{
  "id": 17196,
  "label": "hemangioblastoma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016748",
  "properties": {
    "xrefs": [
      "DOID:5241",
      "GARD:0008232",
      "ICDO:9161/1",
      "MEDGEN:104929",
      "MESH:D018325",
      "MedDRA:10018813",
      "NCIT:C3801",
      "ONCOTREE:HMBL",
      "Orphanet:252054",
      "UMLS:C0206734"
    ],
    "synonyms": [
      "angioblastoma",
      "capillary hemangioblastoma",
      "hemangioblastoma",
      "HMBL"
    ],
    "categories": [
      {
        "ref": "MONDO:0004995",
        "name": "cardiovascular disorder"
      },
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Hemangioblastoma is a rare, benign, highly vascularized tumor of the central nervous system, most often located in the cerebellum or spinal cord, presenting in adulthood and manifesting with dizziness, nausea, malaise, headache, bladder or bowel dysfunction, numbness, weakness and pain in the upper or lower extremities, and often associated with von Hippel-Lindau disease (VHL). Exceptional cases of hemangioblastoma arising outside of the central nervous system have been reported."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 3049,
      "label": "nervous system benign neoplasm",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6887,
        20456
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0060115",
          "ICD9:225.8",
          "ICD9:225.9",
          "MEDGEN:99232",
          "NCIT:C4789",
          "SCTID:92247009",
          "UMLS:C0497550"
        ],
        "synonyms": [
          "benign neoplasm of nervous system",
          "benign neoplasm of the nervous system",
          "benign nervous system neoplasm",
          "benign nervous system tumor",
          "benign nervous system tumour",
          "benign tumor of nervous system",
          "benign tumor of the nervous system",
          "benign tumour of nervous system",
          "benign tumour of the nervous system",
          "nervous system benign neoplasm",
          "nervous system neoplasm, benign"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "Abnormal growth of cells in the nervous system without evidence of malignant characteristics. Unlike other organ systems, tumors in the central nervous system can have benign histological characteristics but still have life threatening effects due to their location within the neuraxis (e.g., brainstem gliomas)."
      },
      "child_count": 10,
      "reference_id": "MONDO:0000648"
    },
    {
      "id": 4497,
      "label": "capillary hemangioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        7994
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2725",
          "ICDO:9131/0",
          "MEDGEN:64643",
          "MESH:D018324",
          "NCIT:C7457",
          "SCTID:56975005",
          "UMLS:C0206733"
        ],
        "synonyms": [
          "capillary angioma",
          "capillary hemangioma",
          "capillary hemangioma (morphologic abnormality)",
          "cellular hemangioma of infancy",
          "cellular hemangioma of infancy (strawberry nevus)",
          "infantile hemangioma",
          "juvenile hemangioma"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          }
        ],
        "definition": "A common hemangioma characterized by the presence of capillary-sized vascular channels without prominent epithelioid endothelial cells."
      },
      "child_count": 6,
      "reference_id": "MONDO:0002407"
    },
    {
      "id": 23165,
      "label": "neurovascular disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6799,
        7065
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "MEDGEN:857738",
          "NCIT:C117007",
          "UMLS:C3898144"
        ],
        "synonyms": [
          "disease of nervous system vasculature",
          "nervous system disorder of vasculature",
          "neurovascular disorder",
          "vasculature nervous system disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A disorder of the nervous system related to a vascular etiology."
      },
      "child_count": 58,
      "reference_id": "MONDO:0043218"
    }
  ],
  "children": [
    {
      "id": 5279,
      "label": "retinal hemangioblastoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4419,
        17196,
        20657
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:5240",
          "GARD:0023461",
          "MEDGEN:152677",
          "NCIT:C39783",
          "UMLS:C0730303"
        ],
        "synonyms": [
          "hemangioblastoma of vasculature of retina",
          "retinal capillary hemangioblastoma",
          "retinal hemangioblastoma",
          "vasculature of retina hemangioblastoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0002022",
            "name": "disorder of orbital region"
          },
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0024458",
            "name": "disorder of visual system"
          }
        ],
        "definition": "A hemangioblastoma that arises from the retina. It is typically a sign of von Hippel-Lindau disease. It may also be seen as an isolated entity without systemic involvement."
      },
      "child_count": 3,
      "reference_id": "MONDO:0003343"
    },
    {
      "id": 5763,
      "label": "cerebellar hemangioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4434,
        17196,
        20620
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6500",
          "GARD:0023722",
          "MEDGEN:234108",
          "NCIT:C5146",
          "UMLS:C1332900"
        ],
        "synonyms": [
          "angioblastoma of cerebellum",
          "angioblastoma of the cerebellum",
          "cerebellar angioblastoma",
          "cerebellar capillary hemangioblastoma",
          "cerebellar hemangioblastoma",
          "cerebellum hemangioblastoma",
          "hemangioblastoma of cerebellum",
          "hemangioblastoma of the cerebellum"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A histologically benign tumor, usually cystic with a vascular mural nodule, that is most often found in the cerebellum though it has been reported at other sites within the neuraxis. It is associated with von Hippel-Lindau disease (VHL gene located on chr 3p25-26)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003901"
    },
    {
      "id": 5764,
      "label": "brain stem hemangioblastoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        4434,
        17196,
        20626
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6501",
          "GARD:0023723",
          "MEDGEN:231461",
          "NCIT:C5147",
          "UMLS:C1332611"
        ],
        "synonyms": [
          "angioblastoma of brain stem",
          "angioblastoma of brainstem",
          "angioblastoma of the brain stem",
          "angioblastoma of the brainstem",
          "brain stem angioblastoma",
          "brain stem capillary hemangioblastoma",
          "brain stem hemangioblastoma",
          "brainstem angioblastoma",
          "brainstem hemangioblastoma",
          "hemangioblastoma of brain stem",
          "hemangioblastoma of brainstem",
          "hemangioblastoma of the brain stem",
          "hemangioblastoma of the brainstem"
        ],
        "categories": [
          {
            "ref": "MONDO:0004995",
            "name": "cardiovascular disorder"
          },
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "A hemangioblastoma that involves the brainstem."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003902"
    }
  ],
  "roots": [
    {
      "id": 3049,
      "label": "nervous system benign neoplasm"
    },
    {
      "id": 4497,
      "label": "capillary hemangioma"
    },
    {
      "id": 23165,
      "label": "neurovascular disorder"
    }
  ]
}