{
  "id": 17195,
  "label": "primary melanoma of the central nervous system",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016747",
  "properties": {
    "xrefs": [
      "GARD:0012016",
      "MEDGEN:578849",
      "NCIT:C5505",
      "ONCOTREE:PCNSM",
      "Orphanet:252050",
      "UMLS:C0349626",
      "icd11.foundation:539210076"
    ],
    "synonyms": [
      "CNS melanoma",
      "Central nervous system melanoma",
      "central nervous system melanoma",
      "central nervous system melanoma (disease)",
      "melanoma (disease) of central nervous system",
      "melanoma of CNS",
      "melanoma of central nervous system",
      "melanoma of the CNS",
      "melanoma of the Central nervous system",
      "malignant melanoma of meninges",
      "primary CNS melanoma",
      "primary melanoma of the CNS",
      "primary meningeal melanoma"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "A melanoma that affects the central nervous system. It is characterized by pleomorphism, melanin pigmentation, a high mitotic rate, necrosis, and hemorrhage. It is a highly aggressive and radioresistant tumor. The prognosis is usually poor."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 5175,
      "label": "central nervous system melanocytic neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4753,
        20380
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:4955",
          "GARD:0009422",
          "MEDGEN:1809168",
          "NCIT:C5504",
          "SCTID:277523004",
          "UMLS:C5670969"
        ],
        "synonyms": [
          "CNS melanocytic neoplasm",
          "CNS melanocytic tumor",
          "CNS melanocytic tumour",
          "central nervous system melanocytic neoplasm",
          "central nervous system melanocytic neoplasms",
          "central nervous system melanocytic tumor",
          "central nervous system melanocytic tumour",
          "melanocytic neoplasm of CNS",
          "melanocytic neoplasm of central nervous system",
          "melanocytic neoplasm of the CNS",
          "melanocytic neoplasm of the central nervous system",
          "melanocytic tumor of CNS",
          "melanocytic tumor of central nervous system",
          "melanocytic tumor of the central nervous system",
          "melanocytic tumour of CNS",
          "melanocytic tumour of central nervous system",
          "melanocytic tumour of the CNS",
          "melanocytic tumour of the central nervous system"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A primary tumor of the central nervous system that arises from leptomeningeal melanocytes. It may present as a diffuse proliferative leptomeningeal process (often as a component of the neurocutaneous melanosis complex) or as a distinct mass lesion."
      },
      "child_count": 6,
      "reference_id": "MONDO:0003222"
    },
    {
      "id": 7853,
      "label": "non-cutaneous melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6832
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "EFO:1000397",
          "MEDGEN:233761",
          "NCIT:C8711",
          "UMLS:C1334974"
        ],
        "synonyms": [
          "extracutaneous melanoma",
          "non-cutaneous melanoma"
        ],
        "definition": "Melanoma is a malignant tumor of melanocytes, cells that are derived from the neural crest. Although most melanomas arise in the skin, they also may arise from mucosal surfaces or at other sites to which neural crest cells migrate. (PDQ)"
      },
      "child_count": 4,
      "reference_id": "MONDO:0006320"
    }
  ],
  "children": [
    {
      "id": 4067,
      "label": "spinal cord melanoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5449,
        17195
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:14151",
          "GARD:0023031",
          "MEDGEN:236837",
          "NCIT:C5158",
          "UMLS:C1336045"
        ],
        "synonyms": [
          "melanoma (disease) of spinal cord",
          "melanoma of spinal cord",
          "melanoma of the spinal cord",
          "spinal cord melanoma",
          "spinal cord melanoma (disease)"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A melanoma (disease) that involves the spinal cord."
      },
      "child_count": 0,
      "reference_id": "MONDO:0001893"
    },
    {
      "id": 5641,
      "label": "leptomeningeal melanoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        5642,
        17195
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6085",
          "GARD:0023656",
          "NCIT:C5317",
          "SCTID:277530005"
        ],
        "synonyms": [
          "leptomeningeal melanoma",
          "leptomeninx melanoma",
          "leptomeninx melanoma (disease)",
          "malignant melanoma of meninges",
          "melanoma (disease) of leptomeninx",
          "melanoma of the leptomeninges",
          "meningeal melanoma",
          "melanoma of leptomeninges"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A melanoma that arises from leptomeningeal melanocytes."
      },
      "child_count": 4,
      "reference_id": "MONDO:0003761"
    },
    {
      "id": 6314,
      "label": "meningeal melanomatosis",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        5968,
        17195,
        20501
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:8243",
          "GARD:0024044",
          "ICDO:8728/3",
          "MEDGEN:226843",
          "NCIT:C6891",
          "UMLS:C1266114"
        ],
        "synonyms": [
          "melanomatosis of meningeal cluster",
          "meningeal cluster melanomatosis",
          "meningeal melanomatosis",
          "meningeal melanomatosis (morphologic abnormality)",
          "leptomeningeal melanomatosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A meningeal melanoma with secondary diffuse meningeal spread. (WHO)"
      },
      "child_count": 0,
      "reference_id": "MONDO:0004512"
    }
  ],
  "roots": [
    {
      "id": 5175,
      "label": "central nervous system melanocytic neoplasm"
    },
    {
      "id": 7853,
      "label": "non-cutaneous melanoma"
    }
  ]
}