{
  "id": 17161,
  "label": "ependymoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016698",
  "properties": {
    "xrefs": [
      "DOID:4844",
      "EFO:1000028",
      "GARD:0006353",
      "ICDO:9391/3",
      "MEDGEN:41825",
      "MESH:D004806",
      "MedDRA:10014967",
      "NANDO:2200088",
      "NCIT:C3017",
      "ONCOTREE:EPM",
      "Orphanet:251636",
      "UMLS:C0014474"
    ],
    "synonyms": [
      "benign ependymoma",
      "ependymoma",
      "WHO grade II ependymal neoplasm",
      "WHO grade II ependymal tumor",
      "WHO grade II ependymal tumour",
      "ependymoma, benign",
      "clear cell ependymoma (histologic variant)",
      "ependymoma, familial",
      "papillary ependymoma (histologic variant)",
      "tanycytic ependymoma (histologic variant)"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A WHO grade II, slow growing tumor of children and young adults, usually located intraventricularly. It is the most common ependymal neoplasm. It often causes clinical symptoms by blocking cerebrospinal fluid pathways. Key histological features include perivascular pseudorosettes and ependymal rosettes. (WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 8,
  "parents": [
    {
      "id": 5210,
      "label": "ependymal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000027",
          "GARD:0016527",
          "MEDGEN:232459",
          "NCIT:C6770",
          "ONCOTREE:EPMT",
          "Orphanet:301",
          "UMLS:C1333407"
        ],
        "synonyms": [
          "ependymal neoplasm",
          "ependymal tumor",
          "ependymal tumors",
          "ependymal tumours",
          "ependymomal tumor",
          "ependymomal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003266"
    },
    {
      "id": 20695,
      "label": "grade II glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20693
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025345",
          "MEDGEN:1391502",
          "NCIT:C132505",
          "UMLS:C4330050"
        ],
        "synonyms": [
          "WHO grade II glioma",
          "grade II glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A glioma arising from the central nervous system. This category includes diffuse astrocytoma, ependymoma, oligodendroglioma, and oligoastrocytoma."
      },
      "child_count": 5,
      "reference_id": "MONDO:0021639"
    }
  ],
  "children": [
    {
      "id": 5392,
      "label": "cellular ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5500",
          "GARD:0023517",
          "MEDGEN:235137",
          "NCIT:C4713",
          "UMLS:C1384403"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma which shows conspicuous cellularity without a significant increase in mitotic rate. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003470"
    },
    {
      "id": 5395,
      "label": "spinal cord ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17161,
        20661
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5503",
          "GARD:0023518",
          "MEDGEN:65968",
          "NCIT:C3875",
          "SCTID:254949006",
          "UMLS:C0238432"
        ],
        "synonyms": [
          "ependymoma of spinal cord",
          "ependymoma of the spinal cord",
          "spinal cord ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma that arises from the spinal cord."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003473"
    },
    {
      "id": 5396,
      "label": "tanycytic ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5504",
          "GARD:0023519",
          "MEDGEN:237159",
          "NCIT:C6903",
          "UMLS:C1370500"
        ],
        "synonyms": [
          "tanycytic ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A variant of ependymoma, often found in the spinal cord, with tumor cells arranged in fascicles of variable width and cell density. Ependymal rosettes are generally absent, so this lesion must be distinguished from astrocytic neoplasms, but its EM characteristics are ependymal. (Adapted from WHO.)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003474"
    },
    {
      "id": 5397,
      "label": "papillary ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5505",
          "GARD:0023520",
          "ICDO:9393/3",
          "MEDGEN:90810",
          "NCIT:C4319",
          "UMLS:C0334578"
        ],
        "synonyms": [
          "papillary ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A rare variant of ependymoma characterized by well formed papillae. Tumor cell processes abutting capillaries are usually GFAP-positive. Differential diagnoses include choroid plexus papilloma, papillary meningioma and metastatic papillary carcinoma. (Adapted from WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0003475"
    },
    {
      "id": 5398,
      "label": "clear cell ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5507",
          "GARD:0023521",
          "MEDGEN:1852795",
          "NCIT:C4714",
          "ONCOTREE:CCE",
          "UMLS:C5848299"
        ],
        "synonyms": [
          "clear cell ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma, often supratentorial in location, characterized by the presence of ependymal cells with a perinuclear halo."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003476"
    },
    {
      "id": 5399,
      "label": "brain stem ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4918,
        6066,
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5508",
          "GARD:0023522",
          "MEDGEN:231459",
          "NCIT:C5098",
          "UMLS:C1332609"
        ],
        "synonyms": [
          "brain stem ependymoma",
          "brainstem ependymoma",
          "ependymoma of brain stem",
          "ependymoma of brainstem",
          "ependymoma of the brain stem"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma that arises from the brain stem."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003477"
    },
    {
      "id": 5400,
      "label": "childhood ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17161,
        20320
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5509",
          "GARD:0023523",
          "MEDGEN:343609",
          "MESH:C531673",
          "NCIT:C8578",
          "UMLS:C1851584"
        ],
        "synonyms": [
          "ependymoma",
          "childhood ependymoma",
          "ependymoma of childhood",
          "paediatric ependymoma",
          "pediatric ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An ependymoma that arises from the central nervous system and occurs during childhood."
      },
      "child_count": 2,
      "reference_id": "MONDO:0003478"
    },
    {
      "id": 17160,
      "label": "low grade ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17161
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "Orphanet:251633",
          "icd11.foundation:641455939"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ]
      },
      "child_count": 1,
      "reference_id": "MONDO:0016697"
    }
  ],
  "roots": [
    {
      "id": 5210,
      "label": "ependymal tumor"
    },
    {
      "id": 20695,
      "label": "grade II glioma"
    }
  ]
}