{
  "id": 17386,
  "label": "thymoma type B",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016974",
  "properties": {
    "xrefs": [
      "DOID:3282",
      "GARD:0020893",
      "MEDGEN:231253",
      "NCIT:C7114",
      "Orphanet:263317",
      "UMLS:C1328042"
    ],
    "synonyms": [
      "Dendritic cell thymoma",
      "dendritic cell thymoma",
      "dendritic cell thymoma (disease)",
      "epithelioid thymoma",
      "plump cell thymoma",
      "primary thymic epithelial neoplasm type B",
      "primary thymic epithelial tumor type B",
      "primary thymic epithelial tumour type B",
      "thymoma type B"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "An epithelial neoplasm arising from the thymus. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It includes thymoma type B1 which is a thymoma of low grade malignant potential, thymoma type B2 which is a thymoma of moderate malignancy, and thymoma type B3 which is also known as well differentiated thymic carcinoma."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 6569,
      "label": "leukocyte disorder",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        6778,
        7217
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:9500",
          "ICD9:288",
          "ICD9:288.9",
          "MEDGEN:7325",
          "MESH:D007960",
          "SCTID:54097007",
          "UMLS:C0023510"
        ],
        "synonyms": [
          "disease of leukocyte",
          "disease or disorder of leukocyte",
          "disorder of leukocyte",
          "disorder, leukocyte",
          "disorders, leukocyte",
          "leukocyte disease",
          "leukocyte disease or disorder",
          "leukocyte disorder",
          "white blood cell disorder"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A disease involving leukocytes."
      },
      "child_count": 46,
      "reference_id": "MONDO:0004805"
    },
    {
      "id": 7959,
      "label": "thymoma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        18240
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:3275",
          "EFO:1000581",
          "GARD:0016922",
          "HP:0100522",
          "ICD9:239.89",
          "ICDO:8580/1",
          "MEDGEN:52743",
          "MESH:D013945",
          "MedDRA:10043670",
          "NCIT:C3411",
          "ONCOTREE:THYM",
          "Orphanet:99867",
          "SCTID:444231005",
          "UMLS:C0040100",
          "icd11.foundation:33869057"
        ],
        "synonyms": [
          "primary thymic epithelial neoplasm",
          "primary thymic epithelial tumor",
          "primary thymic epithelial tumour",
          "thymoma",
          "thymoma (disease)",
          "THYM"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A neoplasm arising from the epithelial cells of the thymus. Although thymomas are usually encapsulated tumors, they may invade the capsule and infiltrate the surrounding tissues or even metastasize to distant anatomic sites. The following morphologic subtypes are currently recognized: type A, type B, type AB, metaplastic, micronodular, microscopic, and sclerosing thymoma. Thymomas type B are further subdivided into types B1, B2, and B3. Thymoma type B3 usually has the most aggressive clinical course."
      },
      "child_count": 8,
      "reference_id": "MONDO:0006456"
    }
  ],
  "children": [
    {
      "id": 5776,
      "label": "cortical thymoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17386
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6530",
          "GARD:0023732",
          "ICDO:8584/1",
          "MEDGEN:224762",
          "NCIT:C6888",
          "UMLS:C1266095"
        ],
        "synonyms": [
          "cortical thymoma",
          "polygonal cell thymoma",
          "thymoma type B2"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A thymic epithelial neoplasm characterized by the presence of neoplastic large, polygonal epithelial cells with large vesicular nuclei and prominent nucleoli. The neoplastic cells are arranged around perivascular spaces and along septa. Immature T-lymphocytes are also present. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It is a tumor of moderate malignancy. The majority of cases occur in the anterior mediastinum as Masaoka stage I, stage II, or stage III tumors. Metastatic, stage IV tumors occur less frequently."
      },
      "child_count": 0,
      "reference_id": "MONDO:0003915"
    },
    {
      "id": 7960,
      "label": "thymoma type B3",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17386
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:7926",
          "EFO:1000583",
          "GARD:0024417",
          "ICDO:8585/1",
          "ICDO:8585/3",
          "MEDGEN:124648",
          "NCIT:C7997",
          "UMLS:C0279705"
        ],
        "synonyms": [
          "atypical thymoma",
          "epithelial malignant thymoma",
          "epithelial thymoma",
          "malignant thymoma type B3",
          "squamoid thymoma",
          "thymoma type B3",
          "well differentiated thymic carcinoma",
          "well-differentiated thymic carcinoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Also known as well-differentiated thymic carcinoma, atypical thymoma, or epithelial thymoma, this type of thymoma displays morphologic characteristics of a well-differentiated carcinoma. The majority of cases occur in the anterior mediastinum as Masaoka stage II or stage III tumors. It is almost always invasive, it recurs frequently, and metastasizes in approximately 20% of the cases."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006458"
    },
    {
      "id": 7961,
      "label": "thymoma type B1",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17386
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:6917",
          "EFO:1000584",
          "GARD:0024418",
          "ICDO:8583/1",
          "MEDGEN:224761",
          "NCIT:C6887",
          "UMLS:C1266094"
        ],
        "synonyms": [
          "lymphocyte-predominant thymoma",
          "lymphocyte-rich thymoma",
          "organoid thymoma",
          "predominantly cortical thymoma",
          "thymoma type B1"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A thymic epithelial neoplasm characterized by the presence of expanded areas which resemble the normal thymic cortex. The neoplastic epithelial cells are small and scant and there is a dense T-lymphocytic component present. Areas of medullary differentiation with or without Hassall's corpuscles are also present. It may be associated with myasthenia gravis, pure red cell aplasia, and hypogammaglobulinemia. It has a low grade malignant potential. The majority of cases occur in the anterior mediastinum as Masaoka stage I tumors. A minority of the cases occur as stage II tumors."
      },
      "child_count": 0,
      "reference_id": "MONDO:0006459"
    }
  ],
  "roots": [
    {
      "id": 6569,
      "label": "leukocyte disorder"
    },
    {
      "id": 7959,
      "label": "thymoma"
    }
  ]
}