{
  "id": 17403,
  "label": "acute necrotizing encephalopathy of childhood",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0016991",
  "properties": {
    "xrefs": [
      "GARD:0017257",
      "MEDGEN:1641610",
      "Orphanet:263524",
      "SCTID:763310000",
      "UMLS:C4706387"
    ],
    "synonyms": [
      "ANEC",
      "isolated ANE",
      "isolated acute necrotizing encephalopathy"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      }
    ],
    "definition": "Acute necrotizing encephalopathy of childhood is a rare neurologic disease characterized by a rapid onset of seizures, an altered state of consciousness, neurologic decline, and variable degrees of hepatic dysfunction following a respiratory or gastrointesitnal infection (e.g. mycoplasma, influenza virus) in a previously healthy child. Brain MRI of patients reveals bilateral, multiple, symmetrical lesions predominantly observed in thalami and brainstem, but also in periventricular white matter and cerebellum in some cases."
  },
  "isLeaf": true,
  "isRoot": false,
  "child_count": 0,
  "parents": [
    {
      "id": 19721,
      "label": "infectious encephalitis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        19673,
        21534
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025151",
          "ICD9:049.8",
          "ICD9:323.4",
          "MEDGEN:108917",
          "MESH:D000069544",
          "NCIT:C79550",
          "SCTID:312215006",
          "UMLS:C0596773"
        ],
        "synonyms": [
          "encephalitis infection"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          }
        ],
        "definition": "An acute infectious process that affects the brain tissue. It is usually caused by viruses and less often by bacteria, parasites, and fungi."
      },
      "child_count": 20,
      "reference_id": "MONDO:0020067"
    }
  ],
  "children": [],
  "roots": [
    {
      "id": 19721,
      "label": "infectious encephalitis"
    }
  ]
}