 19370,
      "label": "CREST syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4370,
        16892
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060218",
          "GARD:0025139",
          "MEDGEN:60083",
          "MESH:D017675",
          "MedDRA:10011380",
          "NANDO:1201011",
          "NCIT:C70646",
          "Orphanet:90290",
          "SCTID:31848007",
          "UMLS:C0206138"
        ],
        "synonyms": [
          "lcSSc",
          "calcinosis-Raynaud phenomenon-esophageal involvement-sclerodactyly-telangiectasia syndrome",
          "limited cutaneous Systemic Scleroderma",
          "limited cutaneous Systemic sclerosis",
          "CRST syndrome",
          "CRST syndromes",
          "calcinosis - Raynaud phenomenon - esophageal involvement - sclerodactyly - telangiectasia",
          "calcinosis Raynaud phenomenon sclerodactyly telangiectasia",
          "calcinosis, Raynaud's phenomenon, esophageal dismobility, sclerodactyly, telangiectasia syndrome",
          "calcinosis-Raynaud phenomenon-sclerodactyly-telangiectasia",
          "phenomenon-sclerodactyly-telangiectasia, calcinosis-Raynaud",
          "syndrome, CREST"
        ],
        "categories": [
          {
            "ref": "MONDO:0002051",
            "name": "integumentary system disorder"
          },
          {
            "ref": "MONDO:0002254",
            "name": "syndromic disease"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          }
        ],
        "definition": "CREST syndrome is a subtype of limited cutaneous systemic sclerosis (lcSSc) whose name is an acronym for the cardinal clinical features of the syndrome: calcinosis, Raynaud's phenomenon, esophageal dysmotility, sclerodactyly and telangiectasia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019563"
    }
  ],
  "roots": [
    {
      "id": 6827,
      "label": "systemic sclerosis"
    }
  ]
}