{
  "id": 17151,
  "label": "protoplasmic astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016687",
  "properties": {
    "xrefs": [
      "DOID:7008",
      "GARD:0020707",
      "ICDO:9410/3",
      "MEDGEN:87268",
      "NCIT:C4320",
      "Orphanet:251598",
      "UMLS:C0334580"
    ],
    "synonyms": [
      "protoplasmic astrocytic tumour",
      "protoplasmic astrocytoma",
      "protoplasmic astrocytoma (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare variant of diffuse astrocytoma. It is predominantly composed of neoplastic astrocytes showing a small cell body with few, flaccid processes with a low content of glial filaments and scant GFAP expression. This lesion is not well defined and is considered by some authors as an occasional histopathological feature rather than a reproducibly identifiable variant. When occurring in children, this neoplasm may be difficult to separate from pilocytic juvenile astrocytoma. (Adapted from WHO)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4857",
          "GARD:0005907",
          "MEDGEN:83708",
          "NANDO:2200085",
          "NCIT:C7173",
          "ONCOTREE:DASTR",
          "Orphanet:251595",
          "UMLS:C0280785"
        ],
        "synonyms": [
          "WHO grade II astrocytoma",
          "astrocytoma, diffuse",
          "astrocytoma, diffuse, malignant",
          "diffuse astrocytoma",
          "grade II astrocytic neoplasm",
          "grade II astrocytic tumor",
          "grade II astrocytic tumour",
          "grade II astrocytoma",
          "fibrillary astrocytoma (histologic variant)",
          "gemistocytic astrocytoma (histologic variant)",
          "low-grade diffuse astrocytoma",
          "protoplasmic astrocytoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016686"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma"
    }
  ]
}