{
  "id": 16961,
  "label": "autoimmune hemolytic anemia, cold type",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016450",
  "properties": {
    "xrefs": [
      "GARD:0020590",
      "MEDGEN:104501",
      "Orphanet:228312",
      "UMLS:C0175816",
      "icd11.foundation:1836938544"
    ],
    "synonyms": [
      "cAHA",
      "cAIHA",
      "cold AIHA"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Cold autoimmune hemolytic anemia comprises two types of autoimmune hemolytic anemia (AIHA) defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C): cold agglutinin disease (CAD), which is the more common, and paroxysmal cold hemoglobinuria (PCH)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 19736,
      "label": "autoimmune hemolytic anemia",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        3016,
        5550
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "CSP:0427-1178",
          "DOID:718",
          "EFO:1001264",
          "GARD:0005870",
          "ICD9:283.0",
          "MEDGEN:1918",
          "MESH:D000744",
          "MedDRA:10002046",
          "NANDO:1200305",
          "NANDO:2100181",
          "NCIT:C34378",
          "NORD:774",
          "OMIM:205700",
          "Orphanet:98375",
          "SCTID:413603009",
          "UMLS:C0002880",
          "icd11.foundation:1834341306"
        ],
        "synonyms": [
          "AHA",
          "AIHA",
          "Anemia, Hemolytic, Acquired Autoimmune",
          "autoimmune haemolytic anemia",
          "autoimmune hemolytic anemia",
          "acquired autoimmune hemolytic anaemia",
          "acquired autoimmune hemolytic anemia",
          "anaemia hemolytic autoimmune",
          "anemia hemolytic autoimmune",
          "anemia, autoimmune hemolytic",
          "familial auto-immune hemolytic anaemia (subtype)",
          "familial auto-immune hemolytic anemia (subtype)",
          "idiopathic autoimmune hemolytic anaemia",
          "idiopathic autoimmune hemolytic anemia",
          "immuno-hemolytic anaemia",
          "immuno-hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Autoimmune hemolytic anemia (AIHA) is an autoimmune disorder in which various types of auto-antibodies are directed against red blood cells causing their survival to be shortened and resulting in hemolytic anemia."
      },
      "child_count": 14,
      "reference_id": "MONDO:0020108"
    }
  ],
  "children": [
    {
      "id": 18846,
      "label": "cold agglutinin disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16961
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0006130",
          "ICD10CM:D59.12",
          "MEDGEN:688249",
          "NANDO:1200307",
          "NANDO:2200618",
          "NORD:775",
          "Orphanet:56425",
          "SCTID:127055007",
          "UMLS:C1264008"
        ],
        "synonyms": [
          "CAD",
          "CAS",
          "chronic cold agglutinin disease",
          "cold agglutinin syndrome",
          "anemia, hemolytic, cold antibody",
          "cold antibody disease",
          "cold antibody hemolytic anaemia",
          "cold antibody hemolytic anemia"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Cold agglutinin disease is a type of autoimmune hemolytic anemia defined by the presence of cold autoantibodies (autoantibodies which are active at temperatures below 30B0C)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0018922"
    },
    {
      "id": 19343,
      "label": "paroxysmal cold hemoglobinuria",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        16961
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0007335",
          "MEDGEN:39693",
          "NANDO:1200308",
          "NANDO:2200619",
          "NORD:1556",
          "Orphanet:90035",
          "SCTID:127057004",
          "UMLS:C0086774",
          "icd11.foundation:715111132"
        ],
        "synonyms": [
          "Donath-Landsteiner hemolytic anaemia",
          "Donath-Landsteiner hemolytic anemia",
          "Donath-Landsteiner syndrome",
          "PCH",
          "hemoglobinuria paroxysmal cold"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Paroxysmal cold hemoglobinuria (PCH) is a very rare subtype of autoimmune hemolytic anemia (AIHA), caused by the presence of cold-reacting autoantibodies in the blood and characterized by the sudden presence of hemoglobinuria, typically after exposure to cold temperatures."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019533"
    }
  ],
  "roots": [
    {
      "id": 19736,
      "label": "autoimmune hemolytic anemia"
    }
  ]
}