{
  "id": 17146,
  "label": "giant cell glioblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016682",
  "properties": {
    "xrefs": [
      "DOID:3074",
      "GARD:0020705",
      "ICDO:9441/3",
      "MEDGEN:83169",
      "NCIT:C4325",
      "Orphanet:251579",
      "UMLS:C0334588",
      "icd11.foundation:565094124"
    ],
    "synonyms": [
      "Monstrocellular sarcoma [obs]"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare histological variant of glioblastoma (WHO grade IV) with a predominance of bizarre, multinucleated giant cells, an occasionally abundant stromal reticulin network, and a high frequency of TP53 mutations. (WHO)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 4576,
      "label": "brain glioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7155,
        18320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3073",
          "EFO:0006545",
          "GARD:0023150",
          "MEDGEN:138100",
          "NCIT:C4642",
          "SCTID:276828006",
          "UMLS:C0349543"
        ],
        "synonyms": [
          "brain glioblastoma",
          "brain glioblastoma (disease)",
          "brain glioblastoma multiforme",
          "brain glioblastoma multiforme (disease)",
          "glioblastoma multiforme of brain",
          "glioblastoma multiforme of the brain",
          "grade IV astrocytic tumour of brain",
          "grade IV brain astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade IV malignant astrocytic tumor that arises from the brain, usually the cerebral hemispheres. It is characterized by the presence of poorly differentiated astrocytes, cellular polymorphism, nuclear atypia, and increased mitotic activity. The prognosis is poor."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002501"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 4576,
      "label": "brain glioblastoma"
    }
  ]
}