{
  "id": 17153,
  "label": "gemistocytic astrocytoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016689",
  "properties": {
    "xrefs": [
      "DOID:7005",
      "GARD:0020709",
      "ICDO:9411/3",
      "MEDGEN:87269",
      "NCIT:C4321",
      "Orphanet:251604",
      "UMLS:C0334581"
    ],
    "synonyms": [
      "Gemistocytoma",
      "gemistocytic astrocytic tumour",
      "gemistocytic astrocytoma",
      "gemistocytic astrocytoma (morphologic abnormality)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A rare variant of diffuse astrocytoma. It is characterized by the presence of a conspicuous, though variable, fraction of gemistocytic neoplastic astrocytes. Gemistocytes are round to oval astrocytes with abundant, glassy, non-fibrillary cytoplasm which appears to displace the dark, angulated nucleus to the periphery of the cell. To make the diagnosis of gemistocytic astrocytoma, gemistocytes should amount to more than approximately 20% of all tumor cells. (Adapted from WHO)"
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17149,
        20695
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4857",
          "GARD:0005907",
          "MEDGEN:83708",
          "NANDO:2200085",
          "NCIT:C7173",
          "ONCOTREE:DASTR",
          "Orphanet:251595",
          "UMLS:C0280785"
        ],
        "synonyms": [
          "WHO grade II astrocytoma",
          "astrocytoma, diffuse",
          "astrocytoma, diffuse, malignant",
          "diffuse astrocytoma",
          "grade II astrocytic neoplasm",
          "grade II astrocytic tumor",
          "grade II astrocytic tumour",
          "grade II astrocytoma",
          "fibrillary astrocytoma (histologic variant)",
          "gemistocytic astrocytoma (histologic variant)",
          "low-grade diffuse astrocytoma",
          "protoplasmic astrocytoma (histologic variant)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A low-grade (WHO grade II) astrocytic neoplasm. It is characterized by diffuse infiltration of neighboring central nervous system structures. These lesions typically affect young adults and have a tendency for progression to anaplastic astrocytoma and glioblastoma. Based on the IDH genes mutation status, diffuse astrocytomas are classified as IDH-mutant, IDH-wildtype, and not otherwise specified."
      },
      "child_count": 8,
      "reference_id": "MONDO:0016686"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17150,
      "label": "diffuse astrocytoma"
    }
  ]
}