{
  "id": 17163,
  "label": "anaplastic ependymoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016700",
  "properties": {
    "xrefs": [
      "DOID:5074",
      "DOID:5889",
      "GARD:0010634",
      "ICDO:9392/3",
      "MEDGEN:128891",
      "MedDRA:10014968",
      "NCIT:C4049",
      "ONCOTREE:APE",
      "Orphanet:251646",
      "UMLS:C0280788"
    ],
    "synonyms": [
      "ependymal tumors",
      "ependymal tumours",
      "WHO grade III ependymal neoplasm",
      "WHO grade III ependymal tumor",
      "WHO grade III ependymal tumour",
      "anaplastic ependymal neoplasm",
      "anaplastic ependymal tumor",
      "anaplastic ependymal tumour",
      "anaplastic ependymoma",
      "ependymoma, anaplastic, malignant",
      "ependymoma, malignant",
      "high-grade ependymoma",
      "malignant ependymoma",
      "undifferentiated ependymal neoplasm",
      "undifferentiated ependymal tumor",
      "undifferentiated ependymal tumour",
      "undifferentiated ependymoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Anaplastic ependymoma is a rare, malignant type of ependymoma that most often arises in the supratentorial region of the brain of children and young adults and that manifests with variable symptoms including headaches, nausea, vision impairment, memory loss and difficulty walking."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5210,
      "label": "ependymal tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        20287
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000027",
          "GARD:0016527",
          "MEDGEN:232459",
          "NCIT:C6770",
          "ONCOTREE:EPMT",
          "Orphanet:301",
          "UMLS:C1333407"
        ],
        "synonyms": [
          "ependymal neoplasm",
          "ependymal tumor",
          "ependymal tumors",
          "ependymal tumours",
          "ependymomal tumor",
          "ependymomal tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of neoplasms which arise from the ependymal lining of the cerebral ventricles and from the remnants of the central canal of the spinal cord. Ependymal tumors occur predominantly in children and young adults with varied morphological features and biological behavior. There are 4 types: ependymoma, anaplastic ependymoma, myxopapillary ependymoma and subependymoma. (WHO)"
      },
      "child_count": 6,
      "reference_id": "MONDO:0003266"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6733
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:231373",
          "NCIT:C36025",
          "UMLS:C1332287"
        ],
        "synonyms": [
          "anaplastic malignant neoplasm"
        ]
      },
      "child_count": 8,
      "reference_id": "MONDO:0020633"
    },
    {
      "id": 20696,
      "label": "grade III glioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        24071
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025346",
          "MEDGEN:925529",
          "NCIT:C127816",
          "UMLS:C4287997"
        ],
        "synonyms": [
          "WHO grade III glioma",
          "anaplastic glioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A group of malignant gliomas that includes anaplastic astrocytoma, anaplastic oligodendroglioma, anaplastic oligoastrocytoma, and anaplastic ependymoma."
      },
      "child_count": 3,
      "reference_id": "MONDO:0021640"
    }
  ],
  "children": [
    {
      "id": 5574,
      "label": "adult anaplastic ependymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17163
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5890",
          "GARD:0023619",
          "MEDGEN:83709",
          "NCIT:C8269",
          "UMLS:C0280787"
        ],
        "synonyms": [
          "anaplastic ependymoma",
          "adult anaplastic ependymoma",
          "adult malignant ependymoma",
          "anaplastic ependymoma of adults",
          "malignant adult ependymoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An anaplastic ependymoma occurring in adults."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003690"
    },
    {
      "id": 25205,
      "label": "posterior fossa ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17163
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080889",
          "GARD:0026605",
          "MEDGEN:1811888",
          "NCIT:C186443",
          "UMLS:C5670542"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A high grade ependymoma that is located within the posterior fossa."
      },
      "child_count": 2,
      "reference_id": "MONDO:0850339"
    },
    {
      "id": 25206,
      "label": "supratentorial ependymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        17163
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0080890",
          "GARD:0026606",
          "MEDGEN:1811811",
          "NCIT:C186343",
          "UMLS:C5670470"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A high grade ependymoma that is located within the supratentorial brain."
      },
      "child_count": 3,
      "reference_id": "MONDO:0850340"
    }
  ],
  "roots": [
    {
      "id": 5210,
      "label": "ependymal tumor"
    },
    {
      "id": 20048,
      "label": "anaplastic cancer"
    },
    {
      "id": 20696,
      "label": "grade III glioma"
    }
  ]
}