{
  "id": 17532,
  "label": "sporadic pheochromocytoma/secreting paraganglioma",
  "model": {
    "label": "Mondo Disease Ontology (MONDO)",
    "source": 0
  },
  "type_id": 0,
  "reference_id": "MONDO:0017190",
  "properties": {
    "xrefs": [
      "GARD:0007385",
      "MEDGEN:1636854",
      "Orphanet:276621",
      "UMLS:C4707333"
    ],
    "categories": [
      {
        "ref": "MONDO:0005071",
        "name": "nervous system disorder"
      },
      {
        "ref": "MONDO:0005151",
        "name": "endocrine system disorder"
      }
    ],
    "definition": "Sporadic pheochromocytoma/secreting paraganglioma are isolated, non-familial, catecholamin-producing tumors arising from neuroendocrine chromaffin cells in the adrenal medulla or in extra-adrenal chromaffin tissue, respectively. The majority of these tumors are benign and the presenting symptoms are typically caused by the increased catecholamine production of the tumor, including hypertension (often paroxysmal), tachycardia, anxiety and/or excessive sweating."
  },
  "isLeaf": false,
  "isRoot": false,
  "child_count": 3,
  "parents": [
    {
      "id": 2912,
      "label": "paraganglioma",
      "isLeaf": false,
      "isRoot": false,
      "parents": [
        4464,
        19314,
        20691,
        24270
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "DOID:0050773",
          "EFO:1000453",
          "GARD:0022770",
          "ICD9:239.7",
          "ICDO:8680/1",
          "MEDGEN:10571",
          "MESH:D010235",
          "NCIT:C3308",
          "ONCOTREE:PGNG",
          "SCTID:127027008",
          "UMLS:C0030421"
        ],
        "synonyms": [
          "Paraganglionic neoplasm",
          "Paraganglionic tumor",
          "Paraganglionic tumour",
          "neoplasm of paraganglion",
          "neoplasm of the paraganglion",
          "paraganglioma",
          "paragangliomas",
          "paraganglion neoplasm",
          "paraganglion tumor",
          "paraganglion tumour",
          "tumor of paraganglion",
          "tumor of the paraganglion",
          "tumour of paraganglion",
          "tumour of the paraganglion",
          "chemodectoma"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ],
        "definition": "A benign or malignant neoplasm arising from paraganglia located along the sympathetic or parasympathetic nerves. Infrequently, it may arise outside the usual distribution of the sympathetic and parasympathetic paraganglia. Tumors arising from the adrenal gland medulla are called pheochromocytomas. Morphologically, paragangliomas usually display a nesting (Zellballen) growth pattern. There are no reliable morphologic criteria to distinguish between benign and malignant paragangliomas. The only definitive indicator of malignancy is the presence of regional or distant metastases."
      },
      "child_count": 48,
      "reference_id": "MONDO:0000448"
    }
  ],
  "children": [
    {
      "id": 17533,
      "label": "sporadic pheochromocytoma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17532
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025089",
          "Orphanet:276624"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017191"
    },
    {
      "id": 17534,
      "label": "sporadic secreting paraganglioma",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17532
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0025090",
          "Orphanet:276627"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017192"
    },
    {
      "id": 18126,
      "label": "multiple paragangliomas associated with polycythemia",
      "isLeaf": true,
      "isRoot": false,
      "parents": [
        17532
      ],
      "type_id": 0,
      "properties": {
        "xrefs": [
          "GARD:0021435",
          "MEDGEN:1812993",
          "Orphanet:324299",
          "UMLS:C5679884"
        ],
        "synonyms": [
          "multiple paragangliomas associated with erythrocytosis",
          "paraganglioma-somatostatinoma-polycythemia syndrome"
        ],
        "categories": [
          {
            "ref": "MONDO:0005071",
            "name": "nervous system disorder"
          },
          {
            "ref": "MONDO:0005151",
            "name": "endocrine system disorder"
          }
        ]
      },
      "child_count": 0,
      "reference_id": "MONDO:0017926"
    }
  ],
  "roots": [
    {
      "id": 2912,
      "label": "paraganglioma"
    }
  ]
}