{
  "id": 17190,
  "label": "choriocarcinoma of the central nervous system",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016740",
  "properties": {
    "xrefs": [
      "GARD:0020734",
      "MEDGEN:234100",
      "NCIT:C7012",
      "Orphanet:252015",
      "UMLS:C1332876",
      "icd11.foundation:511691786"
    ],
    "synonyms": [
      "central nervous system choriocarcinoma",
      "central nervous system choriocarcinoma (disease)",
      "choriocarcinoma of CNS",
      "choriocarcinoma of the CNS"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A malignant germ cell tumor of the central nervous system characterized by extra-embryonic differentiation along trophoblastic lines. The diagnosis requires the identification of cytotrophoblastic elements, as well as syncytiotrophoblastic giant cells. (WHO)"
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 4753,
      "label": "central nervous system cancer",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7479,
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3620",
          "EFO:0000326",
          "GARD:0027614",
          "ICD9:239.7",
          "MEDGEN:87593",
          "MESH:D016543",
          "NANDO:2100007",
          "NCIT:C4627",
          "SCTID:126951006",
          "UMLS:C0348374"
        ],
        "synonyms": [
          "CNS neoplasm",
          "central nervous system tumor",
          "central nervous system tumour",
          "CNS cancer",
          "CNS malignant neoplasms",
          "CNS neoplasms, malignant",
          "cancer of CNS",
          "cancer of central nervous system",
          "cancer of the CNS",
          "cancer of the central nervous system",
          "central nervous system cancer",
          "central nervous system neoplasms, malignant",
          "central nervous system tumours",
          "malignant CNS neoplasm",
          "malignant CNS neoplasms",
          "malignant CNS tumor",
          "malignant CNS tumour",
          "malignant central nervous system neoplasm",
          "malignant central nervous system tumor",
          "malignant central nervous system tumour",
          "malignant neoplasm of CNS",
          "malignant neoplasm of central nervous system",
          "malignant neoplasm of the CNS",
          "malignant neoplasm of the central nervous system",
          "malignant tumor of CNS",
          "malignant tumor of central nervous system",
          "malignant tumor of the CNS",
          "malignant tumor of the central nervous system",
          "malignant tumour of CNS",
          "malignant tumour of central nervous system",
          "malignant tumour of the CNS",
          "malignant tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A malignant neoplasm involving the central nervous system"
      },
      "child_count": 40,
      "reference_id": "MONDO:0002714"
    },
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5094,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5677",
          "GARD:0023567",
          "MEDGEN:233662",
          "NCIT:C8885",
          "UMLS:C1334582"
        ],
        "synonyms": [
          "cancer of extragonadal non-seminomatous germ cell",
          "cancer of the extragonadal non-seminomatous germ cell",
          "extragonadal non-seminomatous germ cell cancer",
          "extragonadal primary Nonseminoma",
          "malignant extragonadal Nonseminoma",
          "malignant extragonadal non-seminomatous germ cell neoplasm",
          "malignant extragonadal non-seminomatous germ cell tumor",
          "malignant extragonadal non-seminomatous germ cell tumour",
          "malignant neoplasm of extragonadal non-seminomatous germ cell",
          "malignant neoplasm of the extragonadal non-seminomatous germ cell",
          "malignant tumor of extragonadal non-seminomatous germ cell",
          "malignant tumor of the extragonadal non-seminomatous germ cell",
          "malignant tumour of extragonadal non-seminomatous germ cell",
          "malignant tumour of the extragonadal non-seminomatous germ cell",
          "primary malignant extragonadal Nonseminoma"
        ],
        "definition": "A malignant non-seminomatous germ cell tumor that develops as a primary tumor in an anatomic site other than the testis or ovary."
      },
      "child_count": 20,
      "reference_id": "MONDO:0003578"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4886,
        6773
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3594",
          "EFO:0002893",
          "GARD:0006059",
          "HP:0100768",
          "ICDO:9100/3",
          "MEDGEN:40278",
          "MESH:D002822",
          "NANDO:2200070",
          "NCIT:C2948",
          "ONCOTREE:BCCA",
          "SCTID:188188009",
          "UMLS:C0008497"
        ],
        "synonyms": [
          "chorioblastoma",
          "choriocarcinoma",
          "choriocarcinoma (disease)",
          "choriocarcinoma, malignant",
          "chorioepithelioma",
          "chorion carcinoma",
          "chorionic carcinoma"
        ],
        "definition": "An aggressive malignant tumor arising from trophoblastic cells. The vast majority of cases arise in the uterus and represent gestational choriocarcinomas that derive from placental trophoblastic cells. Approximately half of the cases develop from a complete hydatidiform mole. A minority of cases arise in the testis or the ovaries. There is often marked elevation of human chorionic gonadotropin (hCG) in the blood. Choriocarcinomas disseminate rapidly through the hematogenous route; the lungs are most frequently affected."
      },
      "child_count": 16,
      "reference_id": "MONDO:0005207"
    },
    {
      "id": 20012,
      "label": "central nervous system nongerminomatous germ cell tumor",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4999,
        19983
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025171",
          "MEDGEN:760465",
          "NCIT:C100093",
          "UMLS:C1696109"
        ],
        "synonyms": [
          "central nervous system nongerminomatous germ cell tumor",
          "nongerminomatous GCT - CNS",
          "nongerminomatous germ cell tumor of the CNS",
          "nongerminomatous germ cell tumour of the CNS"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Germ cell tumors of the central nervous system other than germinoma. This category includes teratoma, choriocarcinoma, embryonal carcinoma, and yolk sac tumor."
      },
      "child_count": 8,
      "reference_id": "MONDO:0020574"
    }
  ],
  "children": [
    {
      "id": 5423,
      "label": "pineal region choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4216,
        17190
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5553",
          "GARD:0023538",
          "MEDGEN:233327",
          "NCIT:C6759",
          "UMLS:C1335414"
        ],
        "synonyms": [
          "choriocarcinoma of pineal area",
          "choriocarcinoma of pineal region",
          "choriocarcinoma of the pineal area",
          "choriocarcinoma of the pineal region",
          "pineal area choriocarcinoma",
          "pineal choriocarcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A choriocarcinoma (disease) that involves the pineal body."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003509"
    },
    {
      "id": 5810,
      "label": "adult central nervous system choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5337,
        17190
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6634",
          "GARD:0023749",
          "MEDGEN:234582",
          "NCIT:C5793",
          "UMLS:C1370505"
        ],
        "synonyms": [
          "central nervous system choriocarcinoma",
          "adult CNS choriocarcinoma",
          "adult central nervous system choriocarcinoma",
          "adult choriocarcinoma of the central nervous system",
          "choriocarcinoma of adult CNS",
          "choriocarcinoma of adult central nervous system",
          "choriocarcinoma of the adult CNS",
          "choriocarcinoma of the adult central nervous system",
          "choriocarcinoma of the central nervous system of adults"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A choriocarcinoma of the central nervous system that occurs in an adult."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003952"
    },
    {
      "id": 5811,
      "label": "pediatric CNS choriocarcinoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5630,
        6283,
        17190
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6639",
          "GARD:0023750",
          "MEDGEN:234603",
          "NCIT:C6206",
          "UMLS:C1377604"
        ],
        "synonyms": [
          "Central nervous system choriocarcinoma",
          "childhood CNS choriocarcinoma",
          "childhood central nervous system choriocarcinoma",
          "childhood choriocarcinoma of the central nervous system",
          "choriocarcinoma of childhood CNS",
          "choriocarcinoma of childhood central nervous system",
          "choriocarcinoma of paediatric CNS",
          "choriocarcinoma of paediatric central nervous system",
          "choriocarcinoma of pediatric CNS",
          "choriocarcinoma of pediatric central nervous system",
          "choriocarcinoma of the central nervous system of childhood",
          "choriocarcinoma of the childhood CNS",
          "choriocarcinoma of the childhood central nervous system",
          "choriocarcinoma of the paediatric CNS",
          "choriocarcinoma of the pediatric CNS",
          "choriocarcinoma of the pediatric central nervous system",
          "paediatric central nervous system choriocarcinoma",
          "paediatric choriocarcinoma of the central nervous system",
          "pediatric central nervous system choriocarcinoma",
          "pediatric choriocarcinoma of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A choriocarcinoma that arises from the central nervous system and occurs during childhood."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003953"
    }
  ],
  "roots": [
    {
      "id": 4753,
      "label": "central nervous system cancer"
    },
    {
      "id": 5475,
      "label": "extragonadal nonseminomatous germ cell tumor"
    },
    {
      "id": 6924,
      "label": "choriocarcinoma"
    },
    {
      "id": 20012,
      "label": "central nervous system nongerminomatous germ cell tumor"
    }
  ]
}