{
  "id": 17193,
  "label": "diffuse leptomeningeal melanocytosis",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016745",
  "properties": {
    "xrefs": [
      "GARD:0020739",
      "MEDGEN:1651380",
      "Orphanet:252031",
      "UMLS:C4749348"
    ],
    "synonyms": [
      "leptomeningeal melanomatosis",
      "DLM"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Diffuse leptomeningeal melanocytosis is a rare tumor of meninges arising from leptomeningeal melanocytes, characterized by diffuse infiltration of the leptomeninges (pia mater and arachnoidea) anywhere in the central nervous system. Clinical features may include stillbirth, intracranial hypertension and hydrocephalus, seizure, ataxia, syringomyelia, cranial nerve palsy, intracranial hemorrhage, sphincter dysfunction and neuropsychiatric symptoms. Transformation into malignant melanoma of the central nervous system was reported. It may be associated with congenital nevi, as a part of neurocutaneous melanosis."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 17192,
      "label": "tumor of meninges",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7694
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:0003851",
          "GARD:0020737",
          "ICD9:239.7",
          "MEDGEN:44353",
          "MedDRA:10061282",
          "NCIT:C3229",
          "ONCOTREE:MNGT",
          "Orphanet:252025",
          "SCTID:126965008",
          "UMLS:C0025284"
        ],
        "synonyms": [
          "meningeal cluster neoplasm",
          "meningeal cluster neoplasm (disease)",
          "meningeal cluster rare nervous system tumor",
          "meningeal cluster rare nervous system tumour",
          "meningeal cluster tumor",
          "meningeal cluster tumour",
          "meningeal neoplasm",
          "meningeal neoplasms",
          "meningeal tumor",
          "meningeal tumour",
          "meninges neoplasm",
          "meninges tumor",
          "meninges tumour",
          "neoplasm of meningeal cluster",
          "neoplasm of meninges",
          "neoplasm of the meninges",
          "tumor of meningeal cluster",
          "tumor of meninges",
          "tumor of the meninges",
          "tumour of meningeal cluster",
          "tumour of the meninges",
          "meningothelial tumor",
          "meningothelial tumour"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm that affects the meninges. The majority of the neoplasms arise from meningothelial cells and are called meningiomas. Non-meningothelial cell neoplasms include mesenchymal, non-meningothelial tumors, hemangiopericytomas, and melanocytic lesions."
      },
      "child_count": 5,
      "reference_id": "MONDO:0016743"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 17192,
      "label": "tumor of meninges"
    }
  ]
}