{
  "id": 17420,
  "label": "Langerhans cell histiocytosis specific to childhood",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017025",
  "properties": {
    "xrefs": [
      "GARD:0025085",
      "MEDGEN:859249",
      "NANDO:2200031",
      "NCIT:C114483",
      "Orphanet:264724",
      "UMLS:C3899655"
    ],
    "synonyms": [
      "Langerhans cell histiocytosis",
      "Langerhans cell granulomatosis specific to childhood",
      "childhood Langerhans cell histiocytosis",
      "histiocytosis X specific to childhood"
    ],
    "categories": [
      {
        "ref": "MONDO:0005046",
        "name": "immune system disorder"
      },
      {
        "ref": "MONDO:0005570",
        "name": "hematologic disorder"
      }
    ],
    "definition": "Langerhans cell histiocytosis that occurs during childhood."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 2,
  "parents": [
    {
      "id": 18407,
      "label": "Langerhans cell histiocytosis",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4688,
        6569,
        19729,
        21541
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:2571",
          "EFO:1000318",
          "GARD:0006858",
          "ICD9:202.5",
          "ICD9:277.89",
          "ICDO:9751/1",
          "ICDO:9751/3",
          "ICDO:9752/1",
          "ICDO:9753/1",
          "ICDO:9754/3",
          "MEDGEN:5568",
          "MedDRA:10069698",
          "NANDO:2200031",
          "NCIT:C3107",
          "NORD:1348",
          "OMIM:604856",
          "ONCOTREE:LCH",
          "Orphanet:389",
          "SCTID:65399007",
          "UMLS:C0019621",
          "icd11.foundation:1388720498",
          "icd11.foundation:216625985"
        ],
        "synonyms": [
          "LCH",
          "Langerhans cell granulomatosis",
          "Langerhans cell histiocytosis",
          "Langerhans cell histiocytosis, NOS",
          "Langerhans cell histiocytosis, Not otherwise specified",
          "histiocytosis X",
          "Langerhans-cell histiocytosis",
          "Lch"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Langerhans cell histiocytosis (LCH) is a systemic disease associated with the proliferation and accumulation (usually in granulomas) of Langerhans cells in various tissues."
      },
      "child_count": 32,
      "reference_id": "MONDO:0018310"
    }
  ],
  "children": [
    {
      "id": 10743,
      "label": "letterer-Siwe disease",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0024676",
          "ICD10CM:C96.0",
          "ICDO:9754/3",
          "MEDGEN:7311",
          "MedDRA:10024265",
          "NCIT:C3160",
          "OMIM:246400",
          "Orphanet:99870",
          "UMLS:C0023381",
          "icd11.foundation:1827474596"
        ],
        "synonyms": [
          "acute and disseminated Langerhans cell histiocytosis",
          "acute disseminated Langerhans cell histiocytosis",
          "letterer-Siwe disease",
          "multifocal multisystem Langerhans cell histiocytosis",
          "L-S disease",
          "histiocytosis X, acute disseminated"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "A multifocal, multisystem form of Langerhans-cell histiocytosis. There is involvement of multiple organ systems including the bones, skin, liver, spleen, and lymph nodes. Patients are usually infants presenting with fever, hepatosplenomegaly, lymphadenopathy, bone and skin lesions, and pancytopenia."
      },
      "child_count": 0,
      "reference_id": "MONDO:0009519"
    },
    {
      "id": 19967,
      "label": "Hashimoto-Pritzker syndrome",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17420
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0002604",
          "ICD9:277.89",
          "MEDGEN:775638",
          "MESH:C535843",
          "Orphanet:99872",
          "SCTID:404160007",
          "UMLS:C3661439",
          "icd11.foundation:1011705244"
        ],
        "synonyms": [
          "congenital Langerhans cell histiocytosis",
          "Hashimoto-Pritzker disease",
          "Hashimoto-Pritzker histiocytosis"
        ],
        "categories": [
          {
            "ref": "MONDO:0005046",
            "name": "immune system disorder"
          },
          {
            "ref": "MONDO:0005570",
            "name": "hematologic disorder"
          }
        ],
        "definition": "Hashimoto-Pritzker histiocytosis (HPH) is a variant of Langerhans cell histiocytosis characterized by multiple disseminated skin lesions (firm, red-brown, painless papulo-nodules)."
      },
      "child_count": 0,
      "reference_id": "MONDO:0020518"
    }
  ],
  "roots": [
    {
      "id": 18407,
      "label": "Langerhans cell histiocytosis"
    }
  ]
}