{
  "id": 17159,
  "label": "anaplastic oligodendroglioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016696",
  "properties": {
    "xrefs": [
      "DOID:7154",
      "EFO:0002501",
      "GARD:0009472",
      "ICDO:9451/3",
      "MEDGEN:90812",
      "MedDRA:10026659",
      "NCIT:C4326",
      "ONCOTREE:AODG",
      "Orphanet:251630",
      "UMLS:C0334590"
    ],
    "synonyms": [
      "WHO grade III oligodendroglial neoplasm",
      "WHO grade III oligodendroglial tumor",
      "WHO grade III oligodendroglial tumour",
      "anaplastic oligodendroglioma",
      "malignant oligodendroglioma",
      "oligodendroglioma, anaplastic, malignant",
      "oligodendroglioma, malignant",
      "undifferentiated oligodendroglioma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A WHO grade III oligodendroglioma with focal or diffuse malignant morphologic features (prominent nuclear pleomorphism, mitoses, and increased cellularity)."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 1,
  "parents": [
    {
      "id": 18713,
      "label": "oligodendroglial tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0013156",
          "MEDGEN:233266",
          "NCIT:C6960",
          "Orphanet:46484",
          "UMLS:C1335110"
        ],
        "synonyms": [
          "oligodendroglial neoplasm",
          "oligodendroglial tumor"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Oligodendrogliomas are cerebral tumors that are differentiated from other gliomas on the basis of their unique genetic characteristics and better response to chemotherapy. These tumors are classified according to their grade (low grade oligodendrogliomas: grade II of the WHO classification and anaplastic oligodendrogliomas: grade III of the WHO classification) and according to their pure or mixed histology (oligoastrocytomas)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0018744"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:231373",
          "NCIT:C36025",
          "UMLS:C1332287"
        ],
        "synonyms": [
          "anaplastic malignant neoplasm"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020633"
    },
    {
      "id": 20696,
      "label": "grade III glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025346",
          "MEDGEN:925529",
          "NCIT:C127816",
          "UMLS:C4287997"
        ],
        "synonyms": [
          "WHO grade III glioma",
          "anaplastic glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021640"
    }
  ],
  "children": [
    {
      "id": 25549,
      "label": "IDH-mutant and 1p/19q-codeleted oligodendroglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17159
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080882",
          "GARD:0026754",
          "MEDGEN:926090",
          "NCIT:C129318",
          "UMLS:C4288558"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic oligodendroglioma that has material basis in IDH gene family mutation and combined whole-arm losses of 1p and 19q (1p/19q codeletion)."
      },
      "child_count": 2,
      "reference_id": "MONDO:0859592"
    }
  ],
  "roots": [
    {
      "id": 18713,
      "label": "oligodendroglial tumor"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer"
    },
    {
      "id": 20696,
      "label": "grade III glioma"
    }
  ]
}