{
  "id": 17148,
  "label": "anaplastic astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016684",
  "properties": {
    "xrefs": [
      "DOID:3078",
      "EFO:0002499",
      "GARD:0005860",
      "ICDO:9401/3",
      "MEDGEN:137784",
      "MedDRA:10002224",
      "MedDRA:10060971",
      "NANDO:2200086",
      "NCIT:C9477",
      "NORD:769",
      "ONCOTREE:AASTR",
      "Orphanet:251589",
      "UMLS:C0334579"
    ],
    "synonyms": [
      "anaplastic astrocytoma",
      "astrocytoma, anaplastic, malignant",
      "grade III astrocytic neoplasm",
      "grade III astrocytic tumor",
      "grade III astrocytic tumour",
      "grade III astrocytoma",
      "malignant astrocytoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Anaplastic astrocytoma is a rare, high-grade, malignant glial tumor, histologically characterized by abundance of pleomorphic astrocytes and multiple mitotic figures, often associated with diffuse infiltration of the surrounding tissue, considerable edema and mass effect and involvement of the contralateral brain. Depending on the primary localization of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), seizures, progressive neurological deficits, and/or behavioral changes. The tumor is most commonly localized in the frontal and temporal lobes, brain stem and spinal cord."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 17144,
      "label": "high grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020704",
          "MEDGEN:769639",
          "NCIT:C102897",
          "Orphanet:251561",
          "UMLS:C3640999"
        ],
        "synonyms": [
          "high grade astrocytic neoplasm",
          "high grade astrocytic tumor",
          "high-grade astrocytic neoplasm",
          "high-grade astrocytic tumor",
          "high-grade astrocytic tumour",
          "high-grade astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma (grade III astrocytic tumor) or glioblastoma (grade IV astrocytic tumor)."
      },
      "child_count": 6,
      "reference_id": "MONDO:0016680"
    },
    {
      "id": 19525,
      "label": "astrocytoma (excluding glioblastoma)",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000272",
          "GARD:0025146",
          "ICDO:9400/3",
          "MEDGEN:438",
          "MESH:D001254",
          "NCIT:C60781",
          "ONCOTREE:ASTR",
          "SCTID:147101000119108",
          "UMLS:C0004114"
        ],
        "synonyms": [
          "astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0019781"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:231373",
          "NCIT:C36025",
          "UMLS:C1332287"
        ],
        "synonyms": [
          "anaplastic malignant neoplasm"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020633"
    }
  ],
  "children": [
    {
      "id": 25201,
      "label": "IDH-mutant anaplastic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080875",
          "GARD:0026601"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma carrying IDH mutations."
      },
      "child_count": 3,
      "reference_id": "MONDO:0850332"
    },
    {
      "id": 25202,
      "label": "IDH-wildtype anaplastic astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080876",
          "GARD:0026602",
          "NCIT:C129291"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma lacking mutations in IDH1 or IDH2 genes."
      },
      "child_count": 0,
      "reference_id": "MONDO:0850333"
    },
    {
      "id": 25259,
      "label": "high-grade astrocytoma with piloid features",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17148
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081304",
          "GARD:0026637",
          "MEDGEN:1812304",
          "NCIT:C185879",
          "UMLS:C5670122"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic astrocytoma that is characterized by high-grade piloid and/or glioblastoma-like histological features. It may occur anywhere in the central nervous system but most often arises in the posterior fossa."
      },
      "child_count": 0,
      "reference_id": "MONDO:0858958"
    }
  ],
  "roots": [
    {
      "id": 17144,
      "label": "high grade astrocytic tumor"
    },
    {
      "id": 19525,
      "label": "astrocytoma (excluding glioblastoma)"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer"
    }
  ]
}