{
  "id": 17150,
  "label": "diffuse astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016686",
  "properties": {
    "xrefs": [
      "DOID:4857",
      "GARD:0005907",
      "MEDGEN:83708",
      "NANDO:2200085",
      "NCIT:C7173",
      "ONCOTREE:DASTR",
      "Orphanet:251595",
      "UMLS:C0280785"
    ],
    "synonyms": [
      "WHO grade II astrocytoma",
      "astrocytoma, diffuse",
      "astrocytoma, diffuse, malignant",
      "diffuse astrocytoma",
      "grade II astrocytic neoplasm",
      "grade II astrocytic tumor",
      "grade II astrocytic tumour",
      "grade II astrocytoma",
      "fibrillary astrocytoma (histologic variant)",
      "gemistocytic astrocytoma (histologic variant)",
      "low-grade diffuse astrocytoma",
      "protoplasmic astrocytoma (histologic variant)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 4,
  "parents": [
    {
      "id": 17149,
      "label": "low-grade astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19525,
        20694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0020706",
          "MEDGEN:727259",
          "MedDRA:10065869",
          "Orphanet:251592",
          "UMLS:C1314694"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 10,
      "reference_id": "MONDO:0016685"
    },
    {
      "id": 20695,
      "label": "grade II glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025345",
          "MEDGEN:1391502",
          "NCIT:C132505",
          "UMLS:C4330050"
        ],
        "synonyms": [
          "WHO grade II glioma",
          "grade II glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0021639"
    }
  ],
  "children": [
    {
      "id": 17151,
      "label": "protoplasmic astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7008",
          "GARD:0020707",
          "ICDO:9410/3",
          "MEDGEN:87268",
          "NCIT:C4320",
          "Orphanet:251598",
          "UMLS:C0334580"
        ],
        "synonyms": [
          "protoplasmic astrocytic tumour",
          "protoplasmic astrocytoma",
          "protoplasmic astrocytoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016687"
    },
    {
      "id": 17152,
      "label": "fibrillary astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6726",
          "GARD:0020708",
          "ICDO:9420/3",
          "MEDGEN:87270",
          "MedDRA:10065889",
          "NCIT:C4322",
          "Orphanet:251601",
          "UMLS:C0334582"
        ],
        "synonyms": [
          "fibrillary astrocytic tumours",
          "fibrillary astrocytoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "The most frequent histological variant of diffuse astrocytoma. It is predominantly composed of fibrillary neoplastic astrocytes. Nuclear atypia is a diagnostic criterion but mitotic activity, necrosis and microvascular proliferation are absent. The occasional or regional occurrence of gemistocytic neoplastic cells is compatible with the diagnosis of fibrillary astrocytoma. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016688"
    },
    {
      "id": 17153,
      "label": "gemistocytic astrocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7005",
          "GARD:0020709",
          "ICDO:9411/3",
          "MEDGEN:87269",
          "NCIT:C4321",
          "Orphanet:251604",
          "UMLS:C0334581"
        ],
        "synonyms": [
          "Gemistocytoma",
          "gemistocytic astrocytic tumour",
          "gemistocytic astrocytoma",
          "gemistocytic astrocytoma (morphologic abnormality)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0016689"
    },
    {
      "id": 25553,
      "label": "diffuse astrocytoma, MYB- or MYBL1-altered",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17150
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0081279",
          "GARD:0026758"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A diffuse astrocytoma that is a diffusely infiltrative astroglial neoplasm composed of monomorphic cells with genetic alterations in MYB or MYBL1."
      },
      "child_count": 0,
      "reference_id": "MONDO:0859615"
    }
  ],
  "roots": [
    {
      "id": 17149,
      "label": "low-grade astrocytoma"
    },
    {
      "id": 20695,
      "label": "grade II glioma"
    }
  ]
}