{
  "id": 17050,
  "label": "transient congenital hypothyroidism due to maternal factor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016555",
  "properties": {
    "xrefs": [
      "GARD:0020645",
      "MEDGEN:1842783",
      "Orphanet:238696",
      "UMLS:C5680929"
    ],
    "categories": [
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 16545,
      "label": "transient congenital hypothyroidism",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18613
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020142",
          "MEDGEN:820541",
          "NCIT:C113171",
          "Orphanet:178045",
          "SCTID:119181000119104",
          "UMLS:C3827793",
          "icd11.foundation:592246939"
        ],
        "synonyms": [
          "THOP",
          "hypothyroxinemia of prematurity",
          "transient hypothyroxinemia of prematurity"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A common, self-limiting thyroid disorder seen in preterm infants that is characterized by abnormally low serum levels of thyroxine and free thyroxine with normal serum levels of thyroid stimulating hormone."
      },
      "child_count": 2,
      "reference_id": "MONDO:0015792"
    }
  ],
  "children": [
    {
      "id": 10467,
      "label": "fetal iodine syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17050,
        17143
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002304",
          "MEDGEN:907922",
          "OMIM:228355",
          "Orphanet:1910",
          "SCTID:718228001",
          "UMLS:C4273860"
        ],
        "synonyms": [
          "FIDD",
          "endemic cretinism",
          "fetal iodine deficiency disorder",
          "foetal iodine deficiency disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Fetal iodine syndrome refers to symptoms and signs that may be observed in a fetus or newborn when the mother was exposed during pregnancy to inappropriate (insufficient or excessive) amounts of iodine. Iodine deficiency is associated with goiter and hypothyroidism. When severe iodine deficiency occurs during pregnancy, it is associated with congenital hypothyroidism that is manifested by increased neonatal morbi-mortality and severe mental dysfunction, hyperactivity, attention disorders and a substantial decrease of IQ of an irreversible nature. Excessive iodine ingestion during the third trimester of pregnancy can result in hypothyroidism and fetal goiter due to a prolonged inhibition of thyroid hormone synthesis, an increase in thyrotropin (TSH)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009224"
    },
    {
      "id": 16930,
      "label": "congenital hypothyroidism due to maternal intake of antithyroid drugs",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17050
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020563",
          "MEDGEN:1673658",
          "Orphanet:226313",
          "UMLS:C5190849"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0016413"
    },
    {
      "id": 19581,
      "label": "congenital hypothyroidism due to transplacental passage of maternal TSH-binding inhibitory antibodies",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17050
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0019297",
          "MEDGEN:903571",
          "Orphanet:95715",
          "SCTID:717333002",
          "UMLS:C4273914"
        ],
        "categories": [
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "Congenital hypothyroidism due to transplacental passage of maternal thyroid-stimulating hormone (TSH)-binding inhibitory antibodies is a type of transient congenital hypothyroidism, a thyroid hormone deficiency that is not permanent."
      },
      "child_count": 0,
      "reference_id": "MONDO:0019857"
    }
  ],
  "roots": [
    {
      "id": 16545,
      "label": "transient congenital hypothyroidism"
    }
  ]
}