{
  "id": 17144,
  "label": "high grade astrocytic tumor",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016680",
  "properties": {
    "xrefs": [
      "GARD:0020704",
      "MEDGEN:769639",
      "NCIT:C102897",
      "Orphanet:251561",
      "UMLS:C3640999"
    ],
    "synonyms": [
      "high grade astrocytic neoplasm",
      "high grade astrocytic tumor",
      "high-grade astrocytic neoplasm",
      "high-grade astrocytic tumor",
      "high-grade astrocytic tumour",
      "high-grade astrocytoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 20692,
      "label": "astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3069",
          "GARD:0012928",
          "MedDRA:10003571",
          "NCIT:C6958",
          "Orphanet:94"
        ],
        "synonyms": [
          "astrocytic neoplasm",
          "astrocytic tumor",
          "astrocytoma, no ICD-O subtype",
          "astroglioma",
          "astrocytoma",
          "astrocytoma of cerebrum"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glial tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, subependymal giant cell astrocytoma, and glioblastoma."
      },
      "child_count": 8,
      "reference_id": "MONDO:0021636"
    },
    {
      "id": 24071,
      "label": "malignant glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20078,
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3070",
          "GARD:0026148",
          "ICDO:9380/3",
          "MEDGEN:107826",
          "MedDRA:10018338",
          "NCIT:C4822",
          "UMLS:C0555198"
        ],
        "synonyms": [
          "glioma",
          "neuroglial tumor",
          "neuroglial tumour",
          "glial cell tumour",
          "glioma, malignant",
          "high grade glioma",
          "high-grade glioma",
          "malignant glial neoplasm",
          "malignant glial tumor",
          "malignant glial tumour",
          "malignant glioma",
          "malignant neuroglial neoplasm",
          "malignant neuroglial tumor",
          "malignant neuroglial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade III or grade IV glioma arising from the central nervous system. This category includes glioblastoma, anaplastic astrocytoma, anaplastic ependymoma, anaplastic oligodendroglioma, and anaplastic oligoastrocytoma."
      },
      "child_count": 36,
      "reference_id": "MONDO:0100342"
    }
  ],
  "children": [
    {
      "id": 17147,
      "label": "gliomatosis cerebri",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        7155,
        17144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6128",
          "GARD:0006514",
          "ICDO:9381/3",
          "MEDGEN:87267",
          "MedDRA:10066254",
          "NCIT:C4318",
          "Orphanet:251582",
          "UMLS:C0334576",
          "icd11.foundation:373131154"
        ],
        "synonyms": [
          "astrocytosis cerebri",
          "gliomatosis",
          "gliomatosis cerebri",
          "gliomatosis cerebri (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A diffuse glial tumor which infiltrates the brain extensively, involving more than two lobes. It is frequently bilateral and often extends to the infratentorial structures, even to the spinal cord. It is probably of astrocytic origin, although GFAP expression may be scant or absent. (Adapted from WHO.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016683"
    },
    {
      "id": 17148,
      "label": "anaplastic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144,
        19525,
        20048
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3078",
          "EFO:0002499",
          "GARD:0005860",
          "ICDO:9401/3",
          "MEDGEN:137784",
          "MedDRA:10002224",
          "MedDRA:10060971",
          "NANDO:2200086",
          "NCIT:C9477",
          "NORD:769",
          "ONCOTREE:AASTR",
          "Orphanet:251589",
          "UMLS:C0334579"
        ],
        "synonyms": [
          "anaplastic astrocytoma",
          "astrocytoma, anaplastic, malignant",
          "grade III astrocytic neoplasm",
          "grade III astrocytic tumor",
          "grade III astrocytic tumour",
          "grade III astrocytoma",
          "malignant astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord."
      },
      "child_count": 9,
      "reference_id": "MONDO:0016684"
    },
    {
      "id": 18320,
      "label": "glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17144
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3068",
          "EFO:0000519",
          "GARD:0002491",
          "HP:0012174",
          "HP:0100843",
          "ICDO:9440/3",
          "MEDGEN:42228",
          "MESH:D005909",
          "MedDRA:10018336",
          "MedDRA:10018337",
          "NANDO:2200087",
          "NCIT:C3058",
          "NORD:1187",
          "ONCOTREE:GB",
          "ONCOTREE:GBM",
          "Orphanet:360",
          "SCTID:393563007",
          "UMLS:C0017636"
        ],
        "synonyms": [
          "GBM",
          "GBM (glioblastoma)",
          "WHO grade IV glioma",
          "glioblastoma",
          "glioblastoma (disease)",
          "glioblastoma multiforme",
          "glioblastoma multiforme (disease)",
          "grade IV astrocytic neoplasm",
          "grade IV astrocytic tumor",
          "grade IV astrocytic tumour",
          "grade IV astrocytoma",
          "spongioblastoma multiforme",
          "grade IV adult astrocytic tumor",
          "grade IV adult astrocytic tumour",
          "giant cell glioblastoma (histologic variant)",
          "gliosarcoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The most malignant astrocytic tumor (WHO grade IV). It is composed of poorly differentiated neoplastic astrocytes and it is characterized by the presence of cellular polymorphism, nuclear atypia, brisk mitotic activity, vascular thrombosis, microvascular proliferation and necrosis. It typically affects adults and is preferentially located in the cerebral hemispheres. It may develop from diffuse astrocytoma WHO grade II or anaplastic astrocytoma (secondary glioblastoma, IDH-mutant), but more frequently, it manifests after a short clinical history de novo, without evidence of a less malignant precursor lesion (primary glioblastoma, IDH- wildtype). (Adapted from WHO)"
      },
      "child_count": 7,
      "reference_id": "MONDO:0018177"
    }
  ],
  "roots": [
    {
      "id": 20692,
      "label": "astrocytic tumor"
    },
    {
      "id": 24071,
      "label": "malignant glioma"
    }
  ]
}