{
  "id": 17010,
  "label": "aldosterone-producing adrenal cortex adenoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016505",
  "properties": {
    "xrefs": [
      "EFO:1000015",
      "GARD:0020621",
      "MEDGEN:353374",
      "MedDRA:10056950",
      "NCIT:C48451",
      "Orphanet:231625",
      "UMLS:C1706762"
    ],
    "synonyms": [
      "APAC",
      "Pure APAC",
      "Pure aldosterone-producing adrenocortical carcinoma",
      "Pure aldosterone-secreting adrenocortical carcinoma",
      "aldosterone producing adrenal cortex adenoma",
      "aldosterone producing adrenal cortical adenoma",
      "aldosterone-producing adrenal cortex adenoma",
      "adrenocortical carcinoma with pure aldosterone hypersecretion"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "An adenoma of the adrenal cortex that produces aldosterone. It may be associated with Conn syndrome. Clinical presentation includes hypertension, hypokalemia, and muscle weakness."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 3643,
      "label": "primary aldosteronism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5007
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:12028",
          "ICD10CM:E26.0",
          "ICD10CM:E26.01",
          "ICD9:255.12",
          "MEDGEN:278002",
          "NANDO:2200361",
          "NCIT:C34510",
          "SCTID:190507007",
          "UMLS:C1384514",
          "icd11.foundation:197924221"
        ],
        "synonyms": [
          "Conn syndrome",
          "Conn's syndrome",
          "primary aldosteronism",
          "primary hyperaldosteronism"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An endocrine disorder characterized by excessive production of aldosterone by the adrenal glands. Causes include adrenal gland adenoma and adrenal gland hyperplasia. The overproduction of aldosterone results in sodium and water retention and hypokalemia. Patients present with high blood pressure, muscle weakness, and headache."
      },
      "child_count": 4,
      "reference_id": "MONDO:0001422"
    },
    {
      "id": 5783,
      "label": "adrenal cortex adenoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6714,
        20630,
        22943,
        22952
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050891",
          "DOID:656",
          "EFO:0003104",
          "GARD:0027656",
          "HP:0008196",
          "HP:0008256",
          "ICDO:8370/0",
          "MEDGEN:61654",
          "MESH:D018246",
          "NANDO:2200352",
          "NCIT:C9003",
          "ONCOTREE:ACA",
          "Orphanet:99888",
          "SCTID:302826002",
          "UMLS:C0206667"
        ],
        "synonyms": [
          "adenoma of adrenal cortex",
          "adenoma of adrenal gland",
          "adenoma of the adrenal cortex",
          "adenoma of the adrenal gland",
          "adenoma, adrenocortical, benign",
          "adrenal adenoma",
          "adrenal cortex adenoma",
          "adrenal cortical adenoma",
          "adrenal gland adenoma",
          "adrenocortical adenoma",
          "benign adenoma of adrenal gland",
          "benign adenoma of the adrenal gland",
          "benign adrenal adenoma",
          "benign adrenal gland adenoma",
          "cortical cell adenoma",
          "adrenal incidentaloma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign neoplasm that can arise from any of the adrenal cortical layers. It can be associated with the overproduction of glucocorticoids (Cushing's syndrome), androgenic or estrogenic steroids (adrenogenital syndrome), or mineralocorticoids (Conn's syndrome). (Sternberg Diagnostic Surgical Pathology, 3rd ed.)"
      },
      "child_count": 16,
      "reference_id": "MONDO:0003924"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 3643,
      "label": "primary aldosteronism"
    },
    {
      "id": 5783,
      "label": "adrenal cortex adenoma"
    }
  ]
}