{ "id": 17192, "label": "tumor of meninges", "model": { "label": "Mondo Disease Ontology (MONDO)", "source": 0 }, "type_id": 0, "reference_id": "MONDO:0016743", "properties": { "xrefs": [ "EFO:0003851", "GARD:0020737", "ICD9:239.7", "MEDGEN:44353", "MedDRA:10061282", "NCIT:C3229", "ONCOTREE:MNGT", "Orphanet:252025", "SCTID:126965008", "UMLS:C0025284" ], "synonyms": [ "meningeal cluster neoplasm", "meningeal cluster neoplasm (disease)", "meningeal cluster rare nervous system tumor", "meningeal cluster rare nervous system tumour", "meningeal cluster tumor", "meningeal cluster tumour", "meningeal neoplasm", "meningeal neoplasms", "meningeal tumor", "meningeal tumour", "meninges neoplasm", "meninges tumor", "meninges tumour", "neoplasm of meningeal cluster", "neoplasm of meninges", "neoplasm of the meninges", "tumor of meningeal cluster", "tumor of meninges", "tumor of the meninges", "tumour of meningeal cluster", "tumour of the meninges", "meningothelial tumor", "meningothelial tumour" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions." }, "isLeaf": false, "isRoot": false, "child_count": 5, "parents": [ { "id": 7694, "label": "central nervous system neoplasm", "isLeaf": false, "isRoot": false, "parents": [ 4657, 20456 ], "type_id": 0, "properties": { "xrefs": [ "EFO:1000158", "MEDGEN:88335", "NCIT:C9293", "UMLS:C0085136" ], "synonyms": [ "CNS neoplasm", "CNS tumor", "CNS tumour", "brain/spinal cord tumor", "brain/spinal cord tumour", "central nervous system neoplasm", "central nervous system neoplasm (disease)", "central nervous system tumor", "central nervous system tumour", "neoplasm of CNS", "neoplasm of central nervous system", "neoplasm of the central nervous system", "tumor of CNS", "tumor of central nervous system", "tumor of the CNS", "tumor of the central nervous system", "tumour of CNS", "tumour of central nervous system", "tumour of the CNS", "tumour of the central nervous system" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign or malignant, primary or metastatic neoplasm that affects the brain, meninges, or spinal cord. Representative examples of primary neoplasms include astrocytoma, oligodendroglioma, ependymoma, and meningioma. Representative examples of metastatic neoplasms include carcinoma and leukemia." }, "child_count": 20, "reference_id": "MONDO:0006130" } ], "children": [ { "id": 17113, "label": "meningioma", "isLeaf": false, "isRoot": false, "parents": [ 17192 ], "type_id": 0, "properties": { "xrefs": [ "DOID:3565", "GARD:0007015", "HP:0002858", "ICDO:9530/0", "MEDGEN:7532", "MESH:D008579", "MedDRA:10027191", "NANDO:2200094", "NCIT:C3230", "NORD:1434", "ONCOTREE:MNG", "Orphanet:2495", "SCTID:302820008", "UMLS:C0025286", "icd11.foundation:672106711" ], "synonyms": [ "meningioma", "meningioma (disease)", "intracranial meningioma", "meningeal neoplasm", "meningothelial cell tumor", "meningothelial cell tumour", "primary meningeal tumor", "primary meningeal tumour", "supratentorial meningioma" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A generally slow growing tumor attached to the dura mater. It is composed of neoplastic meningothelial (arachnoidal) cells. It typically occurs in adults, often women and it has a wide range of histopathological appearances. Of the various subtypes, meningothelial, fibrous and transitional meningiomas are the most common. Most meningiomas are WHO grade I tumors, and some are WHO grade II or III tumors. Most subtypes share a common clinical behavior, although some subtypes are more likely to recur and follow a more aggressive clinical course. (Adapted from WHO)" }, "child_count": 37, "reference_id": "MONDO:0016642" }, { "id": 17193, "label": "diffuse leptomeningeal melanocytosis", "isLeaf": true, "isRoot": false, "parents": [ 17192 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0020739", "MEDGEN:1651380", "Orphanet:252031", "UMLS:C4749348" ], "synonyms": [ "leptomeningeal melanomatosis", "DLM" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Diffuse leptomeningeal melanocytosis is a rare tumor of meninges arising from leptomeningeal melanocytes, characterized by diffuse infiltration of the leptomeninges (pia mater and arachnoidea) anywhere in the central nervous system. Clinical features may include stillbirth, intracranial hypertension and hydrocephalus, seizure, ataxia, syringomyelia, cranial nerve palsy, intracranial hemorrhage, sphincter dysfunction and neuropsychiatric symptoms. Transformation into malignant melanoma of the central nervous system was reported. It may be associated with congenital nevi, as a part of neurocutaneous melanosis." }, "child_count": 0, "reference_id": "MONDO:0016745" }, { "id": 17406, "label": "familial multiple meningioma", "isLeaf": true, "isRoot": false, "parents": [ 17192 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0017260", "MEDGEN:1644853", "Orphanet:263662", "UMLS:C4707361", "icd11.foundation:160795085" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "Familial multiple meningioma is a rare, benign neoplasm of the central nervous system characterized by the development of multiple or, rarely, solitary meningiomas in two or more blood relatives, without other apparent syndromic manifestations. Depending on the localization, growth rate and size of the tumors, patients can present with subtle, gradually worsening or abrupt and severe neurological compromise or can be completely asymptomatic." }, "child_count": 0, "reference_id": "MONDO:0016995" }, { "id": 20501, "label": "malignant tumor of meninges", "isLeaf": false, "isRoot": false, "parents": [ 4753, 17192 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025313", "ICD10CM:C70", "MEDGEN:87594", "NCIT:C4628", "SCTID:363497007", "UMLS:C0348375" ], "synonyms": [ "cancer of meningeal cluster", "cancer of meninges", "cancer of the meninges", "malignant meningeal cluster neoplasm", "malignant meningeal neoplasms", "malignant meningeal tumor", "malignant meningeal tumour", "malignant meninges neoplasm", "malignant meninges tumor", "malignant meninges tumour", "malignant neoplasm of meningeal cluster", "malignant neoplasm of meninges", "malignant neoplasm of the meninges", "malignant neoplasms of meninges", "malignant tumor of the meninges", "malignant tumour of the meninges", "meningeal cancer", "meningeal cluster cancer", "meningeal tumors, malignant" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A cancer that involves the meningeal cluster." }, "child_count": 20, "reference_id": "MONDO:0021322" }, { "id": 20644, "label": "benign neoplasm of meninges", "isLeaf": false, "isRoot": false, "parents": [ 3033, 17192 ], "type_id": 0, "properties": { "xrefs": [ "GARD:0025330", "ICD10CM:D32", "ICD10WHO:D32", "MEDGEN:138093", "NCIT:C4957", "SCTID:109913001", "UMLS:C0348426" ], "synonyms": [ "benign meningeal neoplasm", "benign meningeal neoplasms", "benign meningeal tumor", "benign meningeal tumors", "benign meningeal tumour", "benign meningeal tumours", "benign meninges neoplasm", "benign meninges tumor", "benign meninges tumour", "benign neoplasm of the meninges", "benign neoplasms of meninges", "benign neoplasms of the meninges", "benign tumor of meninges", "benign tumor of the meninges", "benign tumour of meninges", "benign tumour of the meninges", "meningeal cluster benign neoplasm", "meningeal tumors, benign" ], "categories": [ { "ref": "MONDO:0005071", "name": "nervous system disorder" } ], "definition": "A benign neoplasm that involves the meningeal cluster." }, "child_count": 2, "reference_id": "MONDO:0021527" } ], "roots": [ { "id": 7694, "label": "central nervous system neoplasm" } ] }