{
  "id": 17149,
  "label": "low-grade astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016685",
  "properties": {
    "xrefs": [
      "GARD:0020706",
      "MEDGEN:727259",
      "MedDRA:10065869",
      "Orphanet:251592",
      "UMLS:C1314694"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ]
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 5,
  "parents": [
    {
      "id": 19525,
      "label": "astrocytoma (excluding glioblastoma)",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0000272",
          "GARD:0025146",
          "ICDO:9400/3",
          "MEDGEN:438",
          "MESH:D001254",
          "NCIT:C60781",
          "ONCOTREE:ASTR",
          "SCTID:147101000119108",
          "UMLS:C0004114"
        ],
        "synonyms": [
          "astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A tumor of the brain or spinal cord showing astrocytic differentiation. It includes the following clinicopathological entities: pilocytic astrocytoma, diffuse astrocytoma, anaplastic astrocytoma, pleomorphic xanthoastrocytoma, and subependymal giant cell astrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0019781"
    },
    {
      "id": 20694,
      "label": "low grade astrocytic tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20692,
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025344",
          "NCIT:C116342"
        ],
        "synonyms": [
          "low grade astrocytic neoplasm",
          "low grade astrocytic tumor",
          "low-grade astrocytic neoplasm",
          "low-grade astrocytic tumor",
          "low-grade astrocytic tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A grade I or grade II astrocytic tumor. This category includes pilocytic astrocytoma (grade I), subependymal giant cell astrocytoma (grade I), and diffuse astrocytoma (grade II)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0021638"
    }
  ],
  "children": [
    {
      "id": 7895,
      "label": "pituicytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4246,
        5133,
        5202,
        17149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081280",
          "EFO:1000477",
          "GARD:0020711",
          "ICD9:237.0",
          "ICDO:9432/1",
          "MEDGEN:458776",
          "NCIT:C94524",
          "ONCOTREE:PTCY",
          "Orphanet:251623",
          "SCTID:608817003",
          "UMLS:C2986550"
        ],
        "synonyms": [
          "pituicytoma",
          "pituicytoma (WHO grade I)",
          "posterior pituitary astrocytoma",
          "PTCY"
        ],
        "categories": [
          {
            "ref": "MONDO:0002081",
            "name": "musculoskeletal system disorder"
          },
          {
            "ref": "MONDO:0003900",
            "name": "connective tissue disorder"
          },
          {
            "ref": "MONDO:0005039",
            "name": "reproductive system disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "An extremely rare, WHO grade I, circumscribed and slow-growing tumor that arises from the neurohypophysis or infundibulum and described in adults. It is characterized by the presence of elongated, spindle-shaped neoplastic glial cells that form storiform patterns or interlacing fascicular arrangements. Signs and symptoms include visual disturbances, headache, amenorrhea, and decreased libido."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006372"
    },
    {
      "id": 17150,
      "label": "diffuse astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4857",
          "GARD:0005907",
          "MEDGEN:83708",
          "NANDO:2200085",
          "NCIT:C7173",
          "ONCOTREE:DASTR",
          "Orphanet:251595",
          "UMLS:C0280785"
        ],
        "synonyms": [
          "WHO grade II astrocytoma",
          "astrocytoma, diffuse",
          "astrocytoma, diffuse, malignant",
          "diffuse astrocytoma",
          "grade II astrocytic neoplasm",
          "grade II astrocytic tumor",
          "grade II astrocytic tumour",
          "grade II astrocytoma",
          "fibrillary astrocytoma (histologic variant)",
          "gemistocytic astrocytoma (histologic variant)",
          "low-grade diffuse astrocytoma",
          "protoplasmic astrocytoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016686"
    },
    {
      "id": 17154,
      "label": "pleomorphic xanthoastrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4852",
          "GARD:0010631",
          "ICDO:9424/3",
          "MEDGEN:137786",
          "NCIT:C4323",
          "ONCOTREE:PXA",
          "Orphanet:251607",
          "UMLS:C0334586"
        ],
        "synonyms": [
          "PXA",
          "pleomorphic Xantho-astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A WHO grade ll astrocytic tumor with a relatively favorable prognosis. It is characterized by pleomorphic and lipidized cells expressing GFAP often surrounded by a reticulin network and eosinophilic granular bodies. It presents in the superficial cerebral hemispheres and involves the meninges. It typically affects children and young adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0016690"
    },
    {
      "id": 17155,
      "label": "pilocytic astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4851",
          "GARD:0009808",
          "ICDO:9421/1",
          "MEDGEN:87271",
          "NANDO:2200084",
          "NCIT:C4047",
          "ONCOTREE:PAST",
          "Orphanet:251612",
          "SCTID:763865009",
          "UMLS:C0334583"
        ],
        "synonyms": [
          "astrocytoma, benign",
          "astrocytoma, pilocytic, benign",
          "grade I astrocytic neoplasm",
          "grade I astrocytic tumor",
          "grade I astrocytic tumour",
          "grade I astrocytoma",
          "pilocytic astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Pilocytic astrocytoma is a rare subtype of low-grade glioma of the central nervous system characterized by a well circumscribed, often cystic, brain tumor with a discrete mural nodule and long, hair-like projections that extend from the neoplastic astrocytes. Depending on the primary localization and the size of the tumor, patients can present with signs of raised intracranial pressure (headache, vomiting, papilledema), blurred vision, decreased visual acuity, ataxia and/or nystagmus, among others. It is most commonly located in the cerebellum, but occurrence in the hypothalamus, brain stem, optic chiasma, and hemispheres has also been reported."
      },
      "child_count": 4,
      "reference_id": "MONDO:0016691"
    },
    {
      "id": 17157,
      "label": "subependymal giant cell astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        9025,
        17149
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5077",
          "GARD:0010632",
          "ICDO:9384/1",
          "MEDGEN:61446",
          "NCIT:C3696",
          "Orphanet:251618",
          "SCTID:449799008",
          "UMLS:C0205768"
        ],
        "synonyms": [
          "SEGA",
          "subependymal giant cell astrocytic neoplasm",
          "subependymal giant cell astrocytic tumor",
          "subependymal giant cell astrocytic tumour",
          "subependymal giant cell astrocytoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign, slowly growing tumor (WHO grade I) typically arising in the wall of the lateral ventricles and composed of large ganglioid astrocytes. It is the most common CNS neoplasm in patients with tuberous sclerosis complex and typically occurs during the first two decades of life. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016693"
    }
  ],
  "roots": [
    {
      "id": 19525,
      "label": "astrocytoma (excluding glioblastoma)"
    },
    {
      "id": 20694,
      "label": "low grade astrocytic tumor"
    }
  ]
}